RPS6KA3
| Ribosomal protein S6 kinase, 90kDa, polypeptide 3 | |||||||||
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| Identifiers | |||||||||
| Symbols | RPS6KA3 ; RSK; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37940 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE RPS6KA3 203843 at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
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| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is a human gene.[1]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).[1]
References
Further reading
- Omary MB, Baxter GT, Chou CF; et al. (1992). "PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18". J. Cell Biol. 117 (3): 583–93. PMID 1374067.
- Ku NO, Omary MB (1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization". J. Cell Biol. 127 (1): 161–71. PMID 7523419.
- Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Zhao Y, Bjørbaek C, Weremowicz S; et al. (1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation". Mol. Cell. Biol. 15 (8): 4353–63. PMID 7623830.
- Bjørbaek C, Vik TA, Echwald SM; et al. (1995). "Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients". Diabetes. 44 (1): 90–7. PMID 7813820.
- Donnelly AJ, Choo KH, Kozman HM; et al. (1994). "Regional localisation of a non-specific X-linked mental retardation gene (MRX19) to Xp22". Am. J. Med. Genet. 51 (4): 581–5. doi:10.1002/ajmg.1320510457. PMID 7943043.
- Moller DE, Xia CH, Tang W; et al. (1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am. J. Physiol. 266 (2 Pt 1): C351–9. PMID 8141249.
- Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–63. PMID 8688081.
- Trivier E, De Cesare D, Jacquot S; et al. (1997). "Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome". Nature. 384 (6609): 567–70. doi:10.1038/384567a0. PMID 8955270.
- Paudel HK (1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro". J. Biol. Chem. 272 (45): 28328–34. PMID 9353289.
- Joel PB, Smith J, Sturgill TW; et al. (1998). "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167". Mol. Cell. Biol. 18 (4): 1978–84. PMID 9528769.
- Zheng-Fischhöfer Q, Biernat J, Mandelkow EM; et al. (1998). "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation". Eur. J. Biochem. 252 (3): 542–52. PMID 9546672.
- Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMID 9687510.
- Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–9. PMID 9829964.
- Hanger DP, Betts JC, Loviny TL; et al. (1998). "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry". J. Neurochem. 71 (6): 2465–76. PMID 9832145.
- Jacquot S, Merienne K, De Cesare D; et al. (1999). "Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations". Am. J. Hum. Genet. 63 (6): 1631–40. PMID 9837815.
- Jacquot S, Merienne K, Pannetier S; et al. (1999). "Germline mosaicism in Coffin-Lowry syndrome". Eur. J. Hum. Genet. 6 (6): 578–82. doi:10.1038/sj.ejhg.5200230. PMID 9887375.
- Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". J. Biol. Chem. 274 (5): 2893–8. PMID 9915826.
- Abidi F, Jacquot S, Lassiter C; et al. (1999). "Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS)". Eur. J. Hum. Genet. 7 (1): 20–6. doi:10.1038/sj.ejhg.5200231. PMID 10094187.
- Merienne K, Jacquot S, Pannetier S; et al. (1999). "A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation". Nat. Genet. 22 (1): 13–4. doi:10.1038/8719. PMID 10319851.
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