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{{Infobox_gene}}
{{PBB_Controls
'''Rnd1''' is a small (~21 kDa) signaling [[G protein]] (to be specific, a [[GTPase]]), and is a member of the [[rnd protein|Rnd]] subgroup of the [[Rho family of GTPases]].<ref name=Ridley>{{cite journal | vauthors = Ridley AJ | title = Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking | journal = Trends in Cell Biology | volume = 16 | issue = 10 | pages = 522–9 | date = Oct 2006 | pmid = 16949823 | doi = 10.1016/j.tcb.2006.08.006 }}</ref> It is encoded by the gene '''RND1'''.<ref name="entrez">{{cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_RND1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cls.
| PDB = {{PDB2|2cls}}
| Name = Rho family GTPase 1
| HGNCid = 18314
| Symbol = RND1
| AltSymbols =; ARHS; FLJ42294; RHO6
| OMIM = 609038
| ECnumber = 
| Homologene = 8706
| MGIid = 2444878
| GeneAtlas_image1 = PBB_GE_RND1_210056_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005912 |text = adherens junction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0016322 |text = neuron remodeling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27289
    | Hs_Ensembl = ENSG00000172602
    | Hs_RefseqProtein = NP_055285
    | Hs_RefseqmRNA = NM_014470
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 47537198
    | Hs_GenLoc_end = 47545948
    | Hs_Uniprot = Q92730
    | Mm_EntrezGene = 223881
    | Mm_Ensembl = ENSMUSG00000054855
    | Mm_RefseqmRNA = NM_172612
    | Mm_RefseqProtein = NP_766200
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 98497239
    | Mm_GenLoc_end = 98505495
    | Mm_Uniprot = Q8BLR7
  }}
}}
'''Rnd1''' is a small (~21 kDa) signaling [[G protein]] (more specifically a [[GTPase]]), and is a member of the [[rnd protein|Rnd]] subgroup of the [[Rho family of GTPases]].<ref name=Ridley>{{cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522-9 |issn=0962-8924}}</ref>. It is encoded by the gene '''RND1'''.<ref name="entrez">{{cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = }}</ref>


It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = }}</ref>
== Interactions ==


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Rnd1 has been shown to [[Protein-protein interaction|interact]] with [[GRB7]],<ref name=pmid10664463>{{cite journal | vauthors = Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J | title = Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family | journal = FEBS Letters | volume = 467 | issue = 1 | pages = 91–6 | date = Feb 2000 | pmid = 10664463 | doi = 10.1016/S0014-5793(99)01530-6 }}</ref> [[PLXNB1]],<ref name=pmid12730235>{{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}</ref> [[PDE6D]],<ref name=pmid11786539>{{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}</ref><ref name=pmid11980706>{{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}</ref> [[ARHGAP5]]<ref name=pmid12842009>{{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Current Biology | volume = 13 | issue = 13 | pages = 1106–15 | date = Jul 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 }}</ref> and [[UBXD5]].<ref name=pmid11940653>{{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2952–64 | date = May 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/MCB.22.9.2952-2964.2002 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P | title = A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion | journal = The Journal of Cell Biology | volume = 141 | issue = 1 | pages = 187–97 | date = Apr 1998 | pmid = 9531558 | pmc = 2132722 | doi = 10.1083/jcb.141.1.187 }}
| citations =
* {{cite journal | vauthors = Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J | title = Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family | journal = FEBS Letters | volume = 467 | issue = 1 | pages = 91–6 | date = Feb 2000 | pmid = 10664463 | doi = 10.1016/S0014-5793(99)01530-6 }}
*{{cite journal | author=Nobes CD, Lauritzen I, Mattei MG, ''et al.'' |title=A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. |journal=J. Cell Biol. |volume=141 |issue= 1 |pages= 187-97 |year= 1998 |pmid= 9531558 |doi= }}
* {{cite journal | vauthors = Aoki J, Katoh H, Mori K, Negishi M | title = Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 3 | pages = 604–8 | date = Nov 2000 | pmid = 11095956 | doi = 10.1006/bbrc.2000.3842 }}
*{{cite journal | author=Vayssière B, Zalcman G, Mahé Y, ''et al.'' |title=Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 91-6 |year= 2000 |pmid= 10664463 |doi= }}
* {{cite journal | vauthors = Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW | title = The semaphorin 3A receptor may directly regulate the activity of small GTPases | journal = FEBS Letters | volume = 486 | issue = 1 | pages = 68–72 | date = Dec 2000 | pmid = 11108845 | doi = 10.1016/S0014-5793(00)02240-7 }}
*{{cite journal | author=Aoki J, Katoh H, Mori K, Negishi M |title=Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 604-8 |year= 2001 |pmid= 11095956 |doi= 10.1006/bbrc.2000.3842 }}
* {{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}
*{{cite journal | author=Rohm B, Rahim B, Kleiber B, ''et al.'' |title=The semaphorin 3A receptor may directly regulate the activity of small GTPases. |journal=FEBS Lett. |volume=486 |issue= 1 |pages= 68-72 |year= 2001 |pmid= 11108845 |doi= }}
* {{cite journal | vauthors = Katoh H, Harada A, Mori K, Negishi M | title = Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2952–64 | date = May 2002 | pmid = 11940653 | pmc = 133765 | doi = 10.1128/MCB.22.9.2952-2964.2002 }}
*{{cite journal | author=Nancy V, Callebaut I, El Marjou A, de Gunzburg J |title=The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15076-84 |year= 2002 |pmid= 11786539 |doi= 10.1074/jbc.M109983200 }}
* {{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
*{{cite journal | author=Katoh H, Harada A, Mori K, Negishi M |title=Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2952-64 |year= 2002 |pmid= 11940653 |doi= }}
* {{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}
*{{cite journal | author=Hanzal-Bayer M, Renault L, Roversi P, ''et al.'' |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095-106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095 }}
* {{cite journal | vauthors = Oinuma I, Ishikawa Y, Katoh H, Negishi M | title = The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras | journal = Science | volume = 305 | issue = 5685 | pages = 862–5 | date = Aug 2004 | pmid = 15297673 | doi = 10.1126/science.1097545 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Harada A, Katoh H, Negishi M | title = Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells | journal = The Journal of Biological Chemistry | volume = 280 | issue = 18 | pages = 18418–24 | date = May 2005 | pmid = 15738000 | doi = 10.1074/jbc.M411356200 }}
*{{cite journal  | author=Oinuma I, Katoh H, Harada A, Negishi M |title=Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25671-7 |year= 2003 |pmid= 12730235 |doi= 10.1074/jbc.M303047200 }}
* {{cite journal | vauthors = Kim YS, Hori M, Yasuda K, Ozaki H | title = Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria | journal = Comparative Biochemistry and Physiology A | volume = 142 | issue = 4 | pages = 410–5 | date = Dec 2005 | pmid = 16311049 | doi = 10.1016/j.cbpa.2005.08.028 }}
*{{cite journal | author=Oinuma I, Ishikawa Y, Katoh H, Negishi M |title=The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. |journal=Science |volume=305 |issue= 5685 |pages= 862-5 |year= 2004 |pmid= 15297673 |doi= 10.1126/science.1097545 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Harada A, Katoh H, Negishi M |title=Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18418-24 |year= 2005 |pmid= 15738000 |doi= 10.1074/jbc.M411356200 }}
*{{cite journal | author=Kim YS, Hori M, Yasuda K, Ozaki H |title=Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria. |journal=Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |volume=142 |issue= 4 |pages= 410-5 |year= 2006 |pmid= 16311049 |doi= 10.1016/j.cbpa.2005.08.028 }}
}}
{{refend}}
{{refend}}


{{gene-12-stub}}
{{PDB Gallery|geneid=27289}}


{{Rho family of GTPases}}
{{Rho family of GTPases}}
{{gene-12-stub}}

Latest revision as of 21:02, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1] It is encoded by the gene RND1.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]

Interactions

Rnd1 has been shown to interact with GRB7,[3] PLXNB1,[4] PDE6D,[5][6] ARHGAP5[7] and UBXD5.[8]

References

  1. ↑ Ridley AJ (Oct 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  2. ↑ 2.0 2.1 "Entrez Gene: RND1 Rho family GTPase 1".
  3. ↑ Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. PMID 10664463.
  4. ↑ Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  5. ↑ Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
  6. ↑ Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  7. ↑ Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Current Biology. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009.
  8. ↑ Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular Biology. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. PMC 133765. PMID 11940653.

Further reading


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