Salivary gland tumor staging

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Stage	Tumor location
TX	Primary tumor cannot be assessed
T0	No evidence of a primary tumor
T1	Tumor ≤2 cm in greatest dimension without extraparenchymal extension.
T2	Tumor >2 cm but ≤4 cm in greatest dimension without extraparenchymal extension
T3	Tumor >4 cm and/or tumor having extraparenchymal extension.
T4a	Moderately advanced disease. Tumor invades skin, mandible, ear canal, and/or facial nerve.
T4b	Very advanced disease. Tumor invades skull base and/or pterygoid plates and/or encases carotid artery.

N classification	Nodal Mass
NX	Regional lymph nodes cannot be assessed
N0	No regional lymph node metastasis.
N1	Metastasis in a single ipsilateral lymph node, ≤3 cm in greatest dimension.
N2	Metastasis in a single ipsilateral lymph node, >3 cm but ≤6 cm in greatest dimension. Metastases in multiple ipsilateral lymph nodes, ≤6 cm in greatest dimension. Metastases in bilateral or contralateral lymph nodes, ≤6 cm in greatest dimension.
N2a	Metastasis in a single ipsilateral lymph node, >3 cm but ≤6 cm in greatest dimension
N2b	Metastases in multiple ipsilateral lymph nodes, ≤6 cm in greatest dimension.
N2c	Metastases in bilateral or contralateral lymph nodes, ≤6 cm in greatest dimension.
N3	Metastases in bilateral or contralateral lymph nodes, ≤6 cm in greatest dimension.

N classification	Nodal Mass
M0	No distant metastasis
M1	Distant metastasis

Stage T N M aReprinted with permission from AJCC: Major salivary glands (parotid, submandibular, and sublingual) . In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 79-86. I T1 N0 M0 II T2 N0 M0 III T3 N0 M0 T1 N1 M0 T2 N1 M0 T3 N1 M0 IVA T4a N0 M0 T4a N1 M0 T1 N2 M0 T2 N2 M0 T3 N2 M0 T4a N2 M0 IVB T4b Any N M0 Any T N3 M0 IVC Any T Any N M1

Stage	T	N	M
Stage 1	T1	N0	M0
Stage II	T2	N0	M0
Stage III	T3 T1 T2 T3	N0 N1 N1 N1	M0 M0 M0 M0
Stage IVA	T4a T4a T1 T2 T3 T4a	N0 N1 N2 N2 N2 N2	M0 M0 M0 M0 M0 M0
Stage IVB	T4b Any T	Any N N3	M0 M0
Stage IVC	Any T	Any N	M1