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| <ref name="pmid22750769">{{cite journal |vauthors=Garg PK, Jain BK, Dubey IB, Sharma AK |title=Generalized lymphadenopathy: physical examination revisited |journal=Ann Saudi Med |volume=33 |issue=3 |pages=298–300 |date=2013 |pmid=22750769 |pmc=6078537 |doi=10.5144/0256-4947.2012.01.7.1525 |url=}}</ref><ref name="pmid24753638">{{cite journal |vauthors=Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A |title=Peripheral lymphadenopathy: approach and diagnostic tools |journal=Iran J Med Sci |volume=39 |issue=2 Suppl |pages=158–70 |date=March 2014 |pmid=24753638 |pmc=3993046 |doi= |url=}}</ref><ref name="pmid12484692">{{cite journal |vauthors=Bazemore AW, Smucker DR |title=Lymphadenopathy and malignancy |journal=Am Fam Physician |volume=66 |issue=11 |pages=2103–10 |date=December 2002 |pmid=12484692 |doi= |url=}}</ref>
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| {{familytree/start |summary=Management of lymphadenopathy}}
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| {{familytree | | | | | | | | | | | | | | Z01 | | | | | | | |Z01='''History'''<div class="mw-collapsible mw-collapsed"><div style="float: left; text-align: left; width: 20em; padding:1em;"><br><div style="float: left; text-align: left; width: 20em; padding:1em;">
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| ❑[[Patient]] [[age]] (specific demographic characteristics ([[age]]) of certain [[malignancy|malignancies]])<br>
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| ❑ Duration of [[lymphadenopathy]] (<2 weeks or >1 year without an increase in size has low malignant potential)<br>
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| ❑ Past medical history of underlying disease, suggestive of [[immunodeficiency]], or recurrent [[infections]]<br>
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| ❑ Sexual history suggestive of infection transmission<br>
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| ❑ Family history of certain malignant disorders ([[breast cancer]], or [[melanoma]])<br>
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| ❑ Exposure to communicable [[infectious disease]]s/ travel to high-risk areas<br>
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| ❑ Environmental exposure such as [[ultraviolet radiation|UV]] (skin cancer risk)/ animals/ occupational exposure <br>
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| ❑ Social history such as tobacco use, alcohol use (head and neck cancers risk)<br>}}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | }}
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| {{familytree | | | | | | | | | | | | | | M01 | | | | | | | M01='''[[Physical exam]]'''<div class="mw-collapsible mw-collapsed"><div style="float: left; text-align: left; width: 20em; padding:1em;"><br>'''Appearance of the [[patient]]'''<br>[[Cachexia]] or surgical scar marks demonstrating previous malignancy treatment<br>
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| [[Vital signs]]<br>
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| *[[Temperature]]: High-grade / low-grade fever may demonstrate [[infection]]. <br>
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| *[[Heart rate]]: [[Tachycardia]] with regular pulse may demonstrate [[infection]]. <br>
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| *[[Respiratory rate]]: [[Tachypnea]] may demonstrate [[respiratory system]] involvement ([[infection]]\ [[metastasis]]).<br>
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| *[[Blood pressure]]: [[Chronic hypertension]] or [[hypotension]] (may indicate [[sepsis]] as a complication).<br>
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| *[[Oxygen saturation]]: may be low if the [[respiratory system]] is affected.}}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | }}
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| {{familytree | | | | | | | | | | | | | |,|^|.| | | | | | |}}
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| {{familytree | | | | | | | | | | | | Y01 | |Y02 | | | | | | |Y01=<div style="float: left; text-align: left; width: 20em; padding:1em;">}}
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| {{familytree | | | | | | | | | | | | |!| | |!| | | | | |}}
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| {{familytree | | | | | | | | |,|-|-| K01 | |!| | | | | | |K01=<div style="float: left; text-align: left; width: 20em; padding:1em;">}}
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| {{familytree | | | | | | | | |!| | |!| | | |!| | | | | |}}
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| {{familytree | | | | | | | | X01 | |`|-|-|v|'| | | | | | |X01=<div style="float: left; text-align: left; width: 20em; padding:1em;">'❑ }}
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| {{familytree | | | | | | | | |!| | | | | |!| | | | | | | |}}
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| {{familytree | | | | | | | | W01 | | | | |!| | | | | | | |W01=<div style="float: left; text-align: left; width: 20em; padding:1em;">}}
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| {{familytree | | | | | | | | | | | | | | A01 | | | | | | | |A01=<div style="float: left; text-align: left; padding:1em;">}}
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| {{familytree | | | | | | | | | | |,|-|-|-|^|-|-|.| | | | }}
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| {{familytree | | | | | | | | | | W01 | | | | | W02 | | | | | | |W01='''Patient is unstable''' <br> |W02='''Patient is stable'''}}
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| {{familytree | | | | | | | | | |!| | | | | | |!| | | | }}
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| {{familytree | | | | | | | | | L01 | | | | | |!| | | | L01=<div style="float: left; text-align: left; line-height: 150% ">}}
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| {{familytree | | | | | | | | | | |`|-|-|-|v|-|'| | | | | }}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | }}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | }}
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| {{familytree | | | | | | | | | | | | | | E01 | | | | | | | | | |E01= }}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | | | |}}
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| {{familytree | | | | | | | | | | | | | | Z02 | | | | | | | | |Z02='}}
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| {{familytree | | | | | | |,|-|-|-|v|-|-|-|+|-|-|-|v|-|-|v|-|-|.| |}}
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| {{familytree | | | | | | W01 | | W02 | | W03 | | W04 | | W05 | | W01= }}
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| {{familytree | | | | | | |!| | | |!| | | |!| | | |!| | | |!| |!| | | | | |}}
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| {{familytree | | | | | | V01 | | V02 | | |!| | | V04 | | V05 |!| |V01=S}}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | | | |!| | | | | |}}
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| {{familytree | | | | | | | | | | | | | | A01 | | | | | | | | |!| | | | |A01=}}
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| {{familytree | | | | | | | | | | | | | | |!| | | | | | | | | |!| | | | | |}}
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| {{familytree | | | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|.| | |!| | | }}
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| {{familytree | | | | | | | C01 |-|-|-|.| | | | | | | | C03 |-|'| | | | | |C01}}
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| {{familytree | | | | | | | |!| | | | |!| | | | | | | | |!| }}
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| {{familytree | | | | | | | M01 | | | M02 | | | | | | | M03 | | M01=}}
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| {{familytree | | | | | | | |!| | | | |!| | | | | | | | |!| | | |}}
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| {{familytree | | | | | | | H01 | | | H02 | | | | |,|-|-|^|.| | | |H01=}}
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| {{familytree | | | | | | | | | | | | | | | | | | K01 | | | K02 | | | | K01=}}
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| {{familytree | | | | | | | | | | | | | | | |,|-|-|^|.| | | |!| | | | |}}
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| {{familytree | | | | | | | | | | | | | | | |!| | | |!| | | J01 | | | | | |J01=}}
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| {{familytree | | | | | | | | | | | | | | | I01 | | I02 |-|'| | | |I01}}
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| {{familytree/end}}
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| Do's
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| [[Patients]] with [[immunodeficiency]] should have a wide differential diagnosis considering[[non-Hodgkin's lymphoma]] and [[Kaposi’s sarcoma]].<ref name="pmid12484692">{{cite journal |vauthors=Bazemore AW, Smucker DR |title=Lymphadenopathy and malignancy |journal=Am Fam Physician |volume=66 |issue=11 |pages=2103–10 |date=December 2002 |pmid=12484692 |doi= |url=}}</ref>
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| Dont's
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| *Physical examination should not be missed as a finding may change the course of differential diagnosis. Missing the physical exam may lead to unnecessary investigations and unnecessary delays.<ref name="pmid22750769">{{cite journal |vauthors=Garg PK, Jain BK, Dubey IB, Sharma AK |title=Generalized lymphadenopathy: physical examination revisited |journal=Ann Saudi Med |volume=33 |issue=3 |pages=298–300 |date=2013 |pmid=22750769 |pmc=6078537 |doi=10.5144/0256-4947.2012.01.7.1525 |url=}}</ref>
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| *Fine-needle aspiration biopsy (FNAC) or excisional biopsy is the gold standard for tissue diagnosis and evaluation for LAD.<ref name="pmid24753638">{{cite journal |vauthors=Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A |title=Peripheral lymphadenopathy: approach and diagnostic tools |journal=Iran J Med Sci |volume=39 |issue=2 Suppl |pages=158–70 |date=March 2014 |pmid=24753638 |pmc=3993046 |doi= |url=}}</ref>
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