S100P: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''[[S100 protein|S100]] calcium-binding protein P''' ('''S100P''') is a [[protein]] that in humans is encoded by the ''S100P'' [[gene]].<ref name="pmid8341667">{{cite journal | vauthors = Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 14 | pages = 6547–51 | date = Aug 1993 | pmid = 8341667 | pmc = 46969 | doi = 10.1073/pnas.90.14.6547 }}</ref><ref name="pmid7759097">{{cite journal | vauthors = Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW | title = Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family | journal = Genomics | volume = 25 | issue = 3 | pages = 638–43 | date = Jun 1995 | pmid = 7759097 | pmc =  | doi = 10.1016/0888-7543(95)80005-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: S100P S100 calcium binding protein P| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6286| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_S100P_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1j55.
| PDB = {{PDB2|1j55}}, {{PDB2|1ozo}}
| Name = S100 calcium binding protein P
| HGNCid = 10504
| Symbol = S100P
| AltSymbols =; MIG9
| OMIM = 600614
| ECnumber = 
| Homologene = 81743
| MGIid = 
| GeneAtlas_image1 = PBB_GE_S100P_204351_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0043542 |text = endothelial cell migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6286
    | Hs_Ensembl = ENSG00000163993
    | Hs_RefseqProtein = NP_005971
    | Hs_RefseqmRNA = NM_005980
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 6745697
    | Hs_GenLoc_end = 6749797
    | Hs_Uniprot = P25815
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''S100 calcium binding protein P''', also known as '''S100P''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100P S100 calcium binding protein P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6286| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[S-100 protein|S100 family of proteins]] containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca<sup>2+</sup>, also binds Zn<sup>2+</sup> and Mg<sup>2+</sup>. This protein may play a role in the etiology of prostate cancer.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.<ref name="entrez">{{cite web | title = Entrez Gene: S100P S100 calcium binding protein P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6286| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
S100P has been shown to [[Protein-protein interaction|interact]] with [[ezrin|EZR]] <ref name="pmid12808036">{{cite journal | vauthors = Koltzscher M, Neumann C, König S, Gerke V | title = Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P | journal = Molecular Biology of the Cell | volume = 14 | issue = 6 | pages = 2372–84 | date = Jun 2003 | pmid = 12808036 | pmc = 194886 | doi = 10.1091/mbc.E02-09-0553 }}</ref> and RAGE.<ref name="pmid25084534">{{cite journal | vauthors = Penumutchu SR, Chou RH, Yu C | title = Structural insights into calcium-bound S100P and the V domain of the RAGE complex | journal = PLOS ONE | volume = 9 | issue = 8 | pages = e103947 | date = 2014-08-01 | pmid = 25084534 | pmc = 4118983 | doi = 10.1371/journal.pone.0103947 }}</ref> The interactions between S100P and RAGE are disrupted by  cromolyn<ref>{{cite journal | vauthors = Penumutchu SR, Chou RH, Yu C | title = Interaction between S100P and the anti-allergy drug cromolyn | journal = Biochemical and Biophysical Research Communications | volume = 454 | issue = 3 | pages = 404–409 | date = Oct 2014 | pmid = 25450399 | doi = 10.1016/j.bbrc.2014.10.048 }}</ref> and pentamidine.<ref name="pmid25084534"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schäfer BW, Heizmann CW | title = The S100 family of EF-hand calcium-binding proteins: functions and pathology. | journal = Trends Biochem. Sci. | volume = 21 | issue = 4 | pages = 134–40 | year = 1996 | pmid = 8701470 | doi = 10.1016/S0968-0004(96)80167-8 }}
| citations =
* {{cite journal | vauthors = Emoto Y, Kobayashi R, Akatsuka H, Hidaka H | title = Purification and characterization of a new member of the S-100 protein family from human placenta. | journal = Biochem. Biophys. Res. Commun. | volume = 182 | issue = 3 | pages = 1246–53 | year = 1992 | pmid = 1540168 | doi = 10.1016/0006-291X(92)91865-N }}
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
* {{cite journal | vauthors = Becker T, Gerke V, Kube E, Weber K | title = S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. | journal = Eur. J. Biochem. | volume = 207 | issue = 2 | pages = 541–7 | year = 1992 | pmid = 1633809 | doi = 10.1111/j.1432-1033.1992.tb17080.x }}
*{{cite journal | author=Emoto Y, Kobayashi R, Akatsuka H, Hidaka H |title=Purification and characterization of a new member of the S-100 protein family from human placenta. |journal=Biochem. Biophys. Res. Commun. |volume=182 |issue= 3 |pages= 1246-53 |year= 1992 |pmid= 1540168 |doi= }}
* {{cite journal | vauthors = Gribenko AV, Makhatadze GI | title = Oligomerization and divalent ion binding properties of the S100P protein: a Ca2+/Mg2+-switch model. | journal = J. Mol. Biol. | volume = 283 | issue = 3 | pages = 679–94 | year = 1998 | pmid = 9784376 | doi = 10.1006/jmbi.1998.2116 }}
*{{cite journal | author=Becker T, Gerke V, Kube E, Weber K |title=S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. |journal=Eur. J. Biochem. |volume=207 |issue= 2 |pages= 541-7 |year= 1992 |pmid= 1633809 |doi= }}
* {{cite journal | vauthors = Koltzscher M, Gerke V | title = Identification of hydrophobic amino acid residues involved in the formation of S100P homodimers in vivo. | journal = Biochemistry | volume = 39 | issue = 31 | pages = 9533–9 | year = 2000 | pmid = 10924150 | doi = 10.1021/bi000257 }}
*{{cite journal  | author=Schäfer BW, Wicki R, Engelkamp D, ''et al.'' |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638-43 |year= 1995 |pmid= 7759097 |doi=  }}
* {{cite journal | vauthors = Harvell JD, Fulton R, Jones CD, Terris DJ, Warnke RA | title = Composite dendritic cell neoplasm (NOS) and small lymphocytic lymphoma. | journal = Appl. Immunohistochem. Mol. Morphol. | volume = 8 | issue = 4 | pages = 322–8 | year = 2001 | pmid = 11127925 | doi = 10.1097/00022744-200012000-00010 }}
*{{cite journal  | author=Engelkamp D, Schäfer BW, Mattei MG, ''et al.'' |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547-51 |year= 1993 |pmid= 8341667 |doi=  }}
* {{cite journal | vauthors = Gribenko AV, Hopper JE, Makhatadze GI | title = Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. | journal = Biochemistry | volume = 40 | issue = 51 | pages = 15538–48 | year = 2002 | pmid = 11747429 | doi = 10.1021/bi0114731 }}
*{{cite journal | author=Gribenko AV, Makhatadze GI |title=Oligomerization and divalent ion binding properties of the S100P protein: a Ca2+/Mg2+-switch model. |journal=J. Mol. Biol. |volume=283 |issue= 3 |pages= 679-94 |year= 1998 |pmid= 9784376 |doi= 10.1006/jmbi.1998.2116 }}
* {{cite journal | vauthors = Gribenko AV, Guzmán-Casado M, Lopez MM, Makhatadze GI | title = Conformational and thermodynamic properties of peptide binding to the human S100P protein. | journal = Protein Sci. | volume = 11 | issue = 6 | pages = 1367–75 | year = 2003 | pmid = 12021435 | pmc = 2373636 | doi = 10.1110/ps.0202202 }}
*{{cite journal | author=Koltzscher M, Gerke V |title=Identification of hydrophobic amino acid residues involved in the formation of S100P homodimers in vivo. |journal=Biochemistry |volume=39 |issue= 31 |pages= 9533-9 |year= 2000 |pmid= 10924150 |doi= }}
* {{cite journal | vauthors = Filipek A, Jastrzebska B, Nowotny M, Kuznicki J | title = CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 28848–52 | year = 2002 | pmid = 12042313 | doi = 10.1074/jbc.M203602200 }}
*{{cite journal | author=Harvell JD, Fulton R, Jones CD, ''et al.'' |title=Composite dendritic cell neoplasm (NOS) and small lymphocytic lymphoma. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=8 |issue= 4 |pages= 322-8 |year= 2001 |pmid= 11127925 |doi= }}
* {{cite journal | vauthors = Zhang H, Wang G, Ding Y, Wang Z, Barraclough R, Rudland PS, Fernig DG, Rao Z | title = The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. | journal = J. Mol. Biol. | volume = 325 | issue = 4 | pages = 785–94 | year = 2003 | pmid = 12507480 | doi = 10.1016/S0022-2836(02)01278-0 }}
*{{cite journal | author=Gribenko AV, Hopper JE, Makhatadze GI |title=Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. |journal=Biochemistry |volume=40 |issue= 51 |pages= 15538-48 |year= 2002 |pmid= 11747429 |doi= }}
* {{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 26923–8 | year = 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 }}
*{{cite journal | author=Gribenko AV, Guzmán-Casado M, Lopez MM, Makhatadze GI |title=Conformational and thermodynamic properties of peptide binding to the human S100P protein. |journal=Protein Sci. |volume=11 |issue= 6 |pages= 1367-75 |year= 2003 |pmid= 12021435 |doi= }}
* {{cite journal | vauthors = Koltzscher M, Neumann C, König S, Gerke V | title = Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. | journal = Mol. Biol. Cell | volume = 14 | issue = 6 | pages = 2372–84 | year = 2004 | pmid = 12808036 | pmc = 194886 | doi = 10.1091/mbc.E02-09-0553 }}
*{{cite journal | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848-52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
* {{cite journal | vauthors = Arumugam T, Simeone DM, Schmidt AM, Logsdon CD | title = S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5059–65 | year = 2004 | pmid = 14617629 | doi = 10.1074/jbc.M310124200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jin G, Wang S, Hu X, Jing Z, Chen J, Ying K, Xie Y, Mao Y | title = Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. | journal = Mol. Biol. Rep. | volume = 30 | issue = 4 | pages = 243–8 | year = 2004 | pmid = 14672411 | doi = 10.1023/A:1026311423326 }}
*{{cite journal  | author=Zhang H, Wang G, Ding Y, ''et al.'' |title=The crystal structure at 2A resolution of the Ca2+ -binding protein S100P. |journal=J. Mol. Biol. |volume=325 |issue= 4 |pages= 785-94 |year= 2003 |pmid= 12507480 |doi= }}
* {{cite journal | vauthors = Sato N, Fukushima N, Matsubayashi H, Goggins M | title = Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. | journal = Oncogene | volume = 23 | issue = 8 | pages = 1531–8 | year = 2004 | pmid = 14716296 | doi = 10.1038/sj.onc.1207269 }}
*{{cite journal | author=Nowotny M, Spiechowicz M, Jastrzebska B, ''et al.'' |title=Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26923-8 |year= 2003 |pmid= 12746458 |doi= 10.1074/jbc.M211518200 }}
* {{cite journal | vauthors = Lee YC, Volk DE, Thiviyanathan V, Kleerekoper Q, Gribenko AV, Zhang S, Gorenstein DG, Makhatadze GI, Luxon BA | title = NMR structure of the Apo-S100P protein. | journal = J. Biomol. NMR | volume = 29 | issue = 3 | pages = 399–402 | year = 2005 | pmid = 15213440 | doi = 10.1023/B:JNMR.0000032617.88899.4b }}
*{{cite journal | author=Koltzscher M, Neumann C, König S, Gerke V |title=Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. |journal=Mol. Biol. Cell |volume=14 |issue= 6 |pages= 2372-84 |year= 2004 |pmid= 12808036 |doi= 10.1091/mbc.E02-09-0553 }}
*{{cite journal | author=Arumugam T, Simeone DM, Schmidt AM, Logsdon CD |title=S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5059-65 |year= 2004 |pmid= 14617629 |doi= 10.1074/jbc.M310124200 }}
*{{cite journal | author=Jin G, Wang S, Hu X, ''et al.'' |title=Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. |journal=Mol. Biol. Rep. |volume=30 |issue= 4 |pages= 243-8 |year= 2004 |pmid= 14672411 |doi= }}
*{{cite journal | author=Sato N, Fukushima N, Matsubayashi H, Goggins M |title=Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. |journal=Oncogene |volume=23 |issue= 8 |pages= 1531-8 |year= 2004 |pmid= 14716296 |doi= 10.1038/sj.onc.1207269 }}
*{{cite journal | author=Lee YC, Volk DE, Thiviyanathan V, ''et al.'' |title=NMR structure of the Apo-S100P protein. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 399-402 |year= 2005 |pmid= 15213440 |doi= 10.1023/B:JNMR.0000032617.88899.4b }}
}}
{{refend}}
{{refend}}


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[[Category:S100 proteins]]

Latest revision as of 01:58, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene.[1][2][3]

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.[3]

Interactions

S100P has been shown to interact with EZR [4] and RAGE.[5] The interactions between S100P and RAGE are disrupted by cromolyn[6] and pentamidine.[5]

References

  1. ↑ Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  2. ↑ Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Jun 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
  3. ↑ 3.0 3.1 "Entrez Gene: S100P S100 calcium binding protein P".
  4. ↑ Koltzscher M, Neumann C, König S, Gerke V (Jun 2003). "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P". Molecular Biology of the Cell. 14 (6): 2372–84. doi:10.1091/mbc.E02-09-0553. PMC 194886. PMID 12808036.
  5. ↑ 5.0 5.1 Penumutchu SR, Chou RH, Yu C (2014-08-01). "Structural insights into calcium-bound S100P and the V domain of the RAGE complex". PLOS ONE. 9 (8): e103947. doi:10.1371/journal.pone.0103947. PMC 4118983. PMID 25084534.
  6. ↑ Penumutchu SR, Chou RH, Yu C (Oct 2014). "Interaction between S100P and the anti-allergy drug cromolyn". Biochemical and Biophysical Research Communications. 454 (3): 404–409. doi:10.1016/j.bbrc.2014.10.048. PMID 25450399.

Further reading


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