Retinoblastoma other diagnostic studies: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 25: Line 25:
==References==
==References==
{{reflist|2}}
{{reflist|2}}
 
[[Category:Medicine]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
 
[[Category:Disease]]
[[Category:Ophthalmology]]
[[Category:hereditary cancers]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Up-To-Date]]
[[Category:Ophthalmology]]
[[Category:Primary care]]
[[Category:Surgery]]

Revision as of 17:56, 15 May 2019

Retinoblastoma Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Retinoblastoma from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural history, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History & Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Retinoblastoma other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Retinoblastoma other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Retinoblastoma other diagnostic studies

CDC on Retinoblastoma other diagnostic studies

Retinoblastoma other diagnostic studies in the news

Blogs on Retinoblastoma other diagnostic studies

Directions to Hospitals Treating Retinoblastoma

Risk calculators and risk factors for Retinoblastoma other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Other diagnostic studies for retinoblastoma include fluorescein angiography, bone marrow aspiration, lumbar puncture, bone scan, and genetic testing.

Other Diagnostic Studies

Fluorescein angiography

This imaging study can be used to differentiate retinoblastoma from other lesions.[1]

Bone marrow aspiration

Bone marrow aspiration is usually done only if the optic nerve contains cancer, which suggests that cancer may have spread outside the eye. It may also be done in patients who undergo enucleation and in whom the tumor is found at the cut section of the optic nerve.[2]

Lumbar puncture

Lumbar puncture may be done if the optic nerve or a large portion of the choroid contains cancer, which suggests that there is a risk that cancer has spread outside the eye.[3]

Bone scan

A bone scan is not used very often during the diagnosis and staging of retinoblastoma. It is usually only done if there is the reason to believe that cancer has spread outside the eye.[3]

Genetic testing

Scientists have recently developed genetic tests to tell if there are changes to a gene (gene mutations). Gene testing involves looking at a person’s DNA. A test is done on blood or tissue to search for retinoblastoma 1 (RB1) gene mutations. Genetic testing may also be done in another family member, such as the child’s parents or siblings, especially if there is a family history of retinoblastoma or if the child is found to have a germline mutation. RB1 gene mutation happens in a parent’s egg or sperm before conception and is passed on to the child. The genetic testing does not guide ocular therapy, but the presence of a germinal mutation can be helpful for the screening of secondary cancers and family planning.[3]

Biopsy/FNAC

Unlike most other cancers, which need a biopsy to confirm the diagnosis, retinoblastoma can usually be diagnosed by an eye examination and imaging. A biopsy is not needed in many cases because of risk of orbital seeding and metastasis.[3]

References

  1. Singh, Arun D. (2016). "Retinoblastoma: Evaluation and Differential Diagnosis". 7: 91–99. doi:10.1159/000442228. ISSN 1664-882X.
  2. Mohney BG, Robertson DM (1994). "Ancillary testing for metastasis in patients with newly diagnosed retinoblastoma". Am J Ophthalmol. 118 (6): 707–11. PMID 7977596.
  3. 3.0 3.1 3.2 3.3 Retinoblastoma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/retinoblastoma/diagnosis/?region=on Accessed on October 13 2015