RPS6KA4

Ribosomal protein S6 kinase, 90kDa, polypeptide 4
Identifiers
Symbols	RPS6KA4 ; MSK2; RSK-B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69288
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RPS6KA4 204632 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ribosomal protein S6 kinase, 90kDa, polypeptide 4, also known as RPS6KA4, is a human gene.

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–63. PMID 8688081.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMID 9687510.CS1 maint: Multiple names: authors list (link)
• Pierrat B, Correia JS, Mary JL; et al. (1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J. Biol. Chem. 273 (45): 29661–71. PMID 9792677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–9. PMID 9829964.
• Zhu S, Gerhard DS (1999). "A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1". Hum. Genet. 103 (6): 674–80. PMID 9921902.
• Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor". J. Biol. Chem. 275 (31): 23549–58. doi:10.1074/jbc.M002586200. PMID 10806207.CS1 maint: Multiple names: authors list (link)
• Tomás-Zuber M, Mary JL, Lamour F; et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)". J. Biol. Chem. 276 (8): 5892–9. doi:10.1074/jbc.M005822200. PMID 11035004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gudi T, Casteel DE, Vinson C; et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–33. doi:10.1038/sj.onc.1204007. PMID 11175347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prymakowska-Bosak M, Misteli T, Herrera JE; et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMID 11438671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiggin GR, Soloaga A, Foster JM; et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–81. PMID 11909979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soloaga A, Thomson S, Wiggin GR; et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–97. doi:10.1093/emboj/cdg273. PMID 12773393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wissing J, Jänsch L, Nimtz M; et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gesser B, Johansen C, Rasmussen MK; et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect". J. Invest. Dermatol. 127 (9): 2129–37. doi:10.1038/sj.jid.5700859. PMID 17495961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)