STK11

Serine/threonine kinase 11
Identifiers
Symbols	STK11 ; LKB1; PJS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 393
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE STK11 41657 at tn.png
File:PBB GE STK11 204292 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serine/threonine kinase 11, also known as STK11, is a human gene.

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Yoo LI, Chung DC, Yuan J (2002). "LKB1--a master tumour suppressor of the small intestine and beyond". Nat. Rev. Cancer. 2 (7): 529–35. doi:10.1038/nrc843. PMID 12094239.CS1 maint: Multiple names: authors list (link)
• Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.CS1 maint: Multiple names: authors list (link)
• Katajisto P, Vallenius T, Vaahtomeri K; et al. (2007). "The LKB1 tumor suppressor kinase in human disease". Biochim. Biophys. Acta. 1775 (1): 63–75. doi:10.1016/j.bbcan.2006.08.003. PMID 17010524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hemminki A, Tomlinson I, Markie D; et al. (1997). "Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis". Nat. Genet. 15 (1): 87–90. doi:10.1038/ng0197-87. PMID 8988175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jenne DE, Reimann H, Nezu J; et al. (1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase". Nat. Genet. 18 (1): 38–43. doi:10.1038/ng0198-38. PMID 9425897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hemminki A, Markie D, Tomlinson I; et al. (1998). "A serine/threonine kinase gene defective in Peutz-Jeghers syndrome". Nature. 391 (6663): 184–7. doi:10.1038/34432. PMID 9428765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bignell GR, Barfoot R, Seal S; et al. (1998). "Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer". Cancer Res. 58 (7): 1384–6. PMID 9537235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakagawa H, Koyama K, Miyoshi Y; et al. (1998). "Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome". Hum. Genet. 103 (2): 168–72. PMID 9760200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehenni H, Gehrig C, Nezu J; et al. (1999). "Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity". Am. J. Hum. Genet. 63 (6): 1641–50. PMID 9837816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guldberg P, thor Straten P, Ahrenkiel V; et al. (1999). "Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma". Oncogene. 18 (9): 1777–80. doi:10.1038/sj.onc.1202486. PMID 10208439.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su GH, Hruban RH, Bansal RK; et al. (1999). "Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers". Am. J. Pathol. 154 (6): 1835–40. PMID 10362809.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Westerman AM, Entius MM, Boor PP; et al. (1999). "Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families". Hum. Mutat. 13 (6): 476–81. doi:10.1002/(SICI)1098-1004(1999)13:6<476::AID-HUMU7>3.0.CO;2-2. PMID 10408777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Gordan JD, Williamson B; et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. PMID 10508479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins SP, Reoma JL, Gamm DM, Uhler MD (2000). "LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo". Biochem. J. 345 Pt 3: 673–80. PMID 10642527.CS1 maint: Multiple names: authors list (link)
• Sapkota GP, Kieloch A, Lizcano JM; et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karuman P, Gozani O, Odze RD; et al. (2001). "The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death". Mol. Cell. 7 (6): 1307–19. PMID 11430832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marignani PA, Kanai F, Carpenter CL (2001). "LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest". J. Biol. Chem. 276 (35): 32415–8. doi:10.1074/jbc.C100207200. PMID 11445556.CS1 maint: Multiple names: authors list (link)
• Abed AA, Günther K, Kraus C; et al. (2002). "Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4)". Hum. Mutat. 18 (5): 397–410. doi:10.1002/humu.1211. PMID 11668633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato N, Rosty C, Jansen M; et al. (2001). "STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas". Am. J. Pathol. 159 (6): 2017–22. PMID 11733352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.