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A sympatholytic is a medication which inhibits the functioning of the sympathetic nervous system (SNS). They are used as antihypertensives.

They mainly comprise antiadrenergic agents, but also anticholinergics in the case of the nicotinic antagonist, since nicotinic receptors relay the signals of the SNS across the ganglia.


Antiadrenergic agents inhibit the signals of adrenaline and noradrenaline. They are mainly adrenergic antagonists, inhibiting adrenergic receptors, but there are exceptions: clonidine is an adrenergic agonist on the α2 receptor, since this receptor is located presynaptically to inhibit further release of adrenaline and noradrenaline.

Other ways of inhibiting adrenergic signaling is by catecholamine synthesis blocking, e.g. by methyltyrosine. Reserpine works by inhibiting transport into synaptic vesicles of noradrenaline by inhibiting the VMAT transporter.

In hypotension

Many antiadrenergic agents used as antihypertensives include:

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| group5 = Clinical Trials Involving Sympatholytic | list5 = Ongoing Trials on Sympatholytic at Clinical Trials.govTrial results on SympatholyticClinical Trials on Sympatholytic at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Sympatholytic | list6 = US National Guidelines Clearinghouse on SympatholyticNICE Guidance on SympatholyticNHS PRODIGY GuidanceFDA on SympatholyticCDC on Sympatholytic

| group7 = Textbook Information on Sympatholytic | list7 = Books and Textbook Information on Sympatholytic

| group8 = Pharmacology Resources on Sympatholytic | list8 = AND (Dose)}} Dosing of SympatholyticAND (drug interactions)}} Drug interactions with SympatholyticAND (side effects)}} Side effects of SympatholyticAND (Allergy)}} Allergic reactions to SympatholyticAND (overdose)}} Overdose information on SympatholyticAND (carcinogenicity)}} Carcinogenicity information on SympatholyticAND (pregnancy)}} Sympatholytic in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Sympatholytic

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Sympatholytic | list9 = AND (pharmacogenomics)}} Genetics of SympatholyticAND (pharmacogenomics)}} Pharmacogenomics of SympatholyticAND (proteomics)}} Proteomics of Sympatholytic

| group10 = Newstories on Sympatholytic | list10 = Sympatholytic in the newsBe alerted to news on SympatholyticNews trends on Sympatholytic

| group11 = Commentary on Sympatholytic | list11 = Blogs on Sympatholytic

| group12 = Patient Resources on Sympatholytic | list12 = Patient resources on SympatholyticDiscussion groups on SympatholyticPatient Handouts on SympatholyticDirections to Hospitals Treating SympatholyticRisk calculators and risk factors for Sympatholytic

| group13 = Healthcare Provider Resources on Sympatholytic | list13 = Symptoms of SympatholyticCauses & Risk Factors for SympatholyticDiagnostic studies for SympatholyticTreatment of Sympatholytic

| group14 = Continuing Medical Education (CME) Programs on Sympatholytic | list14 = CME Programs on Sympatholytic

| group15 = International Resources on Sympatholytic | list15 = Sympatholytic en EspanolSympatholytic en Francais

| group16 = Business Resources on Sympatholytic | list16 = Sympatholytic in the MarketplacePatents on Sympatholytic

| group17 = Informatics Resources on Sympatholytic | list17 = List of terms related to Sympatholytic