SPTAN1

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
File:PBB Protein SPTAN1 image.jpg PDB rendering based on 1aey.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1aey​, 1aj3​, 1bk2​, 1cun​, 1e6g​, 1e6h​, 1e7o​, 1h8k​, 1hd3​, 1m8m​, 1pwt​, 1qkw​, 1qkx​, 1shg​, 1u06​, 1u4q​, 1u5p​, 1uue​, 2cdt​, 2f2v​, 2f2w​, 2f2x​, 2fot​, 2jm8​, 2jm9​, 2jma​, 2nuz​
Identifiers
Symbols	SPTAN1 ; (ALPHA)II-SPECTRIN; FLJ44613
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2353
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SPTAN1 208611 s at tn.png
File:PBB GE SPTAN1 215235 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), also known as SPTAN1, is a human gene.

Further reading

• Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and investigative medicine. Médecine clinique et experimentale. 22 (5): 195–206. PMID 10579058.
• Hayashi Y, Arakaki R, Ishimaru N (2003). "The role of caspase cascade on the development of primary Sjögren's syndrome". J. Med. Invest. 50 (1–2): 32–8. PMID 12630566.CS1 maint: Multiple names: authors list (link)
• Bennett V (1979). "Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues". Nature. 281 (5732): 597–9. PMID 492324.
• Frappier T, Stetzkowski-Marden F, Pradel LA (1991). "Interaction domains of neurofilament light chain and brain spectrin". Biochem. J. 275 ( Pt 2): 521–7. PMID 1902666.CS1 maint: Multiple names: authors list (link)
• Bennett AF, Hayes NV, Baines AJ (1991). "Site specificity in the interactions of synapsin 1 with tubulin". Biochem. J. 276 ( Pt 3): 793–9. PMID 1905928.CS1 maint: Multiple names: authors list (link)
• Davis LH, Bennett V (1990). "Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin". J. Biol. Chem. 265 (18): 10589–96. PMID 2141335.
• Moon RT, McMahon AP (1990). "Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin". J. Biol. Chem. 265 (8): 4427–33. PMID 2307671.
• Langley RC, Cohen CM (1986). "Association of spectrin with desmin intermediate filaments". J. Cell. Biochem. 30 (2): 101–9. doi:10.1002/jcb.240300202. PMID 2939097.
• Cianci CD, Giorgi M, Morrow JS (1988). "Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3". J. Cell. Biochem. 37 (3): 301–15. doi:10.1002/jcb.240370305. PMID 2970468.CS1 maint: Multiple names: authors list (link)
• Steiner JP, Bennett V (1988). "Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin". J. Biol. Chem. 263 (28): 14417–25. PMID 2971657.
• Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin". J. Biol. Chem. 262 (3): 1320–5. PMID 3027087.
• McMahon AP, Giebelhaus DH, Champion JE; et al. (1987). "cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin". Differentiation. 34 (1): 68–78. PMID 3038643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frappier T, Regnouf F, Pradel LA (1988). "Binding of brain spectrin to the 70-kDa neurofilament subunit protein". Eur. J. Biochem. 169 (3): 651–7. PMID 3121319.CS1 maint: Multiple names: authors list (link)
• Leto TL, Fortugno-Erikson D, Barton D; et al. (1988). "Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species". Mol. Cell. Biol. 8 (1): 1–9. PMID 3336352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McMahon AP, Moon RT (1988). "Structure and evolution of a non-erythroid spectrin, human alpha-fodrin". Biochem. Soc. Trans. 15 (5): 804–7. PMID 3691949.
• Lundberg S, Björk J, Löfvenberg L, Backman L (1995). "Cloning, expression and characterization of two putative calcium-binding sites in human non-erythroid alpha-spectrin". Eur. J. Biochem. 230 (2): 658–65. PMID 7607240.CS1 maint: Multiple names: authors list (link)
• Hughes CA, Bennett V (1995). "Adducin: a physical model with implications for function in assembly of spectrin-actin complexes". J. Biol. Chem. 270 (32): 18990–6. PMID 7642559.
• Gregorio CC, Repasky EA, Fowler VM, Black JD (1994). "Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta". J. Cell Biol. 125 (2): 345–58. PMID 8163551.CS1 maint: Multiple names: authors list (link)
• Li X, Bennett V (1996). "Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes". J. Biol. Chem. 271 (26): 15695–702. PMID 8663089.
• Stabach PR, Cianci CD, Glantz SB; et al. (1997). "Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility". Biochemistry. 36 (1): 57–65. doi:10.1021/bi962034i. PMID 8993318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)