SPINT1

Serine peptidase inhibitor, Kunitz type 1
File:PBB Protein SPINT1 image.jpg PDB rendering based on 1yc0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yc0​
Identifiers
Symbols	SPINT1 ; HAI; HAI1; MANSC2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9653
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPINT1 202826 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serine peptidase inhibitor, Kunitz type 1, also known as SPINT1, is a human gene.

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.

Further reading

• Dahl M, Hersh CP, Ly NP; et al. (2005). "The protease inhibitor PI*S allele and COPD: a meta-analysis". Eur. Respir. J. 26 (1): 67–76. doi:10.1183/09031936.05.00135704. PMID 15994391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimomura T, Denda K, Kitamura A; et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. PMID 9045658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada T, Tsujioka Y, Taguchi J; et al. (1998). "White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues". Exp. Neurol. 153 (1): 60–4. doi:10.1006/exnr.1998.6874. PMID 9743567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kataoka H, Suganuma T, Shimomura T; et al. (1999). "Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues". J. Histochem. Cytochem. 47 (5): 673–82. PMID 10219059.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin CY, Anders J, Johnson M, Dickson RB (1999). "Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk". J. Biol. Chem. 274 (26): 18237–42. PMID 10373425.CS1 maint: Multiple names: authors list (link)
• Shimomura T, Denda K, Kawaguchi T; et al. (2000). "Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form". J. Biochem. 126 (5): 821–8. PMID 10544273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Itoh H, Yamauchi M, Kataoka H; et al. (2000). "Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes". Eur. J. Biochem. 267 (11): 3351–9. PMID 10824123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kataoka H, Shimomura T, Kawaguchi T; et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kataoka H, Meng JY, Itoh H; et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta". Histochem. Cell Biol. 114 (6): 469–75. PMID 11201608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oberst M, Anders J, Xie B; et al. (2001). "Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo". Am. J. Pathol. 158 (4): 1301–11. PMID 11290548.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kirchhofer D, Peek M, Li W; et al. (2003). "Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1". J. Biol. Chem. 278 (38): 36341–9. doi:10.1074/jbc.M304643200. PMID 12815039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shia S, Stamos J, Kirchhofer D; et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B". J. Mol. Biol. 346 (5): 1335–49. doi:10.1016/j.jmb.2004.12.048. PMID 15713485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan B, Wu TD, Li W, Kirchhofer D (2005). "Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin". J. Biol. Chem. 280 (41): 34513–20. doi:10.1074/jbc.M502119200. PMID 16103126.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)