|
|
| (6 intermediate revisions by one other user not shown) |
| Line 1: |
Line 1: |
| __NOTOC__
| |
| {{Suicidal ideation}}
| |
|
| |
|
| {{CMG}}; {{AE}} {{Vbe}}
| |
| ==Overview==
| |
|
| |
|
| |
|
| |
| It is thought that [[suicidal]] ideation is caused by decreased expression of [[serotonin]] transporter [[gene]], studies have shown that there is decreased expression of 5 HTT(SLC6A4 gene) in [[Prefrontal cortex|prefronta]]<nowiki/>l and [[Cortical T ALL|cortical]] region. [[MAO-A|MAO]] and [[MAOB]] have also been implicated.
| |
|
| |
| ==Pathophysiology==
| |
|
| |
| Decreased [[cerebrospinal fluid]] (CSF) [[serotonin]] levels and [[serotonin]] receptor dysfunction are strong risk factors for [[suicide attempt]] and completion. Dysfunction in central [[serotonin]] systems is associated with a lowered threshold for self-directed and externally directed aggressive behavior. In 1976, As berg et al reported a bi-modal distribution of serotonin metabolites (5-HIAA) in the CSF of [[Depressed mood|depressed]] patients.In this study, significantly more of the [[Depressed mood|depressed]] patients in the "low" CSF 5-HIAA group had attempted [[suicide]] compared to the "high" CSF group. A five-year follow-up study of [[Depressed Mood|depressed]] patients concluded that patients who attempted [[suicide]] before the index admission and who reattempted suicide during the follow-up had significantly lower CSF levels of [[5-HIAA]].To date, more than 20 studies have reported low concentrations of CSF 5-HIAA in suicide attempters with a broad range of diagnoses, making this one of the strongest findings in biological [[psychiatry]]. The absolute reduction in the concentration of CSF 5-HIAA appears to correlate well with lethality, increased planning, and medical damage of the suicide attempt.The [[pharmacotherapy]] of suicidal patients often aims at increasing [[serotonin]] availability in the [[brain stem]].
| |
|
| |
| ==Genetics==
| |
| *[Disease name] is transmitted in [mode of genetic transmission] pattern.
| |
| *Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
| |
| *The development of [disease name] is the result of multiple genetic mutations.
| |
| ==Associated Conditions==
| |
|
| |
| The following conditions are associated with increased risk of [[suicidal]] ideation:
| |
|
| |
| **[[Major depressive disorder|Major depressive disorde]]<nowiki/>r
| |
| **[[Bipolar disorder]]
| |
| **[[Schizophrenia]]
| |
| **[[Post traumatic stress disorder]]
| |
| **[[Anxiety]]
| |
| **[[Personality disorders]]
| |
|
| |
| ==References==
| |
| {{Reflist|2}}
| |
|
| |
| {{WH}}
| |
| {{WS}}
| |