Scleroderma: Difference between revisions

	Scleroderma Microchapters
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Diagnostic Study of Choice
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Revision as of 20:27, 7 November 2012

Template:DiseaseDisorder infobox

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

For patient information click here

Synonyms and keywords: Systemic sclerosis; CREST syndrome; limited scleroderma; progressive systemic sclerosis; localized scleroderma; mixed connective disease; morphea - linear; sclerosis, systemic; systemic scleroderma

Click here for The Heart in Scleroderma

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Scleroderma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Template:Diseases of the musculoskeletal system and connective tissue

de:Sklerodermie it:Sclerodermia he:סקלרודרמה nl:Sclerodermie sk:Sklerodermia sv:Sklerodermi

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 '''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
-{{SK}} Systemic sclerosis
+{{SK}} Systemic sclerosis; CREST syndrome; limited scleroderma; progressive systemic sclerosis; localized scleroderma; mixed connective disease; morphea - linear; sclerosis, systemic; systemic scleroderma
 ===Click [[The Heart in Progressive Systemic Sclerosis (Scleroderma)|here]] for The Heart in Scleroderma===
-==Overview==
-== Epidemiology ==
+==[[Scleroderma overview|Overview]]==
-==Pathophysiology==
+==[[Scleroderma historical perspective|Historical Perspective]]==
-==Etiology==
+==[[Scleroderma classification|Classification]]==
-==Types of Scleroderma==
+==[[Scleroderma pathophysiology|Pathophysiology]]==
-==Diagnosis==
+==[[Scleroderma causes|Causes]]==
-Diagnosis is by clinical suspicion, presence of autoantibodies (specifically [[anti-centromere antibodies|anti-centromere]] and anti-scl70/[[anti-topoisomerase antibodies]]) and occasionally by biopsy. Of the antibodies, 90% have a detectable [[anti-nuclear antibody]]. Anti-centromere antibody is more common in the limited form (80-90%) than in the systemic form (10%), and anti-scl70 is more common in the diffuse form (30-40%) and in African-American patients (who are more susceptible to the systemic form).<ref name=JimenezDerk>{{cite journal |author=Jimenez SA, Derk CT |title=Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis |journal=Ann. Intern. Med. |volume=140 |issue=1 |pages=37-50 |year=2004 |pmid=14706971 |doi=}}</ref>
+==[[Scleroderma differential diagnosis|Differentiating Scleroderma from other Diseases]]==
-In 1980 the American College of Rheumatology agreed upon diagnostic criteria for scleroderma.<ref>{{cite journal |author= |title=Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee |journal=Arthritis Rheum. |volume=23 |issue=5 |pages=581-90 |year:1980 |pmid=7378088 |doi=}} Available online at {{cite web | title=Criteria for the Classification of Systemic Sclerosis 1980| work= | url=http://www.rheumatology.org/publications/classification/systsclr.asp | accessdate:5 August 2007}}</ref>
+==[[Scleroderma epidemiology and demographics|Epidemiology and Demographics]]==
-Diffuse scleroderma can cause [[musculoskeletal system|musculoskeletal]], [[lung|pulmonary]], [[gastrointestinal tract|gastrointestinal]], [[kidney|renal]] and other complications.<ref name=Primer/>Patients with larger amounts of cutaneous involvement are more likely to have involvement of the internal tissues and organs.
+==[[Scleroderma risk factors|Risk Factors]]==
-===[[The heart in progressive systemic sclerosis (scleroderma)|Cardiovascular Symptoms]]===
+==[[Scleroderma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-===Skin Symptoms===
+==Diagnosis==
+[[Scleroderma diagnostic criteria|Diagnostic Criteria]] | [[Scleroderma history and symptoms|History and Symptoms]] | [[Scleroderma physical examination|Physical Examination]] | [[Scleroderma laboratory findings|Laboratory Findings]] | [[Scleroderma electrocardiogram|Electrocardiogram]] | [[Scleroderma x ray|X Ray]] | [[Scleroderma CT|CT]] | [[Scleroderma MRI|MRI]] | [[Scleroderma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Scleroderma other imaging findings|Other Imaging Findings]] | [[Scleroderma other diagnostic studies|Other Diagnostic Studies]]
-===Musculoskeletal System Related Symptoms===
-===Respiratory System Symptoms===
-===Gastrointestinal System Related Symptoms===
-===Renal Symptoms===
-== Therapy ==
+==Treatment==
+[[Scleroderma medical therapy|Medical Therapy]] | [[Scleroderma surgery|Surgery]] | [[Scleroderma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Scleroderma future or investigational therapies|Future or Investigational Therapies]]
-===Experimental treatments===
 ==Case Studies==
 [[Scleroderma case study one|Case #1]]
-==References==
-{{Reflist|2}}
-==External links==
-* [http://goldminer.arrs.org/search.php?query=scleroderma Goldminer: Scleroderma]
-* [http://dermnetnz.org/immune/systemic-sclerosis.html DermnetNZ: Systemic sclerosis]
-* [http://www.jsdn.org/ Juvenile Scleroderma Network]
-* [http://www.juvenile-scleroderma.com/ Juvenile Systemic Sclerosis]
-* [http://www.scleroderma.org/ Scleroderma Foundation]
-* [http://www.sclerodermaontario.ca/ Scleroderma Society of Ontario]
-* [http://www.sclero.org/index.html International Scleroderma Network]
-* [http://www.sclerodermaresearch.org/ The Scleroderma Research Foundation]
-* [http://www.sclerodermasociety.co.uk/ UK Scleroderma Society]
-* [http://scleroderma.jhmi.edu/ Scleroderma Information from Johns Hopkins University]
 {{Diseases of the musculoskeletal system and connective tissue}}