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{{Renal papillary necrosis}}
{{Renal papillary necrosis}}


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{{CMG}}; {{AE}} {{NN}}<br>
==Overview==
* [[Renal papillary necrosis]] is associated with damaging the [[renal]] [[medullary]] and [[papillary]] cells due to many diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], [[pyelonephritis]], [[tuberculosis]], [[vasculitis]], [[cirrhosis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] and [[alcohol]] abuse. In infants, it is associated with [[asphyxia]], [[dehydration]], and [[sepsis]].
<br>
==Causes==
*Common causes of [[renal papillary necrosis]] include<ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867  }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414  }} </ref><ref name="pmid28341428">{{cite journal| author=Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D | display-authors=etal| title=Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis. | journal=J Pediatr Urol | year= 2017 | volume= 13 | issue= 3 | pages= 250-256 | pmid=28341428 | doi=10.1016/j.jpurol.2017.01.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28341428  }} </ref>:
**[[Diabetes]]
**[[Sickle cell disease]]: most common cause in children
**[[Urinary tract obstruction]]
**[[Renal vein thrombosis]]
**upper [[urinary tract infection]] or [[pyelonephritis]]
**[[Tuberculosis]]
**[[liver cirrhosis]]
** systemic [[vasculitis]]
**[[Renal]] [[transplant rejection]]
**chronic [[alcohol abuse]]
**abuse of [[acetaminophen]] and [[analgesics]] containing [[phenacetin]] such as [[NSAIDs]]
*** [[NSAIDs]] include:
****[[Aspirin]]
****[[Ibuprofen]]
****[[Mefenamic acid]]
****[[Indomethacin]]
****[[Naproxen]]
****[[Meloxicam]]
****[[Diclofenac]]
****[[Piroxicam]]
****[[ketorolac]]
**[[Renal papillary necrosis]] may also occur less commonly in [[infants]] due to<ref name="pmid4690507">{{cite journal| author=Husband P, Howlett KA| title=Renal papillary necrosis in infancy. | journal=Arch Dis Child | year= 1973 | volume= 48 | issue= 2 | pages= 116-20 | pmid=4690507 | doi=10.1136/adc.48.2.116 | pmc=1648192 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4690507  }} </ref>:
***[[asphyxia]]
***[[dehydration]]
***[[sepsis]]


===Drug Side Effect===
*There is a [[mnemonic]] for the causes of [[renal papillary necrosis]]<ref>{{Cite book|title = Radiology Illustrated: Uroradiology|url = https://books.google.com/?id=-NrSgSEQGm8C&pg=PA471&lpg=PA471&dq=POSTCARDS++renal+papillary+necrosis#v=onepage&q=POSTCARDS%2520%2520renal%2520papillary%2520necrosis&f=false|publisher = Springer Science & Business Media|date = 2011-11-19|page=471|isbn = 9783642053221|first = Seung Hyup|last = Kim}}</ref> : '''POSTCARDS''':
 
**'''P'''yelonephritis
[[Mefenamic acid]]
**'''O'''bstruction of the urogenital tract
 
**'''S'''ickle cell disease
[[Meloxicam]]
**'''T'''uberculosis
 
**'''C'''irrhosis
[[Piroxicam]]
**'''A'''nalgesia/'''A'''lcohol abuse
**'''R'''enal vein thrombosis
**'''D'''iabetes mellitus
**'''S'''ystemic vasculitis


==References==
==References==

Latest revision as of 04:47, 7 September 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]

Overview


Causes

  • There is a mnemonic for the causes of renal papillary necrosis[5] : POSTCARDS:
    • Pyelonephritis
    • Obstruction of the urogenital tract
    • Sickle cell disease
    • Tuberculosis
    • Cirrhosis
    • Analgesia/Alcohol abuse
    • Renal vein thrombosis
    • Diabetes mellitus
    • Systemic vasculitis

References

  1. ↑ Brix AE (2002). "Renal papillary necrosis". Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
  2. ↑ Sabatini S (1984). "Pathophysiology of drug-induced papillary necrosis". Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.
  3. ↑ Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D; et al. (2017). "Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis". J Pediatr Urol. 13 (3): 250–256. doi:10.1016/j.jpurol.2017.01.020. PMID 28341428.
  4. ↑ Husband P, Howlett KA (1973). "Renal papillary necrosis in infancy". Arch Dis Child. 48 (2): 116–20. doi:10.1136/adc.48.2.116. PMC 1648192. PMID 4690507.
  5. ↑ Kim, Seung Hyup (2011-11-19). Radiology Illustrated: Uroradiology. Springer Science & Business Media. p. 471. ISBN 9783642053221.

[[Category:Disease]

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