Salivary gland tumor pathophysiology: Difference between revisions

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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Pleomorphic adenoma
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Pleomorphic adenoma
| style="padding: 5px 5px; background: #DCDCDC; |Variable
| style="padding: 5px 5px; background: #F5F5F5;"  |Variable
| style="padding: 5px 5px; background: #DCDCDC; |mixed proportion; must include:  
| style="padding: 5px 5px; background: #F5F5F5;"  |mixed proportion; must include:  
*myoepithelium
*myoepithelium
*mesenchymal stroma
*mesenchymal stroma
*epithelium (ductal cells) or
*epithelium (ductal cells) or
*chondromyxoid stroma
*chondromyxoid stroma
| style="padding: 5px 5px; background: #DCDCDC;  |Variable
| style="padding: 5px 5px; background: #F5F5F5;" |Variable
| style="padding: 5px 5px; background: #DCDCDC;  |Variable
| style="padding: 5px 5px; background: #F5F5F5;" |Variable
| style="padding: 5px 5px; background: #DCDCDC;  |Plasmacytoid
| style="padding: 5px 5px; background: #F5F5F5;" |Plasmacytoid
| style="padding: 5px 5px; background: #DCDCDC;  |Adenoid cystic carcinoma
| style="padding: 5px 5px; background: #F5F5F5;" |Adenoid cystic carcinoma
| style="padding: 5px 5px; background: #DCDCDC;  |Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells
| style="padding: 5px 5px; background: #F5F5F5;" |Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Warthin tumor
| style="padding: 5px 5px; background: #F5F5F5;"  font-weight: bold" |Warthin tumor
| style="padding: 5px 5px; background: #DCDCDC; |Papillary, bilayer
| style="padding: 5px 5px; background: #F5F5F5;" |Papillary, bilayer
| style="padding: 5px 5px; background: #DCDCDC; |Cuboid (basal), columnar (apical)
| style="padding: 5px 5px; background: #F5F5F5;" |Cuboid (basal), columnar (apical)
| style="padding: 5px 5px; background: #DCDCDC; |Clearly seen
| style="padding: 5px 5px; background: #F5F5F5;" |Clearly seen
| style="padding: 5px 5px; background: #DCDCDC; |Eosinophilic, abundant
| style="padding: 5px 5px; background: #F5F5F5;" |Eosinophilic, abundant
| style="padding: 5px 5px; background: #DCDCDC; |Unremarkable
| style="padding: 5px 5px; background: #F5F5F5;" |Unremarkable
| style="padding: 5px 5px; background: #DCDCDC; |Sebaceous lymphadenoma
| style="padding: 5px 5px; background: #F5F5F5;" |Sebaceous lymphadenoma
| style="padding: 5px 5px; background: #DCDCDC; |AKA papillary cystadenoma lymphomatosum
| style="padding: 5px 5px; background: #F5F5F5;" |AKA papillary cystadenoma lymphomatosum
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold"  |Basal cell adenoma
| style="padding: 5px 5px; background: #F5F5F5;"  font-weight: bold"  |Basal cell adenoma
| style="padding: 5px 5px; background: #DCDCDC; |variable, islands surrounded by hyaline bands, lesion encapsulated
| style="padding: 5px 5px; background: #F5F5F5;"  |variable, islands surrounded by hyaline bands, lesion encapsulated
| style="padding: 5px 5px; background: #DCDCDC; |Basaloid
| style="padding: 5px 5px; background: #F5F5F5;"  |Basaloid
| style="padding: 5px 5px; background: #DCDCDC; |Subtle
| style="padding: 5px 5px; background: #F5F5F5;"  |Subtle
| style="padding: 5px 5px; background: #DCDCDC; |Scant, hyperchromatic
| style="padding: 5px 5px; background: #F5F5F5;"  |Scant, hyperchromatic
| style="padding: 5px 5px; background: #DCDCDC; |Granular
| style="padding: 5px 5px; background: #F5F5F5;"  |Granular
| style="padding: 5px 5px; background: #DCDCDC; |Basal cell adenocarcinoma
| style="padding: 5px 5px; background: #F5F5F5;"  |Basal cell adenocarcinoma
| style="padding: 5px 5px; background: #DCDCDC; |
| style="padding: 5px 5px; background: #F5F5F5;"  |
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Canalicular adenoma
| style="padding: 5px 5px; background: #F5F5F5;"  font-weight: bold" |Canalicular adenoma
| style="padding: 5px 5px; background: #DCDCDC;  |Chains of cells
| style="padding: 5px 5px; background: #F5F5F5;" |Chains of cells
| style="padding: 5px 5px; background: #DCDCDC; |Cuboid or columnar
| style="padding: 5px 5px; background: #F5F5F5;"  |Cuboid or columnar
| style="padding: 5px 5px; background: #DCDCDC;  |Subtle
| style="padding: 5px 5px; background: #F5F5F5;" |Subtle
| style="padding: 5px 5px; background: #DCDCDC;  |Scant, hyperchromatic
| style="padding: 5px 5px; background: #F5F5F5;" |Scant, hyperchromatic
| style="padding: 5px 5px; background: #DCDCDC; |Granular
| style="padding: 5px 5px; background: #F5F5F5;"  |Granular
| style="padding: 5px 5px; background: #DCDCDC;  |Basal cell adenoma
| style="padding: 5px 5px; background: #F5F5F5;" |Basal cell adenoma
| style="padding: 5px 5px; background: #DCDCDC; |Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63-
| style="padding: 5px 5px; background: #F5F5F5;"  |Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Sialoblastoma
| style="padding: 5px 5px; background: #F5F5F5;"  font-weight: bold" |Sialoblastoma
| style="padding: 5px 5px; background: #DCDCDC;  |variable, islands surrounded by loose fibrous stroma
| style="padding: 5px 5px; background: #F5F5F5;" |variable, islands surrounded by loose fibrous stroma
| style="padding: 5px 5px; background: #DCDCDC;  |Basaloid
| style="padding: 5px 5px; background: #F5F5F5;" |Basaloid
| style="padding: 5px 5px; background: #DCDCDC; |Subtle
| style="padding: 5px 5px; background: #F5F5F5;"  |Subtle
| style="padding: 5px 5px; background: #DCDCDC; |Scant, hyperchromatic
| style="padding: 5px 5px; background: #F5F5F5;"  |Scant, hyperchromatic
| style="padding: 5px 5px; background: #DCDCDC; |Granular
| style="padding: 5px 5px; background: #F5F5F5;"  |Granular
| style="padding: 5px 5px; background: #DCDCDC;  |Adenoid cystic carcinoma
| style="padding: 5px 5px; background: #F5F5F5;" |Adenoid cystic carcinoma
| style="padding: 5px 5px; background: #DCDCDC;  |Basal cell adenocarcinoma
| style="padding: 5px 5px; background: #F5F5F5;" |Basal cell adenocarcinoma
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|}
|}

Revision as of 04:13, 8 November 2015

Salivary gland tumor Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

The pathophysiology of salivary gland tumors depends on the histological subtype.

Pathophysiology
Entity Architecture Morphology Cell borders Cytoplasm Nucleus Differential Diagnosis Other
Pleomorphic adenoma Variable mixed proportion; must include:
  • myoepithelium
  • mesenchymal stroma
  • epithelium (ductal cells) or
  • chondromyxoid stroma
 Variable Variable Plasmacytoid Adenoid cystic carcinoma Occasionally encapsulated, mixed proportion of glandular, myoepithelial and mesenchymal cells
Warthin tumor Papillary, bilayer Cuboid (basal), columnar (apical) Clearly seen Eosinophilic, abundant Unremarkable Sebaceous lymphadenoma AKA papillary cystadenoma lymphomatosum
Basal cell adenoma variable, islands surrounded by hyaline bands, lesion encapsulated Basaloid Subtle Scant, hyperchromatic Granular Basal cell adenocarcinoma
Canalicular adenoma Chains of cells Cuboid or columnar Subtle Scant, hyperchromatic Granular Basal cell adenoma Exclusively oral cavity, 80% in upper lip; immunohistochemistry: p63-
Sialoblastoma variable, islands surrounded by loose fibrous stroma Basaloid Subtle Scant, hyperchromatic Granular Adenoid cystic carcinoma Basal cell adenocarcinoma

References

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