Sarcoma botryoides

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Sarcoma botryoides Microchapters
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Overview
Historical perspective
Classification
Pathophysiology
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Differentiating Sarcoma botryoides from other Diseases
Epidemiology and Demographics
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Natural history, Complications, and Prognosis
Diagnosis
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History and Symptoms
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History & Symptoms

The most common clinical finding is vaginal bleeding (Rahaman and Cohen, 2003).

Epidemiology & Demographics

Sarcoma botryoides is found in children under 8 years of age with an average age of onset of symptoms of about 3 years (38.3 months) (Hilgers, 1975). Cases of older women with this condition have also been reported (Reynolds et al 2006)

Surgery

The disease used to be uniformly fatal, with a 5-year survival rate between 10 to 35% (Piver and Rose, 1988). As a result, treatment was radical surgery. New multidrug chemotherapy regimens with or without radiation therapy are now used in combination with less radical surgery with good results, although outcome data are not yet available (Rotmensch and Yamada, 2003).

References

• Hilgers R (1975). "Pelvic exenteration for vaginal embryonal rhabdomyosarcoma: a review". Obstet Gynecol. 45 (2): 175–80. PMID 1090863.
• Piver M, Rose P (1988). "Long-term follow-up and complications of infants with vulvovaginal embryonal rhabdomyosarcoma treated with surgery, radiation therapy, and chemotherapy". Obstet Gynecol. 71 (3 Pt 2): 435–7. PMID 3347430.
• Rahaman, J and Cohen, CJ. Gynecologic Sarcomas. in Holland-Frei Cancer Medicine - 6th Ed. Kufe, DW et al editors. BC Decker Inc, Hamilton, Ontario, 2003.
• Reynolds E, Logani S, Moller K, Horowitz I (2006). "Embryonal rhabdomyosarcoma of the uterus in a postmenopausal woman. Case report and review of the literature". Gynecol Oncol. 103 (2): 736–9. PMID 16684558.CS1 maint: Multiple names: authors list (link)
• Rotmensch, J and Yamada, SD. Neoplasms of the Vulva and Vagina. in Holland-Frei Cancer Medicine - 6th Ed. Kufe, DW et al editors. BC Decker Inc, Hamilton, Ontario, 2003.