TAC1

Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
File:PBB Protein TAC1 image.jpg PDB rendering based on 2b19.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2b19​
Identifiers
Symbols	TAC1 ; Hs.2563; NK2; NKNA; TAC2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2394
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TAC1 206552 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma), also known as TAC1, is a human gene.

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.

Further reading

• Kowall NW, Quigley BJ, Krause JE; et al. (1993). "Substance P and substance P receptor histochemistry in human neurodegenerative diseases". Regul. Pept. 46 (1–2): 174–85. PMID 7692486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Advenier C, Lagente V, Boichot E (1997). "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough". Eur. Respir. J. 10 (8): 1892–906. PMID 9272936.CS1 maint: Multiple names: authors list (link)
• Rameshwar P, Oh HS, Yook C; et al. (2003). "Substance p-fibronectin-cytokine interactions in myeloproliferative disorders with bone marrow fibrosis". Acta Haematol. 109 (1): 1–10. PMID 12486316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito R, Takano Y, Kamiya HO (2003). "Roles of substance P and NK(1) receptor in the brainstem in the development of emesis". J. Pharmacol. Sci. 91 (2): 87–94. PMID 12686752.CS1 maint: Multiple names: authors list (link)
• Di Angelantonio S, Giniatullin R, Costa V; et al. (2004). "Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells". Br. J. Pharmacol. 139 (6): 1061–73. doi:10.1038/sj.bjp.0705337. PMID 12871824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bannon MJ, Poosch MS, Haverstick DM; et al. (1992). "Preprotachykinin gene expression in the human basal ganglia: characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing". Brain Res. Mol. Brain Res. 12 (1–3): 225–31. PMID 1312203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiwakata C, Brackmann B, Hunt N; et al. (1991). "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis". Endocrinology. 128 (5): 2441–8. PMID 1708336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McGregor GP, Conlon JM (1991). "Characterization of the C-terminal flanking peptide of human beta-preprotachykinin". Peptides. 11 (5): 907–10. PMID 2284201.
• Theodorsson-Norheim E, Jörnvall H, Andersson M; et al. (1987). "Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour". Eur. J. Biochem. 166 (3): 693–7. PMID 3038549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harmar AJ, Armstrong A, Pascall JC; et al. (1986). "cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A.". FEBS Lett. 208 (1): 67–72. PMID 3770210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. Chem. 269 (44): 27269–74. PMID 7961636.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity". J. Biol. Chem. 271 (34): 20250–7. PMID 8702757.CS1 maint: Multiple names: authors list (link)
• Tanabe T, Otani H, Zeng XT; et al. (1997). "Inhibitory effects of calcitonin gene-related peptide on substance-P-induced superoxide production in human neutrophils". Eur. J. Pharmacol. 314 (1–2): 175–83. PMID 8957234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zimmer A, Zimmer AM, Baffi J; et al. (1998). "Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2630–5. PMID 9482938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ho WZ, Lai JP, Zhu XH; et al. (1998). "Human monocytes and macrophages express substance P and neurokinin-1 receptor". J. Immunol. 159 (11): 5654–60. PMID 9548509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai JP, Douglas SD, Ho WZ (1998). "Human lymphocytes express substance P and its receptor". J. Neuroimmunol. 86 (1): 80–6. PMID 9655475.CS1 maint: Multiple names: authors list (link)