SLC1A5: Difference between revisions

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{{Infobox_gene}}
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'''Neutral amino acid transporter B(0)''' is a [[protein]] that in humans is encoded by the ''SLC1A5'' [[gene]].<ref name="pmid8702519">{{cite journal | vauthors = Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V | title = Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line | journal = The Journal of Biological Chemistry | volume = 271 | issue = 31 | pages = 18657–61 | date = August 1996 | pmid = 8702519 | pmc =  | doi = 10.1074/jbc.271.31.18657 }}</ref><ref name="pmid10051606">{{cite journal | vauthors = Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD | title = The RD114/simian type D retrovirus receptor is a neutral amino acid transporter | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 2129–34 | date = March 1999 | pmid = 10051606 | pmc = 26748 | doi = 10.1073/pnas.96.5.2129 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6510| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 1 (neutral amino acid transporter), member 5
| HGNCid = 10943
| Symbol = SLC1A5
| AltSymbols =; AAAT; ASCT2; ATBO; FLJ31068; M7V1; M7VS1; R16; RDRC
| OMIM = 109190
| ECnumber = 
| Homologene = 21155
| MGIid = 105305
| GeneAtlas_image1 = PBB_GE_SLC1A5_208916_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0015175 |text = neutral amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0017153 |text = sodium:dicarboxylate symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}} {{GNF_GO|id=GO:0015804 |text = neutral amino acid transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6510
    | Hs_Ensembl = ENSG00000105281
    | Hs_RefseqProtein = NP_005619
    | Hs_RefseqmRNA = NM_005628
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 51969982
    | Hs_GenLoc_end = 51983062
    | Hs_Uniprot = Q15758
    | Mm_EntrezGene = 20514
    | Mm_Ensembl = ENSMUSG00000001918
    | Mm_RefseqmRNA = NM_009201
    | Mm_RefseqProtein = NP_033227
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 15939891
    | Mm_GenLoc_end = 15956764
    | Mm_Uniprot = Q3UFR4
  }}
}}
'''Solute carrier family 1 (neutral amino acid transporter), member 5''', also known as '''SLC1A5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6510| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}
 
==See also==
* [[Glutamate transporter]]
* [[Glutamate transporter]]
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tailor CS, Nouri A, Zhao Y, Takeuchi Y, Kabat D | title = A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses | journal = Journal of Virology | volume = 73 | issue = 5 | pages = 4470–4 | date = May 1999 | pmid = 10196349 | pmc = 104338 | doi =  }}
| citations =
* {{cite journal | vauthors = Tailor CS, Marin M, Nouri A, Kavanaugh MP, Kabat D | title = Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons | journal = The Journal of Biological Chemistry | volume = 276 | issue = 29 | pages = 27221–30 | date = July 2001 | pmid = 11350958 | doi = 10.1074/jbc.M100737200 }}
*{{cite journal | author=Kekuda R, Prasad PD, Fei YJ, ''et al.'' |title=Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18657-61 |year= 1996 |pmid= 8702519 |doi=  }}
* {{cite journal | vauthors = Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset FL, Kabat D | title = The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors | journal = Journal of Virology | volume = 76 | issue = 13 | pages = 6442–52 | date = July 2002 | pmid = 12050356 | pmc = 136247 | doi = 10.1128/JVI.76.13.6442-6452.2002 }}
*{{cite journal | author=Rasko JE, Battini JL, Gottschalk RJ, ''et al.'' |title=The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 2129-34 |year= 1999 |pmid= 10051606 |doi= }}
* {{cite journal | vauthors = Kudo Y, Boyd CA | title = Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization | journal = Placenta | volume = 23 | issue = 7 | pages = 536–41 | date = August 2002 | pmid = 12175968 | doi = 10.1053/plac.2002.0839 }}
*{{cite journal | author=Tailor CS, Nouri A, Zhao Y, ''et al.'' |title=A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. |journal=J. Virol. |volume=73 |issue= 5 |pages= 4470-4 |year= 1999 |pmid= 10196349 |doi= }}
* {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = December 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
*{{cite journal | author=Tailor CS, Marin M, Nouri A, ''et al.'' |title=Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27221-30 |year= 2001 |pmid= 11350958 |doi= 10.1074/jbc.M100737200 }}
* {{cite journal | vauthors = Potter SJ, Lu A, Wilcken B, Green K, Rasko JE | title = Hartnup disorder: polymorphisms identified in the neutral amino acid transporter SLC1A5 | journal = Journal of Inherited Metabolic Disease | volume = 25 | issue = 6 | pages = 437–48 | date = October 2002 | pmid = 12555937 | doi = 10.1023/A:1021286714582 }}
*{{cite journal | author=Lavillette D, Marin M, Ruggieri A, ''et al.'' |title=The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. |journal=J. Virol. |volume=76 |issue= 13 |pages= 6442-52 |year= 2002 |pmid= 12050356 |doi=  }}
* {{cite journal | vauthors = Marin M, Lavillette D, Kelly SM, Kabat D | title = N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions | journal = Journal of Virology | volume = 77 | issue = 5 | pages = 2936–45 | date = March 2003 | pmid = 12584318 | pmc = 149750 | doi = 10.1128/JVI.77.5.2936-2945.2003 }}
*{{cite journal  | author=Kudo Y, Boyd CA |title=Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. |journal=Placenta |volume=23 |issue= 7 |pages= 536-41 |year= 2003 |pmid= 12175968 |doi=  }}
* {{cite journal | vauthors = Kudo Y, Boyd CA, Sargent IL, Redman CW | title = Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia | journal = Biochimica et Biophysica Acta | volume = 1638 | issue = 1 | pages = 63–71 | date = May 2003 | pmid = 12757936 | doi = 10.1016/s0925-4439(03)00043-7 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Knerr I, Weigel C, Linnemann K, Dötsch J, Meissner U, Fusch C, Rascher W | title = Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons | journal = American Journal of Obstetrics and Gynecology | volume = 189 | issue = 2 | pages = 583–8 | date = August 2003 | pmid = 14520239 | doi = 10.1067/S0002-9378(03)00538-6 }}
*{{cite journal | author=Potter SJ, Lu A, Wilcken B, ''et al.'' |title=Hartnup disorder: polymorphisms identified in the neutral amino acid transporter SLC1A5. |journal=J. Inherit. Metab. Dis. |volume=25 |issue= 6 |pages= 437-48 |year= 2003 |pmid= 12555937 |doi= }}
* {{cite journal | vauthors = Palmada M, Speil A, Jeyaraj S, Böhmer C, Lang F | title = The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2 | journal = Biochemical and Biophysical Research Communications | volume = 331 | issue = 1 | pages = 272–7 | date = May 2005 | pmid = 15845389 | doi = 10.1016/j.bbrc.2005.03.159 }}
*{{cite journal | author=Marin M, Lavillette D, Kelly SM, Kabat D |title=N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. |journal=J. Virol. |volume=77 |issue= 5 |pages= 2936-45 |year= 2003 |pmid= 12584318 |doi= }}
* {{cite journal | vauthors = Uchiyama T, Matsuda Y, Wada M, Takahashi S, Fujita T | title = Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells | journal = FEBS Letters | volume = 579 | issue = 11 | pages = 2499–506 | date = April 2005 | pmid = 15848195 | doi = 10.1016/j.febslet.2005.03.065 }}
*{{cite journal | author=Kudo Y, Boyd CA, Sargent IL, Redman CW |title=Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. |journal=Biochim. Biophys. Acta |volume=1638 |issue= 1 |pages= 63-71 |year= 2003 |pmid= 12757936 |doi= }}
* {{cite journal | vauthors = Bungard CI, McGivan JD | title = Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers | journal = Archives of Biochemistry and Biophysics | volume = 443 | issue = 1-2 | pages = 53–9 | date = November 2005 | pmid = 16197915 | doi = 10.1016/j.abb.2005.08.016 }}
*{{cite journal | author=Knerr I, Weigel C, Linnemann K, ''et al.'' |title=Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons. |journal=Am. J. Obstet. Gynecol. |volume=189 |issue= 2 |pages= 583-8 |year= 2003 |pmid= 14520239 |doi= }}
* {{cite journal | vauthors = Brauers E, Vester U, Zerres K, Eggermann T | title = Search for mutations in SLC1A5 (19q13) in cystinuria patients | journal = Journal of Inherited Metabolic Disease | volume = 28 | issue = 6 | pages = 1169–71 | year = 2006 | pmid = 16435221 | doi = 10.1007/s10545-005-0094-x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Gegelashvili M, Rodriguez-Kern A, Pirozhkova I, Zhang J, Sung L, Gegelashvili G | title = High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes | journal = Neurochemistry International | volume = 48 | issue = 6-7 | pages = 611–5 | year = 2006 | pmid = 16516348 | doi = 10.1016/j.neuint.2005.12.033 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Cheynet V, Oriol G, Mallet F | title = Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein | journal = Retrovirology | volume = 3 | issue = | pages = 41 | date = July 2006 | pmid = 16820059 | pmc = 1524976 | doi = 10.1186/1742-4690-3-41 }}
*{{cite journal | author=Palmada M, Speil A, Jeyaraj S, ''et al.'' |title=The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 1 |pages= 272-7 |year= 2005 |pmid= 15845389 |doi= 10.1016/j.bbrc.2005.03.159 }}
* {{cite journal | vauthors = Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF | title = Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes | journal = Journal of Proteome Research | volume = 5 | issue = 11 | pages = 3135–44 | date = November 2006 | pmid = 17081065 | doi = 10.1021/pr060363j }}
*{{cite journal | author=Uchiyama T, Matsuda Y, Wada M, ''et al.'' |title=Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. |journal=FEBS Lett. |volume=579 |issue= 11 |pages= 2499-506 |year= 2005 |pmid= 15848195 |doi= 10.1016/j.febslet.2005.03.065 }}
*{{cite journal | author=Bungard CI, McGivan JD |title=Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. |journal=Arch. Biochem. Biophys. |volume=443 |issue= 1-2 |pages= 53-9 |year= 2006 |pmid= 16197915 |doi= 10.1016/j.abb.2005.08.016 }}
*{{cite journal | author=Brauers E, Vester U, Zerres K, Eggermann T |title=Search for mutations in SLC1A5 (19q13) in cystinuria patients. |journal=J. Inherit. Metab. Dis. |volume=28 |issue= 6 |pages= 1169-71 |year= 2006 |pmid= 16435221 |doi= 10.1007/s10545-005-0094-x }}
*{{cite journal | author=Gegelashvili M, Rodriguez-Kern A, Pirozhkova I, ''et al.'' |title=High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. |journal=Neurochem. Int. |volume=48 |issue= 6-7 |pages= 611-5 |year= 2006 |pmid= 16516348 |doi= 10.1016/j.neuint.2005.12.033 }}
*{{cite journal  | author=Cheynet V, Oriol G, Mallet F |title=Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein. |journal=Retrovirology |volume=3 |issue=  |pages= 41 |year= 2006 |pmid= 16820059 |doi= 10.1186/1742-4690-3-41 }}
*{{cite journal  | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins|bg|bg0}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Latest revision as of 06:27, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.[1][2][3]

See also

References

  1. ↑ Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V (August 1996). "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line". The Journal of Biological Chemistry. 271 (31): 18657–61. doi:10.1074/jbc.271.31.18657. PMID 8702519.
  2. ↑ Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD (March 1999). "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2129–34. doi:10.1073/pnas.96.5.2129. PMC 26748. PMID 10051606.
  3. ↑ "Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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