RPS6KA5

Ribosomal protein S6 kinase, 90kDa, polypeptide 5
File:PBB Protein RPS6KA5 image.jpg PDB rendering based on 1vzo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1vzo​
Identifiers
Symbols	RPS6KA5 ; MGC1911; MSK1; MSPK1; RLPK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48302
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RPS6KA5 204635 at tn.png
File:PBB GE RPS6KA5 204633 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ribosomal protein S6 kinase, 90kDa, polypeptide 5, also known as RPS6KA5, is a human gene.

Further reading

• Chung J, Uchida E, Grammer TC, Blenis J (1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation". Mol. Cell. Biol. 17 (11): 6508–16. PMID 9343414.CS1 maint: Multiple names: authors list (link)
• Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMID 9687510.CS1 maint: Multiple names: authors list (link)
• Jain N, Zhang T, Fong SL; et al. (1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157–67. doi:10.1038/sj.onc.1202238. PMID 9872331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• New L, Zhao M, Li Y; et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". J. Biol. Chem. 274 (2): 1026–32. PMID 9873047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thomson S, Clayton AL, Hazzalin CA; et al. (1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase". EMBO J. 18 (17): 4779–93. doi:10.1093/emboj/18.17.4779. PMID 10469656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim CP, Cao X (1999). "Serine phosphorylation and negative regulation of Stat3 by JNK". J. Biol. Chem. 274 (43): 31055–61. PMID 10521505.
• Buck M, Poli V, van der Geer P; et al. (2000). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha". Mol. Cell. 4 (6): 1087–92. PMID 10635333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang C, Yu L, Tu Q; et al. (2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 87 (3–4): 261–2. PMID 10702687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". Biochem. J. 349 (Pt 2): 547–57. PMID 10880354.CS1 maint: Multiple names: authors list (link)
• Hefner Y, Borsch-Haubold AG, Murakami M; et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells". FEBS Lett. 482 (1–2): 44–8. PMID 11018520.
• Sapkota GP, Kieloch A, Lizcano JM; et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deb A, Zamanian-Daryoush M, Xu Z; et al. (2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3". EMBO J. 20 (10): 2487–96. doi:10.1093/emboj/20.10.2487. PMID 11350938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu G, Zhang Y, Bode AM; et al. (2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation". J. Biol. Chem. 277 (11): 8810–6. doi:10.1074/jbc.M110477200. PMID 11777913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiggin GR, Soloaga A, Foster JM; et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–81. PMID 11909979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". Biochem. J. 365 (Pt 3): 757–63. doi:10.1042/BJ20011828. PMID 11994045.
• Toska K, Kleppe R, Armstrong CG; et al. (2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases". J. Neurochem. 83 (4): 775–83. PMID 12421349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367.
• Dolled-Filhart M, Camp RL, Kowalski DP; et al. (2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clin. Cancer Res. 9 (2): 594–600. PMID 12576423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)