The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]
References
↑Richardson RT, Sivashanmugam P, Hall SH, Hamil KG, Moore PA, Ruben SM, French FS, O'Rand M (Jun 2001). "Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis". Gene. 270 (1–2): 93–102. doi:10.1016/S0378-1119(01)00462-0. PMID11404006.
Wang Z, Widgren EE, Sivashanmugam P, et al. (2005). "Association of eppin with semenogelin on human spermatozoa". Biol. Reprod. 72 (5): 1064–70. doi:10.1095/biolreprod.104.036483. PMID15590901.
Yenugu S, Richardson RT, Sivashanmugam P, et al. (2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif". Biol. Reprod. 71 (5): 1484–90. doi:10.1095/biolreprod.104.031567. PMID15229136.
Sivashanmugam P, Hall SH, Hamil KG, et al. (2003). "Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2". Gene. 312: 125–34. doi:10.1016/S0378-1119(03)00608-5. PMID12909348.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
