SLC39A6
| Solute carrier family 39 (zinc transporter), member 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SLC39A6 ; LIV-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8199 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC39A6 202088 at tn.png | |||||||||||
| File:PBB GE SLC39A6 202089 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 39 (zinc transporter), member 6, also known as SLC39A6, is a human gene.[1]
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM][1]
See also
References
Further reading
- Taylor KM, Nicholson RI (2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim. Biophys. Acta. 1611 (1–2): 16–30. PMID 12659941.
- Manning DL, Daly RJ, Lord PG; et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. PMID 2903103.
- Dressman MA, Walz TM, Lavedan C; et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies". Pharmacogenomics J. 1 (2): 135–41. PMID 11911440.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Taylor KM, Morgan HE, Johnson A; et al. (2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem. J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMID 12839489.
- Schaner ME, Ross DT, Ciaravino G; et al. (2004). "Gene expression patterns in ovarian carcinomas". Mol. Biol. Cell. 14 (11): 4376–86. doi:10.1091/mbc.E03-05-0279. PMID 12960427.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Kasper G, Weiser AA, Rump A; et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients". Int. J. Cancer. 117 (6): 961–73. doi:10.1002/ijc.21235. PMID 15986450.
- Zhao L, Chen W, Taylor KM; et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway". Biochem. Biophys. Res. Commun. 363 (1): 82–8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.
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