View source for SF3B3

{{Infobox_gene}}
'''Splicing factor 3B subunit 3''' is a [[protein]] that in humans is encoded by the ''SF3B3'' [[gene]].<ref name="pmid10490618">{{cite journal |author1=Das BK |author2=Xia L |author3=Palandjian L |author4=Gozani O |author5=Chyung Y |author6=Reed R | title = Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155 | journal = Mol Cell Biol | volume = 19 | issue = 10 | pages = 6796–802 |date=February 2000 | pmid = 10490618 | pmc = 84676 | doi =  10.1128/mcb.19.10.6796}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23450| accessdate = }}</ref>

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{{PBB_Summary
| section_title =
| summary_text = This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.<ref name="entrez" />
}}

==Interactions==
SF3B3 has been shown to [[Protein-protein interaction|interact]] with [[SF3B1]],<ref name=pmid10490618 /><ref name=pmid12234937>{{cite journal |last=Will |first=Cindy L |authorlink= |author2=Urlaub Henning |author3=Achsel Tilmann |author4=Gentzel Marc |author5=Wilm Matthias |author6=Lührmann Reinhard  |date=September 2002 |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein |journal=EMBO J. |volume=21 |issue=18 |pages=4978–88 |publisher= |location = England| issn = 0261-4189| pmid = 12234937 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/emboj/cdf480 |pmc=126279 }}</ref> [[Transcription initiation protein SPT3 homolog]]<ref name=pmid11564863>{{cite journal |last=Martinez |first=E |authorlink= |author2=Palhan V B |author3=Tjernberg A |author4=Lymar E S |author5=Gamper A M |author6=Kundu T K |author7=Chait B T |author8=Roeder R G  |date=October 2001 |title=Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6782–95 |publisher= |location = United States| issn = 0270-7306| pmid = 11564863 |doi = 10.1128/MCB.21.20.6782-6795.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99856 }}</ref> and [[TAF9]].<ref name=pmid11564863/>

==References==
{{Reflist}}

==Further reading==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27  }}
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47  }}
*{{cite journal  |author1=Bonaldo MF |author2=Lennon G |author3=Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal   |vauthors=Mintz PJ, Patterson SD, Neuwald AF, etal |title=Purification and biochemical characterization of interchromatin granule clusters |journal=EMBO J. |volume=18 |issue= 15 |pages= 4308–20 |year= 1999 |pmid= 10428969 |doi= 10.1093/emboj/18.15.4308  | pmc=1171507 }}
*{{cite journal   |vauthors=Brand M, Moggs JG, Oulad-Abdelghani M, etal |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187  | pmc=150203 }}
*{{cite journal   |vauthors=Gangloff YG, Pointud JC, Thuault S, etal |title=The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5109–21 |year= 2001 |pmid= 11438666 |doi= 10.1128/MCB.21.15.5109-5121.2001  | pmc=87236 }}
*{{cite journal   |vauthors=Will CL, Schneider C, MacMillan AM, etal |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536  | pmc=125580 }}
*{{cite journal   |vauthors=Martinez E, Palhan VB, Tjernberg A, etal |title=Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001  | pmc=99856 }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266  }}
*{{cite journal   |vauthors=Scott MP, Zappacosta F, Kim EY, etal |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 }}
*{{cite journal   |vauthors=Will CL, Urlaub H, Achsel T, etal |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=10.1093/emboj/cdf480  | pmc=126279  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |author1=Cavusoglu N |author2=Brand M |author3=Tora L |author4=Van Dorsselaer A |title=Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis |journal=Proteomics |volume=3 |issue= 2 |pages= 217–23 |year= 2003 |pmid= 12601814 |doi= 10.1002/pmic.200390030 }}
*{{cite journal   |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Will CL, Schneider C, Hossbach M, etal |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=10.1261/rna.7320604  | pmc=1370585  }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
}}
{{Refend}}

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{{Gene-16-stub}}