Stevens-Johnson syndrome laboratory findings: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 2: Line 2:
{{Stevens-Johnson syndrome}}
{{Stevens-Johnson syndrome}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{AHS}}


==Overview==
==Overview==
SJS is mainly diagnosed through the clinical skin findings. However skin biospy is helpful in making the definitive diagnosis. Other tests are done to either rule out the superimposed bacterial infection, measure disease severity or detect the causative agent or organism. Tests include CBC, BMP, Blood cultures, ESR, CRP, IL-6, ELISA for virus detection among others.
SJS is mainly diagnosed through the clinical skin findings. However, a skin biopsy is helpful in making the definitive diagnosis. Other tests are done to either rule out the superimposed bacterial infection, measure disease severity or detect the causative agent or organism. Tests include CBC, BMP, Blood cultures, ESR, CRP, IL-6, ELISA for virus detection among others.


==Laboratory Findings==
==Laboratory Findings==
Line 11: Line 11:
Skin Biopsy is the only study that can make the definitive diagnosis of SJS. Other Lab tests are done to detect superimposed bacterial infection or in cases of severe or extensive skin involvement that is more commonly seen in TEN as compared to SJS.
Skin Biopsy is the only study that can make the definitive diagnosis of SJS. Other Lab tests are done to detect superimposed bacterial infection or in cases of severe or extensive skin involvement that is more commonly seen in TEN as compared to SJS.


First Step after suspicion of SJS is identifying and discontinuing the offending agent.
The first Step after suspicion of SJS is identifying and discontinuing the offending agent.


Following tests are done<ref name="pmid20118388">{{cite journal| author=Wetter DA, Camilleri MJ| title=Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic. | journal=Mayo Clin Proc | year= 2010 | volume= 85 | issue= 2 | pages= 131-8 | pmid=20118388 | doi=10.4065/mcp.2009.0379 | pmc=2813820 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20118388  }}</ref>:
Following tests are done<ref name="pmid20118388">{{cite journal| author=Wetter DA, Camilleri MJ| title=Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic. | journal=Mayo Clin Proc | year= 2010 | volume= 85 | issue= 2 | pages= 131-8 | pmid=20118388 | doi=10.4065/mcp.2009.0379 | pmc=2813820 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20118388 }}</ref><ref name="pmid27738400">{{cite journal| author=Çekiç Ş, Canıtez Y, Sapan N| title=Evaluation of the patients diagnosed with Stevens Johnson syndrome and toxic epidermal necrolysis: a single center experience. | journal=Turk Pediatri Ars | year= 2016 | volume= 51 | issue= 3 | pages= 152-158 | pmid=27738400 | doi=10.5152/TurkPediatriArs.2016.3836 | pmc=5047364 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27738400 }}</ref>:
* Skin Biopsy: Lesional Biopsy and Perilesional Biopsy-To confirm the diagnosis of SJS and rule out other autoimmune skin conditions ( for example Pemphigus Vulgaris, Bullous pemphigoid, GVHD, SSSS, Linear IgA bullous dermatosis)
* Skin Biopsy: Lesional Biopsy and Perilesional Biopsy-To confirm the diagnosis of SJS and rule out other autoimmune skin conditions ( for example Pemphigus Vulgaris, Bullous pemphigoid, GVHD, SSSS, Linear IgA bullous dermatosis)
* Complete Blood Count: Abnormal blood counts can be seen in case of superimposed bacterial infections
* Complete Blood Count: Abnormal blood counts can be seen in case of superimposed bacterial infections
* Metabolic Panel: Electrolyte disturbances, Glucose, BUN, Cr, Total protein, ALT, AST- Abnormalities seen in cases of extensive disease with Dehydration, Bacteremia, Hypovolumic shock and Multiorgan failure<ref name="pmid27738400">{{cite journal| author=Çekiç Ş, Canıtez Y, Sapan N| title=Evaluation of the patients diagnosed with Stevens Johnson syndrome and toxic epidermal necrolysis: a single center experience. | journal=Turk Pediatri Ars | year= 2016 | volume= 51 | issue= 3 | pages= 152-158 | pmid=27738400 | doi=10.5152/TurkPediatriArs.2016.3836 | pmc=5047364 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27738400  }}</ref>
* Metabolic Panel: Electrolyte disturbances, Glucose, BUN, Cr, Total protein, ALT, AST- Abnormalities seen in cases of extensive disease with Dehydration, Bacteremia, Hypovolemic shock and Multiorgan failure
* Bacterial and Fungal Cultures- Taken from Blood, Mucosal surfaces
* Bacterial and Fungal Cultures- Taken from Blood, Mucosal surfaces
* CRP, ESR, TNF-alpha, IL-6: Levels are typically elevated
* CRP, ESR, TNF-alpha, IL-6: Levels are typically elevated

Revision as of 15:29, 29 August 2018

Stevens-Johnson syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Stevens-Johnson Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Stevens-Johnson syndrome laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Stevens-Johnson syndrome laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Stevens-Johnson syndrome laboratory findings

CDC on Stevens-Johnson syndrome laboratory findings

Stevens-Johnson syndrome laboratory findings in the news

Blogs on Stevens-Johnson syndrome laboratory findings

Directions to Hospitals Treating Stevens-Johnson syndrome

Risk calculators and risk factors for Stevens-Johnson syndrome laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anila Hussain, MD [2]

Overview

SJS is mainly diagnosed through the clinical skin findings. However, a skin biopsy is helpful in making the definitive diagnosis. Other tests are done to either rule out the superimposed bacterial infection, measure disease severity or detect the causative agent or organism. Tests include CBC, BMP, Blood cultures, ESR, CRP, IL-6, ELISA for virus detection among others.

Laboratory Findings

Skin Biopsy is the only study that can make the definitive diagnosis of SJS. Other Lab tests are done to detect superimposed bacterial infection or in cases of severe or extensive skin involvement that is more commonly seen in TEN as compared to SJS.

The first Step after suspicion of SJS is identifying and discontinuing the offending agent.

Following tests are done[1][2]:

  • Skin Biopsy: Lesional Biopsy and Perilesional Biopsy-To confirm the diagnosis of SJS and rule out other autoimmune skin conditions ( for example Pemphigus Vulgaris, Bullous pemphigoid, GVHD, SSSS, Linear IgA bullous dermatosis)
  • Complete Blood Count: Abnormal blood counts can be seen in case of superimposed bacterial infections
  • Metabolic Panel: Electrolyte disturbances, Glucose, BUN, Cr, Total protein, ALT, AST- Abnormalities seen in cases of extensive disease with Dehydration, Bacteremia, Hypovolemic shock and Multiorgan failure
  • Bacterial and Fungal Cultures- Taken from Blood, Mucosal surfaces
  • CRP, ESR, TNF-alpha, IL-6: Levels are typically elevated
  • Bronchoscopy, EGD: may be needed to detect mucosal lesions
  • HSV-IgM
  • Mycoplasma IgM
  • ELISA-to detect other causative viruses (HAV, HBV, HCV, HIV, EBV, Rubella,

References

  1. Wetter DA, Camilleri MJ (2010). "Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic". Mayo Clin Proc. 85 (2): 131–8. doi:10.4065/mcp.2009.0379. PMC 2813820. PMID 20118388.
  2. Çekiç Ş, Canıtez Y, Sapan N (2016). "Evaluation of the patients diagnosed with Stevens Johnson syndrome and toxic epidermal necrolysis: a single center experience". Turk Pediatri Ars. 51 (3): 152–158. doi:10.5152/TurkPediatriArs.2016.3836. PMC 5047364. PMID 27738400.

Template:WH Template:WS