Sandbox osteomyelitis: Difference between revisions
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===Penicillin-sensitive streptococci=== | ===Penicillin-sensitive streptococci=== | ||
{{rx|Preferred regimen}} | |||
* [[Penicillin G]] 20 MU/day IV continuously or q4h for 4–6 wk {{or}} [[Ceftriaxone]] 1–2 g IV/IM q24h for 4–6 wk {{or}} [[Cefazolin]] 1–2 g IV q8h for 4–6 wk | |||
</li> | |||
{{rx|Alternative regimen}} | |||
* [[Vancomycin]] 15 mg/kg IV q12h for 4–6 wk {{or}} [[Daptomycin]] 6 mg/kg IV q24h | |||
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==Specific Considerations== | ==Specific Considerations== | ||
Revision as of 18:11, 28 April 2015
Hematogenous Osteomyelitis
Acute Osteomyelitis in Adults
Acute Osteomyelitis in Children
Contiguous Osteomyelitis
Chronic Osteomyelitis in Adults – Pathogen-Based Therapy
Oxacillin-sensitive Staphylococcus aureus
- Vancomycin 15 mg/kg IV q12h for 4–6 wk
OR - Rifampin 600 mg PO qd AND Oxacillin 1.5–2 g IV q4h for 4–6 wk
Oxacillin-resistant Staphylococcus aureus
- Vancomycin 15 mg/kg IV q12h for 4–6 wk OR Daptomycin 6 mg/kg IV q24h
- Linezolid 600 mg PO/IV q12h for 6 wk ± Rifampin 600–900 mg PO qd
OR - Levofloxacin 500–750 mg PO/IV daily ± Rifampin 600–900 mg PO qd
Penicillin-sensitive streptococci
- Penicillin G 20 MU/day IV continuously or q4h for 4–6 wk OR Ceftriaxone 1–2 g IV/IM q24h for 4–6 wk OR Cefazolin 1–2 g IV q8h for 4–6 wk
- Vancomycin 15 mg/kg IV q12h for 4–6 wk OR Daptomycin 6 mg/kg IV q24h
Specific Considerations
Vertebral osteomyelitis
Osteomyelitis in patients with diabetes mellitus
Osteomyelitis in patients with vascular insufficiency
SAPHO syndrome
Chronic recurrent multifocal osteomyelitis
Osteitis Pubis
Osteomyelitis of the Clavicle
Osteomyelitis in Hemodialysis Patients
Osteomyelitis in Patients with Sickle Cell Disease Gaucher’s Disease
Osteomyelitis in Injection Drug Users
Skeletal Mycobacterial Infection
Fungal Osteomyelitis
Brodie’s Abscess
Culture-Negative Osteomyelitis