Squamous cell carcinoma of the skin pathophysiology

Squamous cell carcinoma of the skin Microchapters
Home
Patient Info
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Squamous cell carcinoma of the skin from other Diseases
Epidemiology & Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT Scan
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Squamous cell carcinoma of the skin pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Squamous cell carcinoma of the skin pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Squamous cell carcinoma of the skin pathophysiology
CDC on Squamous cell carcinoma of the skin pathophysiology
Squamous cell carcinoma of the skin pathophysiology in the news
Blogs on Squamous cell carcinoma of the skin pathophysiology
Directions to Hospitals Treating Squamous cell carcinoma of the skin
Risk calculators and risk factors for Squamous cell carcinoma of the skin pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

Squamous cell carcinoma (SCC) is type of non-melanoma skin cancer. The cancer arises as a result of uncontrolled growth of the squamous cells in the epidermis of the skin. Unlike it's counter part, the basal cell carcinoma which also belongs to the group of non-melanoma cancer, SCC is rapid growing and invasive. SCCs may occur on all areas of the body including the mucous membranes and genitals, but are most common in areas frequently exposed to the sun, such as the rim of the ear, lower lip, face, bald scalp, neck, hands, arms and legs. Wrinkling, changes in pigmentation, and loss of elasticity of the skin are often the telltale signs of sun damage

Pathophysiology

Squamous cell carcinoma is a potentially invasive cancer that arises from the surface epithelium.The development of squamous cell carcinoma is frequently a multistep process. Early lesions tend to be either actinic keratoses, with atypia of the basal keratinocytic layer of the epidermis or squamous cell carcinoma in situ, in which keratinocytic atypia spans the full thickness epidermis.

These precursors are frequently present adjacent to invasive squamous cell carcinomas which invade the dermis as nests, islands, or cords squamous cells with or occasionally as individual cells. Several grading schemes have been developed for squamous cell carcinoma and incorporate the extent of keratinization (a form of differentiation) and nuclear atypia. A widely used scheme divides tumors into well, moderately, or poorly differentiated.

Although poorly differentiated tumors tend to behave more aggressively, well-differentiated tumors can also give rise to metastasis and result in death. Several histologic variants of squamous cell carcinoma have been documented, including verrucous, spindle cell and pseudovascular.

Frequently an actinic keratosis or squamous cell carcinoma overlies the invasive component and the two are focally contiguous. Occasionally squamous tumors arise rapidly, have a crater-form morphology and spontaneously regress. These tumors are known as keratoacanthomas. Some craterform squamous lesions do not regress, but continue to invade and grow and represent invasive squamous cell carcinomas.

Skin

Persons who present with Squamous cell carcinoma of skin may have one of the following risk factors like

• significant sun exposure
• benign lesions like Chalazion
• chronic ulcers.

• 

  Squamous cell skin cancer.

• 

  Squamous cell carcinoma in oral cavity.
  Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

• 

  This patient had two adjacent cancers. The flat black lesion below the antitragus is a malignant melanoma. The white elevated keratotic lesion is a squamous cell carcinoma .

Presentation : They usually notice plaque. Ulcers are commonly seen over the face causing disfiguration. At times they can be exophytic over the lips etc.

Tongue and Esophagus

Persons who present with Squamous cell carcinoma of tongue and esophagus are most likely to have following risk factor

• Tobacco chewing/smoking
• Alcohol Abuse
• Poor dental hygiene

• 

  Squamous cell carcinoma in oral cavity.
  Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

• 

  A large squamous cell carcinoma of the tongue

Presentation : Its usually ulcerated in the lateral part of the tongue, pink - red color. Patient finds tough to eat or swallow. As it bleeds on touch or biting. They have dysphagia/ odynophagia when esophagus is involved. In later stages even liquids are tough to go thru. Swelling of lymph nodes is seen in advanced stages where we can find lumps in the neck

Nasopharynx

Persons who have SCC of this region seldom have any risk factors. It most of the times caused by EBV infection.

Presentation : Patient presents with symptoms from the mass effect of the tumour. They include nasal discharge, bleeding, obstruction; ear infection, deafness , tinnitus are complained. Other important complaints include headache and neck swelling due to lymph nodal spread.

Lungs

Persons who have SCC of lungs usually have risk factors like

• Therapeutic radiation (PUVA for psoriais)
• Tobacco smoking

• 

  Biopsy of a highly differentiated squamous cell carcinoma of the mouth.Haematoxylin & eosin stain.

• 

  Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus

Presentation : Persons who present with SCC of lungs doesn't present usually with any typical symptoms of pulmonary. But in few we may see persistent cough, hemoptysis when it is exophytic and occupies whole of the bronchi which can even lead to recurrent infections.

Penis

Persons who present with Squamous cell carcinoma of penis are most likely to have

• Pre-malignanat lesions (Bowen's disease, Condyloma , Warts)
• Smoking and tobacco chewing

Presentation : Unhealed lesions, subtle indurations may be the intial presentation. Often presentation to the clinic is delayed due to embarrassment most of the times. Warts can be a pre-disposing factor.Large warts lead to infections and necrosis leading to hemorrhages at times.

Others

• 

  Squamous Cell Cancer of the Mouth: Cancer that began along the lower gum line has spread to left submandibular lymph nodes.

• 

  Squamous Cell Cancer of the Mouth: Cancer that began along the lower gum line has spread to left submandibular lymph nodes.

• 

  Recurrent squamous cell carcinoma of the auricle (far left) excised with a stellate incision across the antihelix.

• 

  The final result of the excision.

• 

  Prostate: Squamous cell carcinoma

• 

  Prostate: Squamous cell carcinoma

• 

  Squamous Cell Cancer of the Mouth: Irregular, necrotic appearing tissue on the inside of the mouth due to extensive squamous cell cancer. Patient has limited ability to open his mouth (aka trismus) as a result of the infiltrating cancer.

• 

  Squamous Cell Cancer, Base of Tongue: Note white area with swelling, right base of tongue.

• 

  Squamous cell carcinoma in oral cavity.
  Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

Cervix: Squamous cell carcinoma

{{#ev:youtube|zB47nE-i8dQ}}

{{#ev:youtube|J3kULzKGzws}}

References

Template:WikiDoc Sources