Sideroblastic anemia

Revision as of 17:11, 29 July 2011 by Lakshmi Gopalakrishnan (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Sideroblastic anemia
Sideroblastic (microcytic) anemia[1]
ICD-10 D64.0-D64.3
ICD-9 285.0
DiseasesDB 12110
MeSH D000756

Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Sideroblastic anemia is caused by the abnormal production of red blood cells as part of myelodysplastic syndrome, which can evolve into hematological malignancies (especially acute myelogenous leukemia). Thus, the body has iron available, but cannot incorporate it into hemoglobin.

Causes

The common feature of these causes is a failure to completely form heme - whose biosynthesis takes place partly in the mitochondrion. This leads to deposits of iron in the mitochondria that form a ring around the nucleus of the developing red blood cell. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia.

Diagnosis

Ringed sideroblasts are seen in the bone marrow.

Laboratory findings

Treatment

Occasionally, the anemia is so severe that support with transfusion is required. These patients usually do not respond to erythropoietin therapy.[4]Some cases have been reported that the anemia is reversed or heme level is improved through use of moderate to high doses of Pyrodoxine (Vitamin B6.) In severe cases of SBA Bone Marrow Transplant is also an option with limited information about the success rate. Some cases are listed on MedLine and various other medical cites.

See also

References

Template:Hematology Template:SIB


Template:WikiDoc Sources