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{{CMG}}
__NOTC__
{{Renal cell carcinoma}}
{{Renal cell carcinoma}}
{{CMG}} {{AE}} {{F.K}}
==Overview==
Laboratory findings of renal cell carcinoma include [[anemia]], [[polycythemia]], [[hypercalcemia]], elevated [[ESR]], elevated [[liver function tests]], elevated [[alkaline phosphatase]], elevated [[lactate dehydrogenase]], elevated serum [[creatinine]], [[hematuria]], and [[cancer cells]] on urine cytology.


==Overview==
==Laboratory Findings==
'''Renal cell carcinoma''' is the most common form of '''kidney cancer''' arising from the [[renal tubule]]. It is the most common type of [[kidney]] [[cancer]] in adults.
Laboratory findings consistent with the diagnosis of renal cell carcinoma include:<ref name="pmid5848632">{{cite journal |vauthors=O'Grady AS, Morse LJ, Lee JB |title=Parathyroid hormone-secreting renal carcinoma associated with hypercalcemia and metabolic alkalosis |journal=Ann. Intern. Med. |volume=63 |issue=5 |pages=858–68 |date=November 1965 |pmid=5848632 |doi= |url=}}</ref><ref name="pmid9334578">{{cite journal |vauthors=Chuang YC, Lin AT, Chen KK, Chang YH, Chen MT, Chang LS |title=Paraneoplastic elevation of serum alkaline phosphatase in renal cell carcinoma: incidence and implication on prognosis |journal=J. Urol. |volume=158 |issue=5 |pages=1684–7 |date=November 1997 |pmid=9334578 |doi= |url=}}</ref><ref name="pmid850315">{{cite journal |vauthors=Sufrin G, Mirand EA, Moore RH, Chu TM, Murphy GP |title=Hormones in renal cancer |journal=J. Urol. |volume=117 |issue=4 |pages=433–8 |date=April 1977 |pmid=850315 |doi= |url=}}</ref><ref name="pmid3046641">{{cite journal |vauthors=Nielsen OJ, Jespersen FF, Hilden M |title=Erythropoietin-induced secondary polycythemia in a patient with a renal cell carcinoma. A case report |journal=APMIS |volume=96 |issue=8 |pages=688–94 |date=August 1988 |pmid=3046641 |doi= |url=}}</ref>
Other associated genes include TRC8, OGG1, [[HNF1A]], [[HNF1B]], [[TFE3]], RCCP3, and RCC17.
*[[Anemia]]
*[[Polycythemia]]
*[[Hypercalcemia]]
*Elevated[[ESR]]
*Elevated [[liver function tests]]
*Elevated [[alkaline phosphatase]] (ALP)
*Elevated [[lactate dehydrogenase]] (LDH)
*Elevated serum [[creatinine]]
*[[Hematuria]]
*[[Cancer cells]] on urine cytology


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Kidney diseases]]
[[Category:Types of cancer]]
[[Category:Nephrology]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Nephrology]]
[[Category:Surgery]]

Latest revision as of 16:43, 11 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Laboratory findings of renal cell carcinoma include anemia, polycythemia, hypercalcemia, elevated ESR, elevated liver function tests, elevated alkaline phosphatase, elevated lactate dehydrogenase, elevated serum creatinine, hematuria, and cancer cells on urine cytology.

Laboratory Findings

Laboratory findings consistent with the diagnosis of renal cell carcinoma include:[1][2][3][4]

References

  1. O'Grady AS, Morse LJ, Lee JB (November 1965). "Parathyroid hormone-secreting renal carcinoma associated with hypercalcemia and metabolic alkalosis". Ann. Intern. Med. 63 (5): 858–68. PMID 5848632.
  2. Chuang YC, Lin AT, Chen KK, Chang YH, Chen MT, Chang LS (November 1997). "Paraneoplastic elevation of serum alkaline phosphatase in renal cell carcinoma: incidence and implication on prognosis". J. Urol. 158 (5): 1684–7. PMID 9334578.
  3. Sufrin G, Mirand EA, Moore RH, Chu TM, Murphy GP (April 1977). "Hormones in renal cancer". J. Urol. 117 (4): 433–8. PMID 850315.
  4. Nielsen OJ, Jespersen FF, Hilden M (August 1988). "Erythropoietin-induced secondary polycythemia in a patient with a renal cell carcinoma. A case report". APMIS. 96 (8): 688–94. PMID 3046641.