Reperfusion injury risk factors: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(One intermediate revision by the same user not shown)
Line 12: Line 12:
* [[Hypertension]] with [[left ventricular hypertrophy]],
* [[Hypertension]] with [[left ventricular hypertrophy]],
* [[Congestive heart failure]]
* [[Congestive heart failure]]
* Increased age,
* Increased age<ref name="urlFundamentals of Reperfusion Injury for the Clinical Cardiologist | Circulation">{{cite web |url=https://www.ahajournals.org/doi/full/10.1161/01.cir.0000016602.96363.36 |title=Fundamentals of Reperfusion Injury for the Clinical Cardiologist &#124; Circulation |format= |work= |accessdate=}}</ref>,
* [[Diabetes]], and
* [[Diabetes]], and
* [[Hyperlipidemia]]
* [[Hyperlipidemia]]
Line 31: Line 31:


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}



Latest revision as of 19:19, 21 August 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief: Anjan K. Chakrabarti, M.D. [3]Shivam Singla, M.D.[4] Kashish Goel, M.D.

Overview

Ischemia reperfusion injury is a complex disorder associated with various cardiovascular and other risk factors mainly including Hypertension, hyperlipidemia, Diabetes, Insulin resistance, aging, and defects with coronary artery circulation. Although the exact mechanism about how these causes injuries are still not clear but studies have done so far best explains their role in mediating oxidative stress and endothelial cell dysfunctions, the two most important pathophysiological processes involved in the mediation of injury.

Risk Factors

Risk Factors Ischemia Reperfusion Injury. Various cardiovascular and non-cardiovascular risk factors involved in the potentiation and aggravation of Ischemia-reperfusion injury. [1]

Risk factors for reperfusion injury include[1]

It is important to identify the risk factors associated with worse reperfusion injury in STEMI patients. This may help in early risk stratification and develop therapeutic targets to reduce the infarct size associated with reperfusion injury. These risk factors also increase the risk of a first cardiac event and emphasize the importance of secondary prevention. Most of these associations are based on animal studies and includes:

References

  1. "Ischemia‐Reperfusion: Mechanisms of Microvascular Dysfunction and the Influence of Risk Factors for Cardiovascular Disease - GRANGER - 1999 - Microcirculation - Wiley Online Library".
  2. "Fundamentals of Reperfusion Injury for the Clinical Cardiologist | Circulation".
  3. "Ischemia Reperfusion Injury - Pipeline Review, H2 2020".