Ribosomal protein SA

Ribosomal protein SA
Identifiers
Symbols	RPSA ; 37LRP; 67LR; LAMBR; LAMR1; LRP; p40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68249
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ribosomal protein SA, also known as RPSA, is a human gene.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The RPSA gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Further reading

• Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280–301. doi:10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O. PMID 11054877.
• Satoh K, Narumi K, Sakai T; et al. (1992). "Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung". Cancer Lett. 62 (3): 199–203. PMID 1534510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wewer UM, Liotta LA, Jaye M; et al. (1986). "Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin". Proc. Natl. Acad. Sci. U.S.A. 83 (19): 7137–41. PMID 2429301.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van den Ouweland AM, Van Duijnhoven HL, Deichmann KA; et al. (1989). "Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes". Nucleic Acids Res. 17 (10): 3829–43. PMID 2543954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yow HK, Wong JM, Chen HS; et al. (1988). "Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6394–8. PMID 2970639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gehlsen KR, Dillner L, Engvall E, Ruoslahti E (1988). "The human laminin receptor is a member of the integrin family of cell adhesion receptors". Science. 241 (4870): 1228–9. PMID 2970671.CS1 maint: Multiple names: authors list (link)
• Selvamurugan N, Eliceiri GL (1996). "The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene". Genomics. 30 (2): 400–1. PMID 8586453.
• Vladimirov SN, Ivanov AV, Karpova GG; et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. PMID 8706699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jackers P, Minoletti F, Belotti D; et al. (1996). "Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3". Oncogene. 13 (3): 495–503. PMID 8760291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clausse N, Jackers P, Jarès P; et al. (1997). "Identification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein". DNA Cell Biol. 15 (12): 1009–23. PMID 8985115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daidone MG, Silvestrini R, Benini E; et al. (1997). "Expression of high-affinity 67-kDa laminin receptors in primary breast cancers and metachronous metastatic lesions or contralateral cancers". Br. J. Cancer. 76 (1): 52–3. PMID 9218732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kenmochi N, Kawaguchi T, Rozen S; et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. PMID 9582194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Manzoni G, Guglielmi A, Verlato G; et al. (1998). "Prognostic significance of 67-kDa laminin receptor expression in advanced gastric cancer". Oncology. 55 (5): 456–60. PMID 9732225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato M, Saeki Y, Tanaka K, Kaneda Y (1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochem. Biophys. Res. Commun. 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. PMID 10079194.CS1 maint: Multiple names: authors list (link)
• Canfield SM, Khakoo AY (1999). "The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin". J. Immunol. 163 (6): 3430–40. PMID 10477615.
• Donaldson EA, McKenna DJ, McMullen CB; et al. (2000). "The expression of membrane-associated 67-kDa laminin receptor (67LR) is modulated in vitro by cell-contact inhibition". Mol. Cell Biol. Res. Commun. 3 (1): 53–9. doi:10.1006/mcbr.2000.0191. PMID 10683318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pedraza C, Geberhiwot T, Ingerpuu S; et al. (2000). "Monocytic cells synthesize, adhere to, and migrate on laminin-8 (alpha 4 beta 1 gamma 1)". J. Immunol. 165 (10): 5831–8. PMID 11067943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vande Broek I, Vanderkerken K, De Greef C; et al. (2001). "Laminin-1-induced migration of multiple myeloma cells involves the high-affinity 67 kD laminin receptor". Br. J. Cancer. 85 (9): 1387–95. doi:10.1054/bjoc.2001.2078. PMID 11720479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waltregny D, de Leval L, Coppens L; et al. (2002). "Detection of the 67-kD laminin receptor in prostate cancer biopsies as a predictor of recurrence after radical prostatectomy". Eur. Urol. 40 (5): 495–503. PMID 11752855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)