Silicosis differential diagnosis
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Other pneumoconiosis
- Silicosis is differentiated from other occupational disease like asbestosis from the history.
Malignant diseases
- Multiple pulmonary nodules that are ≥1 cm in diameter or detected by conventional chest radiography are most likely due to metastatic disease from a malignant solid organ primary tumor [1].[2]
- Multiple pulmonary nodules that are <5 mm in diameter, juxtaposed to either the visceral pleura or an interlobar fissure, and detected incidentally, are more likely to be benign lesions, such as granulomata, scars, or intraparenchymal lymph nodes [3]
Mycobacterial infections
Fungi
- Multiple pulmonary nodules may be due to a fungal infection such as histoplasmosis, coccidioidomycosis, blastomycosis, or cryptococcosis. Invasive aspergillosis is likely in immunocompromised hosts. Nodules due to fungal infection tend to be 0.5 to 3 cm in diameter and do not have a predilection for a specific region of the lungs
Both coal workers' pneumoconiosis and silicosis may evolve into progressive massive fibrosis or conglomerate masses[5]
Parasites
- Paragonimus westermani is a fluke that is endemic in parts of China, Korea, Japan, the Philippines, and Taiwan. Humans acquire the infection by ingesting uncooked fresh water crabs or crayfish that harbor the metacercarial stage of the parasite[6]
References
- ↑ Ginsberg MS, Griff SK, Go BD, Yoo HH, Schwartz LH, Panicek DM (1999). "Pulmonary nodules resected at video-assisted thoracoscopic surgery: etiology in 426 patients". Radiology. 213 (1): 277–82. doi:10.1148/radiology.213.1.r99oc08277. PMID 10540672.
- ↑ Gross BH, Glazer GM, Bookstein FL (1985). "Multiple pulmonary nodules detected by computed tomography: diagnostic implications". J Comput Assist Tomogr. 9 (5): 880–5. PMID 3861629.
- ↑ Ahn MI, Gleeson TG, Chan IH, McWilliams AM, Macdonald SL, Lam S; et al. (2010). "Perifissural nodules seen at CT screening for lung cancer". Radiology. 254 (3): 949–56. doi:10.1148/radiol.09090031. PMID 20177105.
- ↑ Fabreguet I, Francis F, Lemery M, Choudat L, Papo T, Sacre K (2009). "A 76-year-old man with multiple pulmonary nodules". Chest. 135 (4): 1094–7. doi:10.1378/chest.08-2049. PMID 19349406.
- ↑ Gaeta M, Blandino A, Scribano E, Minutoli F, Volta S, Pandolfo I (1999). "Computed tomography halo sign in pulmonary nodules: frequency and diagnostic value". J Thorac Imaging. 14 (2): 109–13. PMID 10210483.
- ↑ BREM TH, COHN HA (1946). "Paragonimus westermanii". Radiology. 46: 511–3. doi:10.1148/46.5.511. PMID 20983083.