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::* Preferred regimen (1): [[Daptomycin]] 4–6 mg/kg IV q24h
::* Preferred regimen (1): [[Daptomycin]] 4–6 mg/kg IV q24h
::* Preferred regimen (2): [[Linezolid]] 600 mg PO/IV q12h
::* Preferred regimen (2): [[Linezolid]] 600 mg PO/IV q12h
----


{{PBI|Staphylococcus saprophyticus}}
{{PBI|Staphylococcus saprophyticus}}
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::* Preferred regimen (3): [[TMP-SMX]] 160–800 mg PO bid
::* Preferred regimen (3): [[TMP-SMX]] 160–800 mg PO bid
::* Alternative regimen: [[Levofloxacin]] 500 mg PO qd
::* Alternative regimen: [[Levofloxacin]] 500 mg PO qd
----


{{PBI|Streptococcus anginosus}}
{{PBI|Streptococcus anginosus}}
:* 1. '''Dental abscess'''<ref>{{cite book | last = Abramowicz | first = Mark | title = Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter | publisher = The Medical Letter | location = New Rochelle, N.Y | year = 2011 | isbn = 978-0981527826 }}</ref>
::* Preferred regimen: [[Penicillin V]] 500 mg PO qid
::* Alternative regimen: [[Vancomycin]] 15–20 mg/kg IV q8–12h
:* 2. '''Brain abscess'''
::* Preferred regimen (1): [[Penicillin G]] 18–24 MU/day IV q4–6h
::* Preferred regimen (2): [[Ceftriaxone]] 2 g IV q12h
::* Alternative regimen: [[Vancomycin]] 15–20 mg/kg IV q8–12h
----
{{PBI|Bacillus cereus}}
:* 1. '''Food poisoning'''<ref>{{cite book | last = Bartlett | first = John | title = Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases | publisher = Jones and Bartlett Learning | location = Burlington, MA | year = 2012 | isbn = 978-1449625580 }}</ref>
::* Preferred regimen: Food poisoning is usually self-limited and requires no antibiotic therapy.
:* 2. '''Bacteremia'''
::* Preferred regimen: [[Vancomycin]] 15 mg/kg IV q12h
::* Alternative regimen: [[Clindamycin]] 600 mg IV q8h
::* Note (1): Bacillus cereus is commonly resistant to beta-lactams.
::* Note (2): Pseudobacteremia is transient and usually results from contaminated blood cultures, gloves, or syringes.
:* 3. '''Meningitis or brain abscess'''
::* Preferred regimen: [[Vancomycin]] 15 mg/kg IV q12h
::* Alternative regimen: [[Clindamycin]] 600 mg IV q8h
::* Note: Blood culture isolates are mostly contaminates until proven otherwise, especially in intravenous drug user population.
:* 4. '''Endophthalmitis'''
::* Preferred regimen: [[Clindamycin]] 450 μg intravitreal {{and}} [[Gentamicin]] 400 μg intravitreal {{or}} [[Dexamethasone]] intravitreal {{and}} [[Vancomycin]] 15 mg/kg IV q12h
::* Alternative regimen: [[Clindamycin]] 600 mg IV q8h
::* Note: Ophthalmological consultation, culture ocular fluids, early vitrectomy, and intravitreal antibiotics are necessary.
:* 5. '''Endocarditis'''
::* Preferred regimen: [[Vancomycin]] 15 mg/kg IV q12h
::* Note: Most blood cultures in intravenous drug users are contaminates or represent transient bacteremia.
:* 6. ''' Soft tissue infection'''
::* Preferred regimen: [[Vancomycin]] 15 mg/kg IV q12h
::* Alternative regimen: [[Clindamycin]] 600 mg IV q8h
:* 7. '''Pneumonia'''
::* Preferred regimen: [[Vancomycin]] 15 mg/kg IV q12h
::* Alternative regimen: [[Clindamycin]] 600 mg IV q8h


----


{{PBI|Elizabethkingia meningoseptica}}
:* 1. '''Bacteremia'''<ref>{{Cite journal| doi = 10.1007/s10096-011-1223-0| issn = 1435-4373| volume = 30| issue = 10| pages = 1271–1278| last1 = Hsu| first1 = M.-S.| last2 = Liao| first2 = C.-H.| last3 = Huang| first3 = Y.-T.| last4 = Liu| first4 = C.-Y.| last5 = Yang| first5 = C.-J.| last6 = Kao| first6 = K.-L.| last7 = Hsueh| first7 = P.-R.| title = Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia at a medical center in Taiwan, 1999-2006| journal = European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology| date = 2011-10| pmid = 21461847}}</ref><ref>{{cite book | last = Gilbert | first = David | title = The Sanford guide to antimicrobial therapy | publisher = Antimicrobial Therapy | location = Sperryville, Va | year = 2015 | isbn = 978-1930808843 }}</ref>
::* Preferred regimen (1): [[Levofloxacin]] 750 mg IV/PO q24h
::* Preferred regimen (2): [[TMP-SMX]] 8–10 mg/kg/day IV divided q6–8h
::* Alternative regimen (1): [[Ciprofloxacin]] 400 mg IV q12h
::* Alternative regimen (2): [[TMP-SMX]] 8–10 mg/kg/day IV divided q6–8h


==References==
==References==
{{reflist}}
{{reflist}}

Latest revision as of 05:00, 27 July 2015

  • 1. Methicillin-susceptible strain[1][2]
  • Preferred regimen (1): Nafcillin 1–2 g IV q4-6h (maximum 12 g/day)
  • Preferred regimen (2): Oxacillin 1–2 g IVq4-6h (maximum 12 g/day)
  • Preferred regimen (3): Cefazolin 0.5–2 g IV q6-8h
  • Alternative regimen (1): TMP-SMX 4–5 mg/kg IV q6–12h
  • Alternative regimen (2): Doxycycline 100–200 mg IV q12-24h
  • 2. Methicillin-resistant, Glycopeptide-susceptible strain
  • Preferred regimen: Vancomycin 15–20 mg/kg IV q8–12h
  • 3. Methicillin-resistant, Glycopeptide-resistant strain
  • Preferred regimen (1): Daptomycin 4–6 mg/kg IV q24h
  • Preferred regimen (2): Linezolid 600 mg PO/IV q12h
  • 1. Urinary tract infections[3]
  • 1. Dental abscess[4]
  • 2. Brain abscess
  • Preferred regimen (1): Penicillin G 18–24 MU/day IV q4–6h
  • Preferred regimen (2): Ceftriaxone 2 g IV q12h
  • Alternative regimen: Vancomycin 15–20 mg/kg IV q8–12h
  • 1. Food poisoning[5]
  • Preferred regimen: Food poisoning is usually self-limited and requires no antibiotic therapy.
  • 2. Bacteremia
  • Preferred regimen: Vancomycin 15 mg/kg IV q12h
  • Alternative regimen: Clindamycin 600 mg IV q8h
  • Note (1): Bacillus cereus is commonly resistant to beta-lactams.
  • Note (2): Pseudobacteremia is transient and usually results from contaminated blood cultures, gloves, or syringes.
  • 3. Meningitis or brain abscess
  • Preferred regimen: Vancomycin 15 mg/kg IV q12h
  • Alternative regimen: Clindamycin 600 mg IV q8h
  • Note: Blood culture isolates are mostly contaminates until proven otherwise, especially in intravenous drug user population.
  • 4. Endophthalmitis
  • Preferred regimen: Clindamycin 450 μg intravitreal AND Gentamicin 400 μg intravitreal OR Dexamethasone intravitreal AND Vancomycin 15 mg/kg IV q12h
  • Alternative regimen: Clindamycin 600 mg IV q8h
  • Note: Ophthalmological consultation, culture ocular fluids, early vitrectomy, and intravitreal antibiotics are necessary.
  • 5. Endocarditis
  • Preferred regimen: Vancomycin 15 mg/kg IV q12h
  • Note: Most blood cultures in intravenous drug users are contaminates or represent transient bacteremia.
  • 6. Soft tissue infection
  • 7. Pneumonia
  • Preferred regimen (1): Levofloxacin 750 mg IV/PO q24h
  • Preferred regimen (2): TMP-SMX 8–10 mg/kg/day IV divided q6–8h
  • Alternative regimen (1): Ciprofloxacin 400 mg IV q12h
  • Alternative regimen (2): TMP-SMX 8–10 mg/kg/day IV divided q6–8h

References

  1. ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
  2. ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
  3. ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
  4. ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
  5. ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
  6. ↑ Hsu, M.-S.; Liao, C.-H.; Huang, Y.-T.; Liu, C.-Y.; Yang, C.-J.; Kao, K.-L.; Hsueh, P.-R. (2011-10). "Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia at a medical center in Taiwan, 1999-2006". European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 30 (10): 1271–1278. doi:10.1007/s10096-011-1223-0. ISSN 1435-4373. PMID 21461847. Check date values in: |date= (help)
  7. ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
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