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{{Renal papillary necrosis}}
{{Renal papillary necrosis}}


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{{CMG}}; {{AE}} {{NN}}<br>
===Drug Side Effect===
==Overview==
[[Diclofenac (patch)]]
* [[Renal papillary necrosis]] is associated with damaging the [[renal]] [[medullary]] and [[papillary]] cells due to many diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], [[pyelonephritis]], [[tuberculosis]], [[vasculitis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] abuse.<br>
 
==Causes==
[[Mefenamic acid]]
*Common causes of [[renal papillary necrosis]] include<ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867  }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414  }} </ref>:
 
**[[Diabetes]]
[[Meloxicam]]
**[[Sickle cell disease]]: most common cause in children
 
**[[Urinary tract obstruction]]
[[Piroxicam]]
**[[Renal vein thrombosis]]
 
**upper [[urinary tract infection]] or [[pyelonephritis]]
**[[Tuberculosis]]
** systemic [[vasculitis]]
**[[Renal]] [[transplant rejection]]
**long term [[analgesics]] abuse such as [[acetaminophen]] and [[NSAIDS]]
*** [[NSAIDS]] include:
****[[Aspirin]]
****[[Ibuprofen]]
****[[Mefenamic acid]]
****[[Indomethacin]]
****[[Naproxen]]
****[[Meloxicam]]
****[[Diclofenac]]
****[[Piroxicam]]
****[[ketorolac]]
==References==
==References==



Revision as of 14:14, 28 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]

Overview

Causes

References

  1. Brix AE (2002). "Renal papillary necrosis". Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
  2. Sabatini S (1984). "Pathophysiology of drug-induced papillary necrosis". Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.

[[Category:Disease]