SPINT1: Difference between revisions

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'''Kunitz-type protease inhibitor 1''' is an [[enzyme]] that in humans is encoded by the ''SPINT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6692| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SPINT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yc0.
| PDB = {{PDB2|1yc0}}
| Name = Serine peptidase inhibitor, Kunitz type 1
| HGNCid = 11246
| Symbol = SPINT1
| AltSymbols =; HAI; HAI1; MANSC2
| OMIM = 605123
| ECnumber = 
| Homologene = 9653
| MGIid = 1338033
| GeneAtlas_image1 = PBB_GE_SPINT1_202826_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}}
| Process = {{GNF_GO|id=GO:0001763 |text = morphogenesis of a branching structure}} {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6692
    | Hs_Ensembl = ENSG00000166145
    | Hs_RefseqProtein = NP_001027539
    | Hs_RefseqmRNA = NM_001032367
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 38923538
    | Hs_GenLoc_end = 38937144
    | Hs_Uniprot = O43278
    | Mm_EntrezGene = 20732
    | Mm_Ensembl = ENSMUSG00000027315
    | Mm_RefseqmRNA = NM_016907
    | Mm_RefseqProtein = NP_058603
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 118928846
    | Mm_GenLoc_end = 118940947
    | Mm_Uniprot = Q68G55
  }}
}}
'''Serine peptidase inhibitor, Kunitz type 1''', also known as '''SPINT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6692| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6692| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Dahl M, Hersh CP, Ly NP, ''et al.'' |title=The protease inhibitor PI*S allele and COPD: a meta-analysis. |journal=Eur. Respir. J. |volume=26 |issue= 1 |pages= 67-76 |year= 2005 |pmid= 15994391 |doi= 10.1183/09031936.05.00135704 }}
*{{cite journal   |vauthors=Dahl M, Hersh CP, Ly NP, etal |title=The protease inhibitor PI*S allele and COPD: a meta-analysis. |journal=Eur. Respir. J. |volume=26 |issue= 1 |pages= 67–76 |year= 2005 |pmid= 15994391 |doi= 10.1183/09031936.05.00135704 }}
*{{cite journal | author=Shimomura T, Denda K, Kitamura A, ''et al.'' |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370-6 |year= 1997 |pmid= 9045658 |doi=  }}
*{{cite journal   |vauthors=Shimomura T, Denda K, Kitamura A, etal |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370–6 |year= 1997 |pmid= 9045658 |doi=10.1074/jbc.272.10.6370 }}
*{{cite journal | author=Yamada T, Tsujioka Y, Taguchi J, ''et al.'' |title=White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues. |journal=Exp. Neurol. |volume=153 |issue= 1 |pages= 60-4 |year= 1998 |pmid= 9743567 |doi= 10.1006/exnr.1998.6874 }}
*{{cite journal   |vauthors=Yamada T, Tsujioka Y, Taguchi J, etal |title=White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues. |journal=Exp. Neurol. |volume=153 |issue= 1 |pages= 60–4 |year= 1998 |pmid= 9743567 |doi= 10.1006/exnr.1998.6874 }}
*{{cite journal | author=Kataoka H, Suganuma T, Shimomura T, ''et al.'' |title=Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. |journal=J. Histochem. Cytochem. |volume=47 |issue= 5 |pages= 673-82 |year= 1999 |pmid= 10219059 |doi=  }}
*{{cite journal   |vauthors=Kataoka H, Suganuma T, Shimomura T, etal |title=Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. |journal=J. Histochem. Cytochem. |volume=47 |issue= 5 |pages= 673–82 |year= 1999 |pmid= 10219059 |doi=  10.1177/002215549904700509}}
*{{cite journal  | author=Lin CY, Anders J, Johnson M, Dickson RB |title=Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18237-42 |year= 1999 |pmid= 10373425 |doi= }}
*{{cite journal  | vauthors=Lin CY, Anders J, Johnson M, Dickson RB |title=Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18237–42 |year= 1999 |pmid= 10373425 |doi=10.1074/jbc.274.26.18237  }}
*{{cite journal | author=Shimomura T, Denda K, Kawaguchi T, ''et al.'' |title=Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. |journal=J. Biochem. |volume=126 |issue= 5 |pages= 821-8 |year= 2000 |pmid= 10544273 |doi=  }}
*{{cite journal   |vauthors=Shimomura T, Denda K, Kawaguchi T, etal |title=Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. |journal=J. Biochem. |volume=126 |issue= 5 |pages= 821–8 |year= 2000 |pmid= 10544273 |doi=  10.1093/oxfordjournals.jbchem.a022522}}
*{{cite journal | author=Itoh H, Yamauchi M, Kataoka H, ''et al.'' |title=Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. |journal=Eur. J. Biochem. |volume=267 |issue= 11 |pages= 3351-9 |year= 2000 |pmid= 10824123 |doi=  }}
*{{cite journal   |vauthors=Itoh H, Yamauchi M, Kataoka H, etal |title=Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. |journal=Eur. J. Biochem. |volume=267 |issue= 11 |pages= 3351–9 |year= 2000 |pmid= 10824123 |doi=10.1046/j.1432-1327.2000.01368.x }}
*{{cite journal | author=Kataoka H, Shimomura T, Kawaguchi T, ''et al.'' |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453-62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 }}
*{{cite journal   |vauthors=Kataoka H, Shimomura T, Kawaguchi T, etal |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453–62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 }}
*{{cite journal | author=Kataoka H, Meng JY, Itoh H, ''et al.'' |title=Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta. |journal=Histochem. Cell Biol. |volume=114 |issue= 6 |pages= 469-75 |year= 2001 |pmid= 11201608 |doi=  }}
*{{cite journal   |vauthors=Kataoka H, Meng JY, Itoh H, etal |title=Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta. |journal=Histochem. Cell Biol. |volume=114 |issue= 6 |pages= 469–75 |year= 2001 |pmid= 11201608 |doi=  10.1007/s004180000228}}
*{{cite journal | author=Oberst M, Anders J, Xie B, ''et al.'' |title=Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. |journal=Am. J. Pathol. |volume=158 |issue= 4 |pages= 1301-11 |year= 2001 |pmid= 11290548 |doi=  }}
*{{cite journal   |vauthors=Oberst M, Anders J, Xie B, etal |title=Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. |journal=Am. J. Pathol. |volume=158 |issue= 4 |pages= 1301–11 |year= 2001 |pmid= 11290548 |doi=  10.1016/S0002-9440(10)64081-3| pmc=1891898  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kirchhofer D, Peek M, Li W, ''et al.'' |title=Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36341-9 |year= 2003 |pmid= 12815039 |doi= 10.1074/jbc.M304643200 }}
*{{cite journal   |vauthors=Kirchhofer D, Peek M, Li W, etal |title=Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36341–9 |year= 2003 |pmid= 12815039 |doi= 10.1074/jbc.M304643200 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Shia S, Stamos J, Kirchhofer D, ''et al.'' |title=Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1335-49 |year= 2005 |pmid= 15713485 |doi= 10.1016/j.jmb.2004.12.048 }}
*{{cite journal   |vauthors=Shia S, Stamos J, Kirchhofer D, etal |title=Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1335–49 |year= 2005 |pmid= 15713485 |doi= 10.1016/j.jmb.2004.12.048 }}
*{{cite journal  | author=Fan B, Wu TD, Li W, Kirchhofer D |title=Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34513-20 |year= 2005 |pmid= 16103126 |doi= 10.1074/jbc.M502119200 }}
*{{cite journal  | vauthors=Fan B, Wu TD, Li W, Kirchhofer D |title=Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34513–20 |year= 2005 |pmid= 16103126 |doi= 10.1074/jbc.M502119200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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{{refend}}
{{refend}}
{{PDB Gallery|geneid=6692}}
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[[Category:Serine protease inhibitors]]
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Revision as of 06:55, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kunitz-type protease inhibitor 1 is an enzyme that in humans is encoded by the SPINT1 gene.[1]

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SPINT1 serine peptidase inhibitor, Kunitz type 1".

Further reading



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