Reperfusion injury risk factors

Revision as of 00:01, 12 August 2020 by Shivam Singla (talk | contribs)
Jump to navigation Jump to search

Reperfusion injury Microchapters

Home

Overview

Pathophysiology

Risk Factors

Natural History, Complications & Prognosis

Treatment

Medical Therapy

Future or Investigational Therapies

Reperfusion injury risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Reperfusion injury risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Reperfusion injury risk factors

CDC on Reperfusion injury risk factors

Reperfusion injury risk factors in the news

Blogs on Reperfusion injury risk factors

Directions to Hospitals Treating Reperfusion injury

Risk calculators and risk factors for Reperfusion injury risk factors

Editors-In-Chief: Anjan K. Chakrabarti, M.D. [1]; C. Michael Gibson, M.S., M.D. [2]; Dr. Shivam Singla M.D. [2] ;Associate Editors-In-Chief: Kashish Goel, M.D.,


Risk Factors

It is important to identify the risk factors associated with worse reperfusion injury in STEMI patients. This may help in early risk stratification and develop therapy targets to reduce the infarct size associated with reperfusion injury. These risk factors also increase the risk of first cardiac event and emphasizes the importance of secondary prevention. Most of these associations are based on animal studies and includes:

  • Left Ventricular hypertrophy: Long-standing hypertension leads to pressure overload hypertrophy. This is associated with metabolic and biochemical changes, predisposing the myocardium to severe reperfusion injury. Moreover, increase in lactate dehydrogenase and creatine kinase release after reperfusion increases the susceptibility of the hypertrophied heart to ischemia/reperfusion injury.
  • Heart failure: Left ventricular dysfunction may predispose the heart to reperfusion injury.
  • Age: Aging is associated with oxidative stress as well as impaired systolic and diastolic function, increasing the risk related to reperfusion injury.
  • Diabetes: The data from preclinical studies in diabetic patients is not clear, however there is clearly increased susceptibility of the heart to ischemic stress and possibly reperfusion.
  • Hyperlipidemia: Hyperlipidemia is a known risk factor for ischemic heart disease. Animal and human studies have shown that presence of hyperlipidemia increases the risk of reperfusion injury and may also attenuate the protective effect of ischemic preconditioning.

References