Sick sinus syndrome overview

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Sick sinus syndrome Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sick sinus syndrome from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Historical Perspective

Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.

Classification

Pathophysiology

Sick sinus syndrome occurs as an improperly propagated signal from the sinoatrial (SA) node. Age-dependent progressive fibrosis of the sinus nodal tissue and Remodeling of sinuatrial node are the potential mechanisms of this abnormally formed signal propagation. MYH6 gene may also be involved in the pathogenesis of this condition.

Causes

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Echocardiography

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