T-cell lymphoma classification: Difference between revisions

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==Overview==
==Overview==
 
* T cell lymphoma may be classified according to The 2016 WHO update on mature T- and natural killer (NK) cell neoplasms that is is cearly updating the 2008 WHO (world health organization) classification. Based on the duration of symptoms and clinical practice Non-Hodgkin's lymphoma classification may be classified 3 common lymphoma types.
There is no established system for the classification of [disease name].
 
OR
 
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
 
OR
 
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3].
[Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
 
OR
 
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
 
OR
 
If the staging system involves specific and characteristic findings and features:
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
 
OR
 
The staging of [malignancy name] is based on the [staging system].
 
OR
 
There is no established system for the staging of [malignancy name].


==Classification==
==Classification==


Based on the 2017 revision of the World Health Organization classification of lymphoid neoplasms classified there are four clinical variants of adult T cell leukemia-lymphoma (ATL).
According to the the 2017 revision of the World Health Organization classification of T‐ and natural killer (NK) cell neoplasms is:<ref name="Matutes2018">{{cite journal|last1=Matutes|first1=E.|title=The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms|journal=International Journal of Laboratory Hematology|volume=40|year=2018|pages=97–103|issn=17515521|doi=10.1111/ijlh.12817}}</ref>
* Acute
*T cell prolymphocytic leukemia
* Lymphoma-type
*T cell large granular lymphocytic leukemia
* Chronic
*Aggressive NK cell leukemia
* Smoldering
*Systemic EBV+ T cell lymphoma of childhood*
* 1—dysregulation of the JAK/STAT pathway due to gene mutations which are common to various aggressive and indolent neoplasms
*Hydroa vacciniforme-like lymphoproliferative disorder*
'''If the staging system involves specific and characteristic findings and features:'''
*Adult T cell leukemia/lymphoma
 
*Extranodal NK/T cell lymphoma, nasal type
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
*Enteropathy-associated T cell lymphoma
 
*Monomorphic epitheliotropic intestinal T cell lymphoma*
OR
*Hepatosplenic T cell lymphoma
 
*Subcutaneous panniculitis-like T cell lymphoma
The staging of [malignancy name] is based on the [staging system].
*Mycosis fungoides
 
*Sézary syndrome
OR
*Primary cutaneous CD30+ T cell lymphoproliferative disorders
 
* Lymphomatoid papulosis
There is no established system for the staging of [malignancy name].
 
 
===Updated World Health Organization Classification <ref>{{cite book | last = Swerdlow | first = Steven | title = WHO classification of tumours of haematopoietic and lymphoid tissues | publisher = International Agency for Research on Cancer | location = Lyon, France | year = 2008 | isbn = 9789283224310 }}</ref>===


*T-cell and putative NK-cell neoplasms
* Primary cutaneous anaplastic large cell lymphoma
**Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL
*Primary cutaneous γδ T cell lymphoma
**[[Peripheral T-cell lymphomas]] and [[NK-cell lymphomas]]
*Peripheral T cell lymphoma, NOS
*Angioimmunoblastic T cell lymphoma
*Anaplastic large cell lymphoma, ALK+
*Anaplastic large cell lymphoma, ALK–
Based on the duration of symptoms and clinical practice of Non-Hodgkin's lymphoma may be classified 3 common lymphoma types  for T- and natural killer (NK) cell lymphomas:<ref name="ArmitageWeisenburger1998">{{cite journal|last1=Armitage|first1=J O|last2=Weisenburger|first2=D D|title=New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project.|journal=Journal of Clinical Oncology|volume=16|issue=8|year=1998|pages=2780–2795|issn=0732-183X|doi=10.1200/JCO.1998.16.8.2780}}</ref>


===Peripheral T Cell Lymphoma===
*'''The indolent lymphomas''':
The WHO classification of T-cells [[NHL]] categorize them into Precursor T-cell neoplasm and Peripheral T-cell lymphomas/NK-cell neoplasms. The last one can be further subdivided into:  
**T-cell large granular lymphocyte leukemia
*T-cell [[prolymphocytic leukemia]]
**Mycosis fungoides
*[[T-cell large granular lymphocytic leukemia]]
**T-cell prolymphocytic leukemia
*[[Chronic lymphoproliferative disorder of NK cells]]
**Natural killer cell large granular lymphocyte leukemia
*[[Aggressive NK-cell leukemia]]
*'''The aggressive lymphomas''':
*EBV positive T-cell lymphoproliferative disorders of childhood
** Peripheral T-cell lymphoma
**[[Systemic EBV positive T-cell lymphoproliferative disease of childhood]]
**Anaplastic large cell lymphoma, T/null cell
**[[Hydroa vacciniforme-like lymphoma]]
*'''The highly aggressive lymphomas''':
*[[Adult T-cell lymphoma/leukemia]]
** Adult T-cell lymphoma/leukemia
*[[Extranodal T-/NK-cell lymphoma, nasal type]]
**Precursor T lymphoblastic leukemia/lymphoma
*[[Enteropathy-associated T-cell lymphoma]]
*[[Hepatosplenic T-cell lymphoma]]
*[[Subcutaneous panniculitis-like T-cell lymphoma]]
*[[Mycosis fungoides]]
*[[Sézary syndrome]]
*[[Primary cutaneous CD30 positive T-cell lymphoproliferative disorders]]
**[[Primary cutaneous anaplastic large cell lymphoma]]
**[[Lymphomatoid papulosis]]
*Primary cutaneous peripheral T-cell lymphomas, rare subtypes
**[[Primary cutaneous gamma-delta T-cell lymphoma]]
**[[Primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma]]
**[[Primary cutaneous CD4 positive small/medium T-cell lymphoma]]
*[[Peripheral T-cell lymphoma, not otherwise characterized]]
*[[Angioimmunoblastic T-cell lymphoma]]
*[[Anaplastic large cell lymphoma, ALK positive]]
*[[Anaplastic large cell lymphoma, ALK negative]]


==References==
==References==

Latest revision as of 16:53, 30 October 2018

T-cell lymphoma Microchapters

Home

Patient Information

Overview

Classification

Lymphoblastic lymphoma
T-cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK-cell leukemia
Adult T-cell leukemia/lymphoma
Enteropathy-type intestinal T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

  • T cell lymphoma may be classified according to The 2016 WHO update on mature T- and natural killer (NK) cell neoplasms that is is cearly updating the 2008 WHO (world health organization) classification. Based on the duration of symptoms and clinical practice Non-Hodgkin's lymphoma classification may be classified 3 common lymphoma types.

Classification

According to the the 2017 revision of the World Health Organization classification of T‐ and natural killer (NK) cell neoplasms is:[1]

  • T cell prolymphocytic leukemia
  • T cell large granular lymphocytic leukemia
  • Aggressive NK cell leukemia
  • Systemic EBV+ T cell lymphoma of childhood*
  • Hydroa vacciniforme-like lymphoproliferative disorder*
  • Adult T cell leukemia/lymphoma
  • Extranodal NK/T cell lymphoma, nasal type
  • Enteropathy-associated T cell lymphoma
  • Monomorphic epitheliotropic intestinal T cell lymphoma*
  • Hepatosplenic T cell lymphoma
  • Subcutaneous panniculitis-like T cell lymphoma
  • Mycosis fungoides
  • Sézary syndrome
  • Primary cutaneous CD30+ T cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
  • Primary cutaneous γδ T cell lymphoma
  • Peripheral T cell lymphoma, NOS
  • Angioimmunoblastic T cell lymphoma
  • Anaplastic large cell lymphoma, ALK+
  • Anaplastic large cell lymphoma, ALK–

Based on the duration of symptoms and clinical practice of Non-Hodgkin's lymphoma may be classified 3 common lymphoma types for T- and natural killer (NK) cell lymphomas:[2]

  • The indolent lymphomas:
    • T-cell large granular lymphocyte leukemia
    • Mycosis fungoides
    • T-cell prolymphocytic leukemia
    • Natural killer cell large granular lymphocyte leukemia
  • The aggressive lymphomas:
    • Peripheral T-cell lymphoma
    • Anaplastic large cell lymphoma, T/null cell
  • The highly aggressive lymphomas:
    • Adult T-cell lymphoma/leukemia
    • Precursor T lymphoblastic leukemia/lymphoma

References

  1. ↑ Matutes, E. (2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of Laboratory Hematology. 40: 97–103. doi:10.1111/ijlh.12817. ISSN 1751-5521.
  2. ↑ Armitage, J O; Weisenburger, D D (1998). "New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project". Journal of Clinical Oncology. 16 (8): 2780–2795. doi:10.1200/JCO.1998.16.8.2780. ISSN 0732-183X.
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