Sinusoidal obstruction syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]

Overview

The most common cause of sinusoidal obstruction syndrome is hematopoietic cell transplantation. Other less common causes include chemotherapeutic agents and pyrrolizidine alkaloids.

Causes

Common causes

Sinusoidal obstruction syndrome is most commonly caused by hematopoietic cell transplantation.^[1]^[2]

Less common causes

Other less common causes include:^[3]

Chemotherapeutic agents such as 6-mercaptopurine, 6-thioguanine, actinomycin D, azathioprine or busulfan etc
Pyrrolizidine alkaloids

References

↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). "Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation". Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.
↑ Valla DC, Cazals-Hatem D (2016). "Sinusoidal obstruction syndrome". Clin Res Hepatol Gastroenterol. 40 (4): 378–85. doi:10.1016/j.clinre.2016.01.006. PMID 27038846.

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[pmid8420443-1] McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.

[pmid12744547-2] Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). "Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation". Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.

[pmid27038846-3] Valla DC, Cazals-Hatem D (2016). "Sinusoidal obstruction syndrome". Clin Res Hepatol Gastroenterol. 40 (4): 378–85. doi:10.1016/j.clinre.2016.01.006. PMID 27038846.

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