Stomach cancer endoscopy and biopsy: Difference between revisions

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==Overview==
==Overview==
[[Biopsy]] may be helpful in the diagnosis of stomach cancer. It has a [[Sensitivity (tests)|sensitivity]] of 98% to diagnose gastric cancer but may be negative in [[linitis plastica]]. It is commonly used nowadays as first line of treatment for superficial lesions.  
[[Biopsy]] may be helpful in the [[diagnosis]] of [[stomach cancer]]. It has a [[Sensitivity (tests)|sensitivity]] of 98% to [[diagnose]] [[gastric cancer]] but may be negative in [[linitis plastica]]. It is commonly used nowadays as first line of treatment for [[superficial]] [[lesions]].  


==Endoscopy and Biopsy==
==Endoscopy and Biopsy==
* The diagnosis of early lesions appears to be increasing since [[Upper endoscopy|upper gastrointestinal endoscopy]] became widely used.
* The [[diagnosis]] of early [[lesions]] appears to be increasing since [[Upper endoscopy|upper gastrointestinal endoscopy]] became widely used.
* Obtaining seven biopsies from the ulcer margin and base have a [[Sensitivity (tests)|sensitivity]] of 98% to diagnose gastric cancer.<ref name="pmid7054024">{{cite journal| author=Graham DY, Schwartz JT, Cain GD, Gyorkey F| title=Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma. | journal=Gastroenterology | year= 1982 | volume= 82 | issue= 2 | pages= 228-31 | pmid=7054024 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7054024  }}</ref>
* Obtaining seven [[biopsies]] from the [[ulcer]] margin and base have a [[Sensitivity (tests)|sensitivity]] of 98% to [[diagnose]] [[gastric cancer]].<ref name="pmid7054024">{{cite journal| author=Graham DY, Schwartz JT, Cain GD, Gyorkey F| title=Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma. | journal=Gastroenterology | year= 1982 | volume= 82 | issue= 2 | pages= 228-31 | pmid=7054024 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7054024  }}</ref>


* It may be falsely negative in [[Linitis plastica|linitis plastica cancers]].<ref name="pmid7859977">{{cite journal| author=Karita M, Tada M| title=Endoscopic and histologic diagnosis of submucosal tumors of the gastrointestinal tract using combined strip biopsy and bite biopsy. | journal=Gastrointest Endosc | year= 1994 | volume= 40 | issue= 6 | pages= 749-53 | pmid=7859977 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7859977  }}</ref>  
* It may be [[false negative]] in [[Linitis plastica|linitis plastica cancers]].<ref name="pmid7859977">{{cite journal| author=Karita M, Tada M| title=Endoscopic and histologic diagnosis of submucosal tumors of the gastrointestinal tract using combined strip biopsy and bite biopsy. | journal=Gastrointest Endosc | year= 1994 | volume= 40 | issue= 6 | pages= 749-53 | pmid=7859977 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7859977  }}</ref>  
* Nowadays, guidelines consider endoscopic resection as a first-line treatment for gastric superficial lesions.<ref name="pmid26317585">{{cite journal| author=Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, Repici A, Vieth M, De Ceglie A et al.| title=Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. | journal=Endoscopy | year= 2015 | volume= 47 | issue= 9 | pages= 829-54 | pmid=26317585 | doi=10.1055/s-0034-1392882 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26317585  }}</ref>  
* The European guidelines recommend [[endoscopic]] [[resection]] as a [[first-line treatment]] for [[superficial]] [[neoplastic]] [[gastric]] [[lesions]].<ref name="pmid26317585">{{cite journal| author=Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, Repici A, Vieth M, De Ceglie A et al.| title=Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. | journal=Endoscopy | year= 2015 | volume= 47 | issue= 9 | pages= 829-54 | pmid=26317585 | doi=10.1055/s-0034-1392882 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26317585  }}</ref>  
 
[[Image:Linitis plastica 2.jpg|thumb|center|200px|Endoscopic image of [[linitis plastica]], a type of stomach cancer where the entire [[stomach]] is invaded, leading to a leather bottle-like appearance.]]
[[File:Por-sig.jpg|300px|center|thumb|Endoscopy shows gastric cancer, source: By Med Chaos - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=15690680]]
[[File:Por-sig.jpg|300px|center|thumb|Endoscopy shows gastric cancer, source: By Med Chaos - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=15690680]]


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[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Surgery]]

Latest revision as of 17:13, 23 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Biopsy may be helpful in the diagnosis of stomach cancer. It has a sensitivity of 98% to diagnose gastric cancer but may be negative in linitis plastica. It is commonly used nowadays as first line of treatment for superficial lesions.

Endoscopy and Biopsy

Endoscopy shows gastric cancer, source: By Med Chaos - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=15690680

References

  1. Graham DY, Schwartz JT, Cain GD, Gyorkey F (1982). "Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma". Gastroenterology. 82 (2): 228–31. PMID 7054024.
  2. Karita M, Tada M (1994). "Endoscopic and histologic diagnosis of submucosal tumors of the gastrointestinal tract using combined strip biopsy and bite biopsy". Gastrointest Endosc. 40 (6): 749–53. PMID 7859977.
  3. Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, Repici A, Vieth M, De Ceglie A; et al. (2015). "Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline". Endoscopy. 47 (9): 829–54. doi:10.1055/s-0034-1392882. PMID 26317585.

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