T-cell leukemia natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History== | ==Natural History== | ||
* The natural history of adult T-cell leukemia varies between the different subtypes of the disease. | * The natural history of adult T-cell leukemia varies between the different subtypes of the disease.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref> | ||
* Usually patients with '''acute''' adult T-cell leukemia have an aggressive clinical course with a median survival period of less than 12 months. If left untreated, most of the patients with acute adult T-cell leukemia will develop systemic symptoms, lymphadenopathy, and organomegaly within a few weeks of diagnosis. | * Usually patients with '''acute''' adult T-cell leukemia have an aggressive clinical course with a median survival period of less than 12 months. If left untreated, most of the patients with acute adult T-cell leukemia will develop systemic symptoms, lymphadenopathy, and organomegaly within a few weeks of diagnosis. | ||
* Usually patients with '''chronic''' adult T-cell leukemia will have an stable clinical course. If left untreated, most of the patients with chronic adult T-cell leukemia will develop lymphocytosis for months, or even years, before presenting with the typical skin manifestations. | * Usually patients with '''chronic''' adult T-cell leukemia will have an stable clinical course. If left untreated, most of the patients with chronic adult T-cell leukemia will develop lymphocytosis for months, or even years, before presenting with the typical skin manifestations. | ||
* Most patients with '''smouldering''' adult T cell leukemia are initially asymptomatic. If left untreated, most of the patients with | * Most patients with '''smouldering''' adult T cell leukemia are initially asymptomatic. If left untreated, most of the patients with smouldering adult T cell leukemia will develop steroid-responsive skin rash and multiple lung infiltrates. | ||
==Complications== | ==Complications== | ||
* Common complications of adult T-cell leukemia include: | * Common complications of adult T-cell leukemia include: | ||
Revision as of 19:26, 24 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Natural History
- The natural history of adult T-cell leukemia varies between the different subtypes of the disease.[1]
- Usually patients with acute adult T-cell leukemia have an aggressive clinical course with a median survival period of less than 12 months. If left untreated, most of the patients with acute adult T-cell leukemia will develop systemic symptoms, lymphadenopathy, and organomegaly within a few weeks of diagnosis.
- Usually patients with chronic adult T-cell leukemia will have an stable clinical course. If left untreated, most of the patients with chronic adult T-cell leukemia will develop lymphocytosis for months, or even years, before presenting with the typical skin manifestations.
- Most patients with smouldering adult T cell leukemia are initially asymptomatic. If left untreated, most of the patients with smouldering adult T cell leukemia will develop steroid-responsive skin rash and multiple lung infiltrates.
Complications
- Common complications of adult T-cell leukemia include:
- Cardiac arrhythmias (due to hypercalcaemia)
- Opportunistic infections (due to defective immune system)
- Bone fractures (due to lytic bone lesions)
Prognosis
References
- ↑ Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.