SOD2

Superoxide dismutase 2, mitochondrial
File:PBB Protein SOD2 image.jpg PDB rendering based on 1ap5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ap5​, 1ap6​, 1em1​, 1ja8​, 1luv​, 1luw​, 1msd​, 1n0j​, 1n0n​, 1pl4​, 1pm9​, 1qnm​, 1szx​, 1var​, 1xdc​, 1xil​, 1zsp​, 1zte​, 1zuq​, 2adp​, 2adq​, 2gds​, 2p4k​
Identifiers
Symbols	SOD2 ; IPO-B; MNSOD; Mn-SOD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 530
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SOD2 215223 s at tn.png
File:PBB GE SOD2 216841 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Superoxide dismutase 2, mitochondrial, also known as SOD2, is a human gene.

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of the mitochondrial electron transport chain and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Mice lacking Sod2 die shortly after birth, indicating that the unchecked levels of superoxide are incompatible with mammalian life. However, mice 50% deficient in Sod2 have a normal lifespan and minimal phenotypic defects.

Further reading

• Zelko IN, Mariani TJ, Folz RJ (2003). "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression". Free Radic. Biol. Med. 33 (3): 337–49. PMID 12126755.CS1 maint: Multiple names: authors list (link)
• Faraci FM, Didion SP (2005). "Vascular protection: superoxide dismutase isoforms in the vessel wall". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1367–73. doi:10.1161/01.ATV.0000133604.20182.cf. PMID 15166009.