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{{CMG}}; {{AE}} {{Joban Ghuman}}
{{CMG}}; {{AE}} {{Joban Ghuman}}


== monoclonal gammopathy of undetermined significance ==
\Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are produced from a small number of plasma cells in the bone marrow. Plasma cells are a type of white blood cell. Their main job is to make antibodies to fight infection.




 
[[File:Monoclonals-gl.png|Monoclonals-gl|link=Special:FilePath/Monoclonals-gl.png]][[File:Monoclonals-gl.png|thumb|Monoclonals-gl|link=Special:FilePath/Monoclonals-gl.png]]
Practice here.




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Latest revision as of 00:22, 20 January 2021


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Joban Ghuman, M.B.B.S.[2]

monoclonal gammopathy of undetermined significance

\Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are produced from a small number of plasma cells in the bone marrow. Plasma cells are a type of white blood cell. Their main job is to make antibodies to fight infection.


Monoclonals-gl

File:Monoclonals-gl.png
Monoclonals-gl


[1]

High-power field of peripheral blood smear revealing a large, atypical B cell with mild cytoplasmic expansion, coarse chromatin, multiple distinct nucleoli and peripheral vacuolation.Source: Charakidis M. et al, Department of Haematology-Oncology, Royal Hobart Hospital, Tasmania, 7000, Australia.


Classification of Waldenstrom macroglobulinemia (WM) and Related Disorders
Criteria Symptomatic WM Asymptomatic WM IgM-Related Disorders MGUS
IgM monoclonal protein + + + +
Bone marrow infiltration + + - -
Symptoms attributable to IgM + - + -
Symptoms attributable to tumor infiltration + - - -




Reference

  1. Mao Y, Yang D, He J, Krasna MJ (2016). "Epidemiology of Lung Cancer". Surg Oncol Clin N Am. 25 (3): 439–45. doi:10.1016/j.soc.2016.02.001. PMID 27261907.