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{{Adrenal insufficiency}}
{{Secondary adrenal insufficiency}}
{{CMG}}
{{CMG}} {{AE}} {{ADS}}
 


==Overview==
==Overview==
 
[[Adrenal gland|Suprarenal gland<nowiki/>s]] were discovered by Eustachius in 1563 and were named as Glandulae renis incumbentes. 35th USA President John F. Kennedy had primary Adrenal insufficiency (Addison's disease).
==Historical Perspective==
==Historical Perspective==
*[[Adrenal gland|Suprarenal glands]] were discovered by Eustachius in 1563 and were named as Glandulae renis incumbentes.<ref name="Loriaux2007">{{cite journal|last1=Loriaux|first1=D Lynn|title=Bartolomeo Eustachi (Eustachius) (1520???1574)|journal=The Endocrinologist|volume=17|issue=4|year=2007|pages=195|issn=1051-2144|doi=10.1097/TEN.0b013e318141f6f4}}</ref>


===Discovery===
*Primary adrenal insufficiency was first discovered by Thomas Addison, an English physician, and scientist, when he described [[Adrenocortical|adrenocortical atrophy]] in 1849 on the autopsy of the [[Adrenal gland|adrenal glands]] of patients, some of which had [[vitiligo]].<ref name="pmid15173338">{{cite journal |vauthors=Pearce JM |title=Thomas Addison (1793-1860) |journal=J R Soc Med |volume=97 |issue=6 |pages=297–300 |year=2004 |pmid=15173338 |pmc=1079500 |doi= |url=}}</ref>
*[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].


*The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
*In 1926, Schmidt was the first to discover the association between adrenalitis and [[thyroiditis]], called [[Schmidt's syndrome]], which was expanded by Carpenter in 1964 to include [[Diabetes mellitus type 1|type 1 diabetes mellitu<nowiki/>s]].
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].


==Outbreaks==
*In 1956, Whittaker found an association between hypo-adrenocortolism, [[hypothyroidism]], and [[candidiasis]].<ref name="urlEndocrinology - E-Book: Adult and Pediatric - J. Larry Jameson, Leslie J. De Groot - Google Books">{{cite web |url=https://books.google.com/books?id=W4dZ-URK8ZoC&pg=PA2703&lpg=PA2703&dq=In+1956,+Whittaker+found+an+association+between+hypo-adrenocortical&source=bl&ots=T9hBIj7u3h&sig=in2ImGw7smTTTynT6Gi6YYh7_yo&hl=en&sa=X&ved=0ahUKEwifzfqA9cXXAhUM6YMKHav0BHoQ6AEIKDAA#v=onepage&q=In%201956%2C%20Whittaker%20found%20an%20association%20between%20hypo-adrenocortical&f=false |title=Endocrinology - E-Book: Adult and Pediatric - J. Larry Jameson, Leslie J. De Groot - Google Books |format= |work= |accessdate=}}</ref>
*There have been several outbreaks of [disease name], which are summarized below:
 
==Landmark Events in the Development of Treatment Strategies==
*In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
 
==Impact on Cultural History==


*In 1997, AIRE gene [[mutation]]<nowiki/>s were first implicated in the pathogenesis of [[Autoimmune polyendocrine syndrome|APS]] ([[Autoimmune polyendocrine syndrome|autoimmune polyglandular syndrome]]).


==Famous Cases==
==Famous Cases==
*The following are a few famous cases of [[disease name]]:


* 35th USA President John F. Kennedy had [[primary adrenal insufficiency]] ([[Addison's disease]]).


Primary adrenal insufficiency was first described in 1849 by Thomas Addison, demonstrating that the adrenal cortex is essential for life. On Thursday, March 15, 1849 almost a century ago, President John Hilton requested that, Dr. Addison, describe his latest medical findings before the South London Medical Society. These were Dr. Addison’s introductory comments, "A remarkable form of anemia, which, although incidentally noticed by various writers, had not attracted, as he thought, by any means the attention it really deserved…It was a state of general anemia incident to adult males, and had for several years past been with him a subject of earnest inquiry and of deep interest. It usually occurs between the ages of 20 and 60; sometimes proceeding to an extreme degree in a few weeks, but more frequently commencing insidiously, and proceeding very slowly, so as to occupy a period of several weeks, or even months, before any very serious alarm is taken either by the patient or by the patient's friends. Its approach is first indicated by a certain amount of languor and restlessness, to which presently succeed a manifest paleness of the countenance, loss of muscular strength, general relaxation or feebleness of the whole frame, and indisposition to, or incapacity for, bodily or mental exertion. These symptoms go on increasing with greater or less rapidity: the face, lips, conjunctive, and external surface of the body, become more and more bloodless; the tongue appears pale and flabby; the heart's action gets exceedingly enfeebled, with a weak, soft, unusually large, but always strikingly compressible pulse; the appetite may or may not be lost; the patient experiences a distressing and increasing sense of helplessness and faintness; the heart is excited, or rendered tumultuous in its action, the breathing painfully hurried by the slightest exertion, whilst the whole surface bears some resemblance to a bad wax figure: the patient is no longer able to rise from his bed; slight edema perhaps shows itself about the ankles; the feeling of faintness and weakness becomes extreme, and he dies either from sheer exhaustion, or death is preceded by signs of passive effusion or cerebral compression.” [1]
==References==
==References==
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[[Category:Endocrinology]]
[[Category:Endocrinology]]
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[[Category:Needs overview]]

Latest revision as of 15:38, 17 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Suprarenal glands were discovered by Eustachius in 1563 and were named as Glandulae renis incumbentes. 35th USA President John F. Kennedy had primary Adrenal insufficiency (Addison's disease).

Historical Perspective

  • Suprarenal glands were discovered by Eustachius in 1563 and were named as Glandulae renis incumbentes.[1]
  • Primary adrenal insufficiency was first discovered by Thomas Addison, an English physician, and scientist, when he described adrenocortical atrophy in 1849 on the autopsy of the adrenal glands of patients, some of which had vitiligo.[2]

Famous Cases

References

  1. Loriaux, D Lynn (2007). "Bartolomeo Eustachi (Eustachius) (1520???1574)". The Endocrinologist. 17 (4): 195. doi:10.1097/TEN.0b013e318141f6f4. ISSN 1051-2144.
  2. Pearce JM (2004). "Thomas Addison (1793-1860)". J R Soc Med. 97 (6): 297–300. PMC 1079500. PMID 15173338.
  3. "Endocrinology - E-Book: Adult and Pediatric - J. Larry Jameson, Leslie J. De Groot - Google Books".


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