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{{Drugbox|
{{DrugProjectFormSinglePage
|IUPAC_name = 2-[6-fluoro-2-methyl-3- [(4-methylsulfinylphenyl)methylidene]inden-1-yl]- acetic acid
|authorTag=
| image= Sulindac structure.svg
 
| CAS_number= 38194-50-2
{{VP}}
| ATC_prefix= M01
 
| ATC_suffix= AB02
<!--Overview-->
| PubChem= 5352
 
| DrugBank= APRD01243
|genericName=
| C = 20 | H = 17 | F = 1 | O = 3 | S = 1
 
| molecular_weight = 356.412 g/mol
 
| bioavailability= Approximately 90% (Oral)
 
| metabolism = ?
|aOrAn=
| elimination_half-life= 7.8 hours, metabolites up to 16.4 hours
 
| excretion = [[Kidney|Renal]] (50%) and fecal (25%)
a
| pregnancy_AU = C
 
| pregnancy_US = C
|drugClass=
| legal_UK = POM
 
| legal_US = Rx-only
 
| routes_of_administration= Oral
 
}}
|indication=
'''Sulindac''' is a [[non-steroidal anti-inflammatory drug]] of the arylalkanoic acid class that is marketed in the U.S. by [[Merck & Co.|Merck]] as '''Clinoril'''. Like other NSAIDs, it is useful in the treatment of [[Acute (medical)|acute]] or [[Chronic (medicine)|chronic]] [[inflammatory]] conditions. Sulindac is a [[prodrug]], derived from sulfinylindene that is converted in the body to an active NSAID. More specifically, the agent is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAID's except for drugs of the [[COX-2 inhibitor]] class {{Fact|date=February 2007}}. The exact mechanism of its NSAID properties is unknown, but it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.
 
 
 
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Its usual [[Effective dose|dosage]] is 150-200 [[milligram]]s twice per day, with food. It should not be used by persons with major allergic reactions ([[urticaria]] or [[anaphylaxis]]) to [[aspirin]] or other NSAIDs, and should be used with caution by persons having pre-existing [[peptic ulcer]] disease. Sulindac is much more likely than other NSAIDs to cause damage to the liver or pancreas.
|lookAlike=


Sulindac seems to have a property, independent of COX-inhibition, in reducing the growth of polyps and precancerous lesions in the colon, especially in association with [[familial adenomatous polyposis]].
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>


Sulindac is an effective [[tocolytic]] and may be used in the treatment of [[preterm labour]].  According to the Cautions distributed with this prescription drug from Walgreens, this medicine has been shown to cause harm to the human fetus.
<!--Drug Shortage Status-->


In common with other NSAIDs, sulindac is currently being investigated for its role in the treatment of [[Alzheimer's disease]].
|drugShortage=
}}


Since it was found, that the sulfoxide functional group can be reduced by methionine sulfoxide reductase A (MsrA), a possible anti-oxidative capability is being discussed.
<!--Pill Image-->


==External links==
{{PillImage
*[http://www.rxlist.com/cgi/generic3/sulindac.htm RxList information on Sulindac]
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
*[http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cli1087.shtml Drug Profile]
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<!--Label Display Image-->


{{LabelImage
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
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{{NSAIDs}}
{{LabelImage
{{Anti-inflammatory and antirheumatic products}}
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
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[[ru:Сулиндак]]
<!--Category-->


[[Category:Non-steroidal anti-inflammatory drugs]]
[[Category:Drug]]
[[Category:Prodrugs]]
[[Category:Drugs]]

Revision as of 15:03, 26 November 2014

Sulindac
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vignesh Ponnusamy, M.B.B.S. [2]

Disclaimer

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Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Sulindac is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Sulindac in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Sulindac in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Sulindac in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Sulindac in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Sulindac in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Sulindac in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Sulindac in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Sulindac in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Sulindac during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Sulindac with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Sulindac with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Sulindac with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Sulindac with respect to specific gender populations.

Race

There is no FDA guidance on the use of Sulindac with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Sulindac in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Sulindac in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Sulindac in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Sulindac in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Sulindac in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Sulindac in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Sulindac in the drug label.

Pharmacology

There is limited information regarding Sulindac Pharmacology in the drug label.

Mechanism of Action

Structure

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Sulindac in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Sulindac in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Sulindac in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Sulindac in the drug label.

How Supplied

Storage

There is limited information regarding Sulindac Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Sulindac |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Sulindac |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Sulindac in the drug label.

Precautions with Alcohol

  • Alcohol-Sulindac interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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