SNRPB2: Difference between revisions

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{{Infobox_gene}}
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'''U2 small nuclear ribonucleoprotein B''''' is a [[protein]] that in humans is encoded by the ''SNRPB2'' [[gene]].<ref name="pmid2951739">{{cite journal | vauthors = Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ | title = Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen | journal = Proc Natl Acad Sci U S A | volume = 84 | issue = 8 | pages = 2421–5 |date=May 1987 | pmid = 2951739 | pmc = 304663 | doi =10.1073/pnas.84.8.2421 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B''| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6629| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SNRPB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a9n.
| PDB = {{PDB2|1a9n}}
| Name = Small nuclear ribonucleoprotein polypeptide B''
| HGNCid = 11155
| Symbol = SNRPB2
| AltSymbols =; MGC24807; MGC45309
| OMIM = 603520
| ECnumber = 
| Homologene = 37728
| MGIid = 104805
| GeneAtlas_image1 = PBB_GE_SNRPB2_202505_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005686 |text = snRNP U2}}
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6629
    | Hs_Ensembl = ENSG00000125870
    | Hs_RefseqProtein = NP_003083
    | Hs_RefseqmRNA = NM_003092
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 16658629
    | Hs_GenLoc_end = 16670421
    | Hs_Uniprot = P08579
    | Mm_EntrezGene = 20639
    | Mm_Ensembl = ENSMUSG00000008333
    | Mm_RefseqmRNA = NM_021335
    | Mm_RefseqProtein = NP_067310
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 142754501
    | Mm_GenLoc_end = 142764294
    | Mm_Uniprot = Q62378
  }}
}}
'''Small nuclear ribonucleoprotein polypeptide B''''', also known as '''SNRPB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B''| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6629| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| summary_text = The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B''| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6629| accessdate = }}</ref>
| summary_text = The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B''| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6629| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Feeney RJ, Zieve GW |title=Nuclear exchange of the U1 and U2 snRNP-specific proteins. |journal=J. Cell Biol. |volume=110 |issue= 4 |pages= 871-81 |year= 1990 |pmid= 2139037 |doi= }}
*{{cite journal  | vauthors=Feeney RJ, Zieve GW |title=Nuclear exchange of the U1 and U2 snRNP-specific proteins. |journal=J. Cell Biol. |volume=110 |issue= 4 |pages= 871–81 |year= 1990 |pmid= 2139037 |doi=10.1083/jcb.110.4.871  | pmc=2116108 }}
*{{cite journal  | author=Habets WJ, Sillekens PT, Hoet MH, ''et al.'' |title=Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 8 |pages= 2421-5 |year= 1987 |pmid= 2951739 |doi=  }}
*{{cite journal  | vauthors=Laitinen J, Saris P, Hölttä E, Pettersson I |title=U2-snRNP B" protein gene is an early growth-inducible gene. |journal=J. Cell. Biochem. |volume=58 |issue= 4 |pages= 490–8 |year= 1995 |pmid= 7593271 |doi= 10.1002/jcb.240580412 }}
*{{cite journal  | author=Laitinen J, Saris P, Hölttä E, Pettersson I |title=U2-snRNP B" protein gene is an early growth-inducible gene. |journal=J. Cell. Biochem. |volume=58 |issue= 4 |pages= 490-8 |year= 1995 |pmid= 7593271 |doi= 10.1002/jcb.240580412 }}
*{{cite journal   |vauthors=Hong W, Bennett M, Xiao Y, etal |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354–61 |year= 1997 |pmid= 9016565 |doi=10.1093/nar/25.2.354  | pmc=146436 }}
*{{cite journal | author=Hong W, Bennett M, Xiao Y, ''et al.'' |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354-61 |year= 1997 |pmid= 9016565 |doi=  }}
*{{cite journal  | vauthors=Liu Q, Fischer U, Wang F, Dreyfuss G |title=The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. |journal=Cell |volume=90 |issue= 6 |pages= 1013–21 |year= 1997 |pmid= 9323129 |doi=10.1016/S0092-8674(00)80367-0 }}
*{{cite journal  | author=Liu Q, Fischer U, Wang F, Dreyfuss G |title=The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. |journal=Cell |volume=90 |issue= 6 |pages= 1013-21 |year= 1997 |pmid= 9323129 |doi=  }}
*{{cite journal  | vauthors=Moraitou M, Patrinou-Georgoula M, Guialis A |title=Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. |journal=Biochem. J. |volume=332 |issue=  1|pages= 135–44 |year= 1998 |pmid= 9576861 |doi= | pmc=1219461 }}
*{{cite journal  | author=Moraitou M, Patrinou-Georgoula M, Guialis A |title=Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. |journal=Biochem. J. |volume=332 ( Pt 1) |issue=  |pages= 135-44 |year= 1998 |pmid= 9576861 |doi=  }}
*{{cite journal  | vauthors=Price SR, Evans PR, Nagai K |title=Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. |journal=Nature |volume=394 |issue= 6694 |pages= 645–50 |year= 1998 |pmid= 9716128 |doi= 10.1038/29234 }}
*{{cite journal  | author=Price SR, Evans PR, Nagai K |title=Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. |journal=Nature |volume=394 |issue= 6694 |pages= 645-50 |year= 1998 |pmid= 9716128 |doi= 10.1038/29234 }}
*{{cite journal   |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
*{{cite journal | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
*{{cite journal  | vauthors=Bühler D, Raker V, Lührmann R, Fischer U |title=Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 13 |pages= 2351–7 |year= 2000 |pmid= 10556282 |doi=10.1093/hmg/8.13.2351 }}
*{{cite journal  | author=Bühler D, Raker V, Lührmann R, Fischer U |title=Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 13 |pages= 2351-7 |year= 2000 |pmid= 10556282 |doi=  }}
*{{cite journal   |vauthors=Pellizzoni L, Charroux B, Rappsilber J, etal |title=A functional interaction between the survival motor neuron complex and RNA polymerase II. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 75–85 |year= 2001 |pmid= 11149922 |doi=10.1083/jcb.152.1.75  | pmc=2193649 }}
*{{cite journal | author=Pellizzoni L, Charroux B, Rappsilber J, ''et al.'' |title=A functional interaction between the survival motor neuron complex and RNA polymerase II. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 75-85 |year= 2001 |pmid= 11149922 |doi=  }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation. |journal=Nature |volume=414 |issue= 6866 |pages= 929–33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }}
*{{cite journal  | author=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation. |journal=Nature |volume=414 |issue= 6866 |pages= 929-33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal   |vauthors=Chung S, Zhou Z, Huddleston KA, etal |title=Crooked neck is a component of the human spliceosome and implicated in the splicing process. |journal=Biochim. Biophys. Acta |volume=1576 |issue= 3 |pages= 287–97 |year= 2002 |pmid= 12084575 |doi=  10.1016/S0167-4781(02)00368-8}}
*{{cite journal | author=Chung S, Zhou Z, Huddleston KA, ''et al.'' |title=Crooked neck is a component of the human spliceosome and implicated in the splicing process. |journal=Biochim. Biophys. Acta |volume=1576 |issue= 3 |pages= 287-97 |year= 2002 |pmid= 12084575 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6629}}
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{{Ribonucleoproteins}}


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Revision as of 06:46, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[1][2]

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[2]

References

  1. ↑ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739.
  2. ↑ 2.0 2.1 "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Further reading



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