Reperfusion injury risk factors

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Editors-In-Chief: Anjan K. Chakrabarti, M.D. [1]; C. Michael Gibson, M.S., M.D. [2]; Associate Editors-In-Chief: Kashish Goel, M.D.

Overview

It is important to identify the risk factors associated with worse reperfusion injury in STEMI patients. This may help in early risk stratification and determine therapy targets after discharge from the hospital. Most of the association is based on animal studies and includes:

1. Left Ventricular hypertrophy: Long-standing hypertension leads to pressure overload hypertrophy. This is associated with metabolic and biochemical changes, predisposing the myocardium to severe repercussion injury. Moreover, increase in lactate dehydrogenase and creatine kinase release after reperfusion increases the susceptibility of the hypertrophied heart to ischemia/reperfusion injury.

1. Hear failure: