Reperfusion injury risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anjan K. Chakrabarti, M.D. [2] Kashish Goel, M.D. Shivam Singla, M.D.[3]

Overview

Risk Factors

Risk factors for reperfusion injury include

It is important to identify the risk factors associated with worse reperfusion injury in STEMI patients. This may help in early risk stratification and develop therapeutic targets to reduce the infarct size associated with reperfusion injury. These risk factors also increase the risk of a first cardiac event and emphasize the importance of secondary prevention. Most of these associations are based on animal studies and includes:

References

  1. Ferdinandy P, Schulz R, Baxter GF (December 2007). "Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning". Pharmacol. Rev. 59 (4): 418–58. doi:10.1124/pr.107.06002. PMID 18048761.
  2. "Ischemia Reperfusion Injury, Pipeline Review, H1 2020 - Risk Factors Include Hypertension, Hyperlipidemia, Diabetes, Insulin Resistance, Heart Failure, Altered Coronary Circulation & Aging - ResearchAndMarkets.com | Business Wire".