SATB1

SATB homeobox 1
File:PBB Protein SATB1 image.jpg PDB rendering based on 1yse.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yse​
Identifiers
Symbols	SATB1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2232
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SATB1 203408 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SATB homeobox 1, also known as SATB1, is a human gene.

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFNgamma treatment on chromatin loop architecture of the MHC class-I locus and altered expression of genes within the locus.

Further reading

• Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T (1992). "A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition". Cell. 70 (4): 631–45. PMID 1505028.CS1 maint: Multiple names: authors list (link)
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T (1994). "A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1". Mol. Cell. Biol. 14 (3): 1852–60. PMID 8114718.CS1 maint: Multiple names: authors list (link)
• Xu L, Deng HX, Xia JH; et al. (1997). "Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization". Cytogenet. Cell Genet. 77 (3–4): 205–6. PMID 9284917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.CS1 maint: Multiple names: authors list (link)
• Escalier D, Allenet B, Badrichani A, Garchon HJ (1999). "High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein". J. Immunol. 162 (1): 292–8. PMID 9886398.CS1 maint: Multiple names: authors list (link)
• Liu J, Barnett A, Neufeld EJ, Dudley JP (1999). "Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation". Mol. Cell. Biol. 19 (7): 4918–26. PMID 10373541.CS1 maint: Multiple names: authors list (link)
• Galande S, Dickinson LA, Mian IS; et al. (2001). "SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis". Mol. Cell. Biol. 21 (16): 5591–604. doi:10.1128/MCB.21.16.5591-5604.2001. PMID 11463840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kieffer LJ, Greally JM, Landres I; et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3". J. Immunol. 168 (8): 3915–22. PMID 11937547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durrin LK, Krontiris TG (2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics. 79 (6): 809–17. doi:10.1006/geno.2002.6772. PMID 12036295.
• Yasui D, Miyano M, Cai S; et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cai S, Han HJ, Kohwi-Shigematsu T (2003). "Tissue-specific nuclear architecture and gene expression regulated by SATB1". Nat. Genet. 34 (1): 42–51. doi:10.1038/ng1146. PMID 12692553.CS1 maint: Multiple names: authors list (link)
• Fujii Y, Kumatori A, Nakamura M (2004). "SATB1 makes a complex with p300 and represses gp91(phox) promoter activity". Microbiol. Immunol. 47 (10): 803–11. PMID 14605447.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.CS1 maint: Multiple names: authors list (link)
• Wen J, Huang S, Rogers H; et al. (2005). "SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression". Blood. 105 (8): 3330–9. doi:10.1182/blood-2004-08-2988. PMID 15618465.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seo J, Lozano MM, Dudley JP (2005). "Nuclear matrix binding regulates SATB1-mediated transcriptional repression". J. Biol. Chem. 280 (26): 24600–9. doi:10.1074/jbc.M414076200. PMID 15851481.CS1 maint: Multiple names: authors list (link)
• Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T (2006). "A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage". Cell Cycle. 4 (8): 1099–106. PMID 15970696.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)