View source for Rhabdomyosarcoma history and symptoms

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{{Rhabdomyosarcoma}}
{{CMG}} ;{{AE}} {{S.M}}
==Overview==
[[Symptoms]] of [[rhabdomyosarcoma]] can vary greatly depending on the size, location and spread of the [[tumor]]. General [[symptoms]] of [[rhabdomyosarcoma]] are [[palpable]] [[mass]], [[pain]], erythmatous [[skin]], [[fever]], [[nasal]] [[discharge]], [[headache]], [[vomiting]], change in [[hearing]], [[vision]], [[speech]], or [[swallowing]]. Specific [[symptoms]] of parameningeal [[rhabdomyosarcoma]] are [[headache]] and [[facial]] asymmetry. [[Symptoms]] of [[rhabdomyosarcoma]] of [[orbit]] are [[proptosis]] and [[vision]] problems. [[Symptoms]] of [[pelvic]] or [[abdominal]] [[rhabdomyosarcoma]] are [[vomiting]], [[constipation]], and [[abdominal]] [[pain]].
==History and Symptoms==
*[[Symptoms]] of [[rhabdomyosarcoma]] can vary greatly depending on the size, location, patient's [[age]] and [[tumor]] [[metastases]].<ref name="pmid24966711">{{cite journal| author=Egas-Bejar D, Huh WW| title=Rhabdomyosarcoma in adolescent and young adult patients: current perspectives. | journal=Adolesc Health Med Ther | year= 2014 | volume= 5 | issue=  | pages= 115-25 | pmid=24966711 | doi=10.2147/AHMT.S44582 | pmc=4069040 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24966711  }}</ref><ref>Kaseb H, Babiker HM. Cancer, Rhabdomyosarcoma. [Updated 2018 Oct 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507721/</ref>
*[[Patients]] with [[rhabdomyosarcoma]] have negative previous history of [[trauma]].
* General [[symptoms]] of [[rhabdomyosarcoma]] are:
** [[Palpable]] [[mass]]
** [[Pain]] may be present
** Erythmatous [[skin]]
** [[Fever]] may be present
** [[Nasal]] [[discharge]]
** [[headache]]
** [[Vomiting]]
** Change in [[hearing]], [[vision]], [[speech]], or [[swallowing]]
* Most [[symptoms]] are related to prevalent sites of involvement such as:<ref name="pmid15728225">{{cite journal| author=Stevens MC, Rey A, Bouvet N, Ellershaw C, Flamant F, Habrand JL et al.| title=Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89. | journal=J Clin Oncol | year= 2005 | volume= 23 | issue= 12 | pages= 2618-28 | pmid=15728225 | doi=10.1200/JCO.2005.08.130 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15728225  }}</ref>
** [[Head]] and [[neck]] [[mass]] [[symptoms]]
** [[Genitourinary tract]] [[mass]] [[symptoms]]
** Extremity [[mass]] [[symptoms]]
* [[Symptoms]] related to [[metastases]] [[lesions]] are:<ref name="pmid24966711" />
** [[Bone]] [[pain]]
** [[Respiratory]] difficulties
** [[Abnormal]] lab [[test]] ( [[anemia]], [[thrombocytopenia]], and [[neutropenia]])
** Disseminated rhabdomyoblasts in the [[bone marrow]] present with [[leukemia]] [[symptoms]]
* Specific [[rhabdomyosarcoma]] [[symptoms]] based on [[origin]] site are described as below:<ref name="pmid12110339">{{cite journal| author=Hicks J, Flaitz C| title=Rhabdomyosarcoma of the head and neck in children. | journal=Oral Oncol | year= 2002 | volume= 38 | issue= 5 | pages= 450-9 | pmid=12110339 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12110339  }}</ref><ref name="pmid1433603">{{cite journal| author=Shapiro E, Strother D| title=Pediatric genitourinary rhabdomyosarcoma. | journal=J Urol | year= 1992 | volume= 148 | issue= 6 | pages= 1761-8 | pmid=1433603 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1433603  }}</ref>
{| class="wikitable"
|+symptoms based on origin
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Origin
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Presentation
|-
| style="background:#DCDCDC;" align="center" + |[[Orbit]]<ref name="pmid235770292">{{cite journal| author=Rao AA, Naheedy JH, Chen JY, Robbins SL, Ramkumar HL| title=A clinical update and radiologic review of pediatric orbital and ocular tumors. | journal=J Oncol | year= 2013 | volume= 2013 | issue=  | pages= 975908 | pmid=23577029 | doi=10.1155/2013/975908 | pmc=3610355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23577029  }}</ref>
| style="background:#F5F5F5;" + |[[Proptosis]]/ dysconjugate gaze/ ophtalmoplasia
|-
| style="background:#DCDCDC;" align="center" + |Parameningeal [[lesions]]*<ref name="pmid23719406">{{cite journal| author=Rahman HA, Sedky M, Mohsen I, Taha H, Loaye I, Zaghloul MS et al.| title=Outcome of pediatric parameningeal rhabdomyosarcoma. The Children Cancer Hospital, Egypt, experience. | journal=J Egypt Natl Canc Inst | year= 2013 | volume= 25 | issue= 2 | pages= 79-86 | pmid=23719406 | doi=10.1016/j.jnci.2013.01.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23719406  }}</ref>
| style="background:#F5F5F5;" + |Upper [[respiratory]] [[symptoms]] such as [[sinus]] or [[nasal]] [[obstruction]] with or without a [[mucopurulent]] or bloody [[discharge]]
|-
| style="background:#DCDCDC;" align="center" + |[[Bladder]]
| style="background:#F5F5F5;" + |[[Hematuria]], [[urinary]] [[obstruction]]
|-
| style="background:#DCDCDC;" align="center" + |[[Prostate]]
| style="background:#F5F5F5;" + |[[Urinary]] [[frequency]], [[constipation]] due to [[tumoral]] [[pressure]]
|-
| style="background:#DCDCDC;" align="center" + |Paratesticular [[lesions]]
| style="background:#F5F5F5;" + |[[Scrotal mass|Scrotal]] or [[inguinal]] enlargement, usually [[painful]] [[mass]]
|-
| style="background:#DCDCDC;" align="center" + |[[Uterus]] or [[cervix]]
| style="background:#F5F5F5;" + |[[Menorrhagia]] or [[metrorrhagia]]
|-
| style="background:#DCDCDC;" align="center" + |[[Vagina]]
| style="background:#F5F5F5;" + |Mucosanguineous [[discharge]] in very young girls, protrusion of [[Polyploidy|polypoid]] [[mass]] from [[vagina]]
|-
| style="background:#DCDCDC;" align="center" + |[[Extremities]]
| style="background:#F5F5F5;" + |[[Painful]] or painless [[mass]] with or without erythematous [[skin]]
|}
<nowiki>*</nowiki>Prameningeal [[lesions]] include masses in [[ear]], [[mastoid]], [[nasal]] [[cavity]], [[paranasal sinuses]], [[infratemporal fossa]], [[pterygopalatine fossa]].

==References==
{{reflist|2}}

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