T-cell leukemia natural history, complications and prognosis: Difference between revisions
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{{Adult T-cell leukemia}} | {{Adult T-cell leukemia}} | ||
{{CMG}} {{AE}} {{HL}} | {{CMG}} {{AE}} {{HL}} | ||
==Overview== | ==Overview== | ||
==Natural History== | ==Natural History== | ||
* The natural history of adult T-cell leukemia varies between the different subtypes of the disease. | * The natural history of adult T-cell leukemia varies between the different subtypes of the disease. | ||
* Usually patients with '''acute''' adult T-cell leukemia have an aggressive clinical course with a median survival period of less than 12 months. If left untreated, most of the patients with acute adult T-cell leukemia will develop systemic symptoms, lymphadenopathy, and organomegaly within a few weeks of diagnosis. | |||
* Usually patients with '''chronic''' adult T-cell leukemia will have an stable clinical course. If left untreated, most of the patients with chronic adult T-cell leukemia will develop lymphocytosis for months, or even years, before presenting with the typical skin manifestations. | |||
* Most patients with '''smouldering''' adult T cell leukemia are initially asymptomatic. If left untreated, most of the patients with '''smouldering''' adult T cell leukemia will develop steroid-responsive skin rash and multiple lung infiltrates. | |||
==Complications== | ==Complications== | ||
* Common complications of adult T-cell leukemia include: | |||
:* Cardiac arrhythmias (due to hypercalcaemia) | |||
:* Opportunistic infections (due to defective immune system) | |||
:* Bone fractures (due to lytic bone lesions) | |||
==Prognosis== | ==Prognosis== | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:24, 24 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Natural History
- The natural history of adult T-cell leukemia varies between the different subtypes of the disease.
- Usually patients with acute adult T-cell leukemia have an aggressive clinical course with a median survival period of less than 12 months. If left untreated, most of the patients with acute adult T-cell leukemia will develop systemic symptoms, lymphadenopathy, and organomegaly within a few weeks of diagnosis.
- Usually patients with chronic adult T-cell leukemia will have an stable clinical course. If left untreated, most of the patients with chronic adult T-cell leukemia will develop lymphocytosis for months, or even years, before presenting with the typical skin manifestations.
- Most patients with smouldering adult T cell leukemia are initially asymptomatic. If left untreated, most of the patients with smouldering adult T cell leukemia will develop steroid-responsive skin rash and multiple lung infiltrates.
Complications
- Common complications of adult T-cell leukemia include:
- Cardiac arrhythmias (due to hypercalcaemia)
- Opportunistic infections (due to defective immune system)
- Bone fractures (due to lytic bone lesions)