Reni Syndrome: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
==Overview== | ==Overview== | ||
''' RENI syndrome''' (RENI) is a [[genetic]] condition characterized by steroid-resistant [[nephrotic syndrome]] (SNRS) and a range of multisystemic manifestations. RENI [[syndrome]] (RENI) results from a homozygous or compound [[heterozygous]] [[mutation]] in the [[SGPL1]] [[gene]] located on [[chromosome]] 10q21. | ''' RENI syndrome''' (RENI) is a [[genetic]] condition characterized by steroid-resistant [[nephrotic syndrome]] (SNRS) and a range of multisystemic manifestations. RENI [[syndrome]] (RENI) results from a homozygous or compound [[heterozygous]] [[mutation]] in the [[SGPL1]] [[gene]] located on [[chromosome]] 10q21. | ||
==Historical Perspective== | ==Historical Perspective== | ||
The autosomal recessive inheritance association was first reported by [[Prasad et. al]] and [[Lovric et. al]] in 2017. In 2017, Prasad et al. found that the homozygous loss-of-function mutations in the SGLP-1 gene are causing [[primary adrenal insufficiency]], steroid-resistant nephrotic syndrome (SRNS), [[primary hypothyroidism]], neurological symptoms, and [[cryptorchidism]]. <ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> In the same year, Lovric et al. found that [[autosomal recessive]] mutations in SGPL1 also can cause [[facultative ichthyosis]], [[adrenal insufficiency]], [[neurologic]] involvement, and [[immunodeficiency]]. Renal biopsies also showed [[focal segmental glomerulosclerosis]] ([[FSGS]]) and [[diffuse mesangial sclerosis]] ([[DMS]]) <ref name="pmid28165339">{{cite journal| author=Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI | display-authors=etal| title=Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 912-928 | pmid=28165339 | doi=10.1172/JCI89626 | pmc=5330730 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165339 }} </ref> | The autosomal recessive inheritance association was first reported by [[Prasad et. al]] and [[Lovric et. al]] in 2017. In 2017, Prasad et al. found that the homozygous loss-of-function mutations in the SGLP-1 gene are causing [[primary adrenal insufficiency]], steroid-resistant nephrotic syndrome (SRNS), [[primary hypothyroidism]], neurological symptoms, and [[cryptorchidism]]. <ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> In the same year, Lovric et al. found that [[autosomal recessive]] mutations in SGPL1 also can cause [[facultative ichthyosis]], [[adrenal insufficiency]], [[neurologic]] involvement, and [[immunodeficiency]]. Renal biopsies also showed [[focal segmental glomerulosclerosis]] ([[FSGS]]) and [[diffuse mesangial sclerosis]] ([[DMS]]) <ref name="pmid28165339">{{cite journal| author=Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI | display-authors=etal| title=Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 912-928 | pmid=28165339 | doi=10.1172/JCI89626 | pmc=5330730 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165339 }} </ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
RENI syndrome is a rare genetic disorder caused by mutations in the SGPL1 gene. These mutations result in the loss of a [[protein]] that regulates a signaling molecule in the body. As a result, patients with RENI syndrome experience problems in their [[kidneys]], [[adrenal glands]], and [[skin]]. The mutations disrupt the balance of certain [[lipid]] molecules, affecting the immune system and various body tissues. Multiple studies have provided evidence linking SGPL1 gene mutations to this disorder. <ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> <ref name="pmid28165339">{{cite journal| author=Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI | display-authors=etal| title=Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 912-928 | pmid=28165339 | doi=10.1172/JCI89626 | pmc=5330730 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165339 }} </ref> <ref name="pmid36873630">{{cite journal| author=Yang S, He Y, Zhou J, Yuan H, Qiu L| title=Steroid-resistant nephrotic syndrome associated with certain SGPL1 variants in a family: Case report and literature review. | journal=Front Pediatr | year= 2023 | volume= 11 | issue= | pages= 1079758 | pmid=36873630 | doi=10.3389/fped.2023.1079758 | pmc=9978203 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=36873630 }} </ref> | RENI syndrome is a rare genetic disorder caused by mutations in the SGPL1 gene. These mutations result in the loss of a [[protein]] that regulates a signaling molecule in the body. As a result, patients with RENI syndrome experience problems in their [[kidneys]], [[adrenal glands]], and [[skin]]. The mutations disrupt the balance of certain [[lipid]] molecules, affecting the immune system and various body tissues. Multiple studies have provided evidence linking SGPL1 gene mutations to this disorder. <ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> <ref name="pmid28165339">{{cite journal| author=Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI | display-authors=etal| title=Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 912-928 | pmid=28165339 | doi=10.1172/JCI89626 | pmc=5330730 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165339 }} </ref> <ref name="pmid36873630">{{cite journal| author=Yang S, He Y, Zhou J, Yuan H, Qiu L| title=Steroid-resistant nephrotic syndrome associated with certain SGPL1 variants in a family: Case report and literature review. | journal=Front Pediatr | year= 2023 | volume= 11 | issue= | pages= 1079758 | pmid=36873630 | doi=10.3389/fped.2023.1079758 | pmc=9978203 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=36873630 }} </ref> | ||
==Causes== | ==Causes== | ||
*The mutations in the SGPL1 gene lead to a loss of function of the SGPL1 protein and its enzyme activity. This protein plays a role in regulating the levels of a signaling molecule called S1P. | * Researchers identified mutations in the SGPL1 gene in multiple patients with RENI syndrome. These mutations are responsible for the [[disorder]] and are often [[homozygous]] or compound [[heterozygous]], meaning that the affected individuals [[inherit]] two mutated copies of the gene. | ||
*The mutations in the SGPL1 gene lead to a loss of function of the SGPL1 protein and its [[enzyme]] activity. This protein plays a role in regulating the levels of a signaling molecule called S1P. | |||
*SGPL1 deficiency affects various tissues in the body, including the adrenal glands, leading to adrenal insufficiency. It can also cause kidney problems and skin-related issues like ichthyosis. | *SGPL1 deficiency affects various tissues in the body, including the adrenal glands, leading to adrenal insufficiency. It can also cause kidney problems and skin-related issues like ichthyosis. | ||
| Line 26: | Line 30: | ||
==Classification== | ==Classification== | ||
There is no established system for the classification of Reni Syndrome. | There is no established system for the classification of Reni Syndrome. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
*Most affected patients present in infancy or early childhood.<ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> | *Most affected patients present in infancy or early childhood.<ref name="pmid28165343">{{cite journal| author=Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M | display-authors=etal| title=Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. | journal=J Clin Invest | year= 2017 | volume= 127 | issue= 3 | pages= 942-953 | pmid=28165343 | doi=10.1172/JCI90171 | pmc=5330744 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28165343 }} </ref> | ||
*The youngest age of onset of disease was a day after birth, the oldest age is 19 years. | *The youngest age of onset of disease was a day after birth, the oldest age is 19 years.<ref name="pmid36873630">{{cite journal| author=Yang S, He Y, Zhou J, Yuan H, Qiu L| title=Steroid-resistant nephrotic syndrome associated with certain SGPL1 variants in a family: Case report and literature review. | journal=Front Pediatr | year= 2023 | volume= 11 | issue= | pages= 1079758 | pmid=36873630 | doi=10.3389/fped.2023.1079758 | pmc=9978203 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=36873630 }} </ref> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
==Risk Factors== | ==Risk Factors== | ||
==Screening== | ==Screening== | ||
==Natural History, Complications and Prognosis== | |||
==Diagnosis== | |||
===Diagnostic Study of Choice=== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Electrocardiogram=== | |||
===X-ray=== | |||
===Echocardiography or Ultrasound=== | |||
===CT scan=== | |||
===MRI=== | |||
===Other Imaging Findings=== | |||
*There are no other imaging findings that may be used to diagnose Reni syndrome. | |||
===Other Diagnostic Studies=== | |||
*There are no other diagnostic studies that may be used to diagnose Reni syndrome. | |||
==Treatment== | |||
Revision as of 23:07, 22 November 2023
Editor In Chief: C. Michael Gibson, M.S., M.D. ; Associate Editor(s)-in-Chief: Alara E. Dagsali
Overview
RENI syndrome (RENI) is a genetic condition characterized by steroid-resistant nephrotic syndrome (SNRS) and a range of multisystemic manifestations. RENI syndrome (RENI) results from a homozygous or compound heterozygous mutation in the SGPL1 gene located on chromosome 10q21.
Historical Perspective
The autosomal recessive inheritance association was first reported by Prasad et. al and Lovric et. al in 2017. In 2017, Prasad et al. found that the homozygous loss-of-function mutations in the SGLP-1 gene are causing primary adrenal insufficiency, steroid-resistant nephrotic syndrome (SRNS), primary hypothyroidism, neurological symptoms, and cryptorchidism. [1] In the same year, Lovric et al. found that autosomal recessive mutations in SGPL1 also can cause facultative ichthyosis, adrenal insufficiency, neurologic involvement, and immunodeficiency. Renal biopsies also showed focal segmental glomerulosclerosis (FSGS) and diffuse mesangial sclerosis (DMS) [2]
Pathophysiology
RENI syndrome is a rare genetic disorder caused by mutations in the SGPL1 gene. These mutations result in the loss of a protein that regulates a signaling molecule in the body. As a result, patients with RENI syndrome experience problems in their kidneys, adrenal glands, and skin. The mutations disrupt the balance of certain lipid molecules, affecting the immune system and various body tissues. Multiple studies have provided evidence linking SGPL1 gene mutations to this disorder. [1] [2] [3]
Causes
- Researchers identified mutations in the SGPL1 gene in multiple patients with RENI syndrome. These mutations are responsible for the disorder and are often homozygous or compound heterozygous, meaning that the affected individuals inherit two mutated copies of the gene.
- The mutations in the SGPL1 gene lead to a loss of function of the SGPL1 protein and its enzyme activity. This protein plays a role in regulating the levels of a signaling molecule called S1P.
- SGPL1 deficiency affects various tissues in the body, including the adrenal glands, leading to adrenal insufficiency. It can also cause kidney problems and skin-related issues like ichthyosis.
- Changes in S1P metabolism due to SGPL1 mutations have systemic effects, including the accumulation of certain sphingolipid intermediates like ceramides.
- The mutations in SGPL1 can result in alterations in sphingolipid levels, which affect T-cell egress and play a crucial role in various tissues, especially the kidney.
- The types of SGPL1 mutations identified include frameshift, splice site, missense, and truncating mutations, all of which lead to reduced or absent SGPL1 protein and enzyme activity.
- Several studies discussed in the text confirm the association between SGPL1 mutations and RENI syndrome, with functional studies and genetic analyses.
Classification
There is no established system for the classification of Reni Syndrome.
Epidemiology and Demographics
- Most affected patients present in infancy or early childhood.[1]
- The youngest age of onset of disease was a day after birth, the oldest age is 19 years.[3]
Differential Diagnosis
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography or Ultrasound
CT scan
MRI
Other Imaging Findings
- There are no other imaging findings that may be used to diagnose Reni syndrome.
Other Diagnostic Studies
- There are no other diagnostic studies that may be used to diagnose Reni syndrome.
Treatment
- ↑ 1.0 1.1 1.2 Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M; et al. (2017). "Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome". J Clin Invest. 127 (3): 942–953. doi:10.1172/JCI90171. PMC 5330744. PMID 28165343.
- ↑ 2.0 2.1 Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI; et al. (2017). "Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency". J Clin Invest. 127 (3): 912–928. doi:10.1172/JCI89626. PMC 5330730. PMID 28165339.
- ↑ 3.0 3.1 Yang S, He Y, Zhou J, Yuan H, Qiu L (2023). "Steroid-resistant nephrotic syndrome associated with certain SGPL1 variants in a family: Case report and literature review". Front Pediatr. 11: 1079758. doi:10.3389/fped.2023.1079758. PMC 9978203 Check
|pmc=value (help). PMID 36873630 Check|pmid=value (help).